Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM21K0E)

Drug Name

ISOTETRANDRINE Drug Info

Synonyms

O-Methylberbamine; O,O'-Dimethylobamegine; Isosinomenine A; NSC 97338; O,O'-Dimethylstepholine; Isosinomenin A; CHEBI:80898; 1-ISOTETRANDRINE; 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; Hanfangchin A; CCRIS 6540; 6,6& ,7,12-Tetramethoxy-2,2& C38H42N2O6; (+)-Isotetrandrine; tetramethoxy(dimethyl)[ ]; Phaeanthin; O,O-Dimethylobamegine; O,O-Dimethylstepholine; AC1L1KBN; AC1Q58ES; (1.beta.)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; SCHEMBL209832; CHEMBL367260; WVTKBKWTSCPRNU-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 457825
CAS Number: CAS 477-57-6
TTD Drug ID: DM21K0E

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Dopamine transporter (DAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[2]
Dasotraline	DMLDQFV	Attention deficit hyperactivity disorder	6A05.Z	Approved	[3]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[4]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[5]
Phenmetrazine	DMXYTN9	Obesity	5B81	Approved	[6]
Ioflupane i-123	DMNARJT	Parkinson disease	8A00.0	Approved	[7]
DEXMETHYLPHENIDATE HYDROCHLORIDE	DM8WBAH	Attention deficit hyperactivity disorder	6A05.Z	Approved	[8]
Altropane	DMO9WDS	Attention deficit hyperactivity disorder	6A05.Z	Approved	[9]
Amitifadine	DMS1X67	Obesity	5B81	Phase 3	[10]
NAV5001	DMRSI1M	Dementia	6D80-6D86	Phase 3	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]

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References

1	Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.
2	Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009 Jul;93(1):75-81.
3	Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults. Neuropsychopharmacology. 2015 Nov;40(12):2745-52.
4	Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1410-5.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7.
7	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8	Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31.
9	Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41.
10	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927).