Details of the Drug

General Information of Drug (ID: DMYILBE)

Drug Name

Modafinil

Synonyms

Provigil; Modiodal

Indication

Disease Entry	ICD 11	Status	REF
Malignant glioma	2A00.0	Approved	[1]
Methamphetamine dependence	6C46.2	Approved	[1]
Narcolepsy	7A20	Approved	[2]
Pain	MG30-MG3Z	Approved	[1]
Postpoliomyelitis syndrome	N.A.	Approved	[1]
Traumatic brain injury	NA07.Z	Approved	[1]
Bipolar disorder	6A60	Phase 4	[3]
Brain injury	NA07.Z	Investigative	[4]
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⏷ Show the Full List of Indication(s)

Therapeutic Class

Neurology Agents

Affected Organisms

Humans and other mammals

ATC Code

N06BA07: Modafinil

N06BA: Centrally acting sympathomimetics

N06B: PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS

N06: PSYCHOANALEPTICS

N: NERVOUS SYSTEM

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

273.4

Logarithm of the Partition Coefficient (xlogp)

1.7

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption: The drug is rapidly absorbed following oral administration []
BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [5]
Bioavailability: 80% of drug becomes completely available to its intended biological destination(s) [6]
Elimination: 8% of drug is excreted from urine in the unchanged form [5]
Half-life: The concentration or amount of drug in body reduced by one-half in 23 - 215 hours [7]
Metabolism: The drug is metabolized via the hepatic []
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 20.9038 micromolar/kg/day [8]
Vd: The volume of distribution (Vd) of drug is 0.9 L/kg []

Chemical Identifiers

Formula: C15H15NO2S
IUPAC Name: 2-benzhydrylsulfinylacetamide
Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
InChI: InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChIKey: YFGHCGITMMYXAQ-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 4236
ChEBI ID: CHEBI:77585
CAS Number: 68693-11-8
UNII: R3UK8X3U3D
DrugBank ID: DB00745
TTD ID: D07HQC
VARIDT ID: DR00411
INTEDE ID: DR1104
ACDINA ID: D00442

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Modulator	[9]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)_{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[10]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Drug Response	[11]
Sodium-dependent dopamine transporter (SLC6A3)	OT39XG28	SC6A3_HUMAN	Drug Response	[12]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Malignant glioma

ICD Disease Classification

2A00.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	1.76E-01	1.26E-01	8.27E-01

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Modafinil (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Tretinoin	DM49DUI	Minor	Increased metabolism of Modafinil caused by Tretinoin mediated induction of CYP450 enzyme.	Acne vulgaris [ED80]	[13]
Repaglinide	DM5SXUV	Moderate	Increased metabolism of Modafinil caused by Repaglinide mediated induction of CYP450 enzyme.	Acute diabete complication [5A2Y]	[14]
Pioglitazone	DMKJ485	Minor	Increased metabolism of Modafinil caused by Pioglitazone mediated induction of CYP450 enzyme.	Acute diabete complication [5A2Y]	[13]
Ivosidenib	DM8S6T7	Moderate	Increased metabolism of Modafinil caused by Ivosidenib mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[15]
Midostaurin	DMI6E0R	Moderate	Increased metabolism of Modafinil caused by Midostaurin mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[16]
Oliceridine	DM6MDCF	Major	Increased metabolism of Modafinil caused by Oliceridine mediated induction of CYP450 enzyme.	Acute pain [MG31]	[17]
Bepridil	DM0RKS4	Minor	Increased metabolism of Modafinil caused by Bepridil mediated induction of CYP450 enzyme.	Angina pectoris [BA40]	[13]
Dronedarone	DMA8FS5	Moderate	Increased metabolism of Modafinil caused by Dronedarone mediated induction of CYP450 enzyme.	Angina pectoris [BA40]	[18]
Nifedipine	DMSVOZT	Moderate	Increased metabolism of Modafinil caused by Nifedipine mediated induction of CYP450 enzyme.	Angina pectoris [BA40]	[19]
Bedaquiline	DM3906J	Major	Increased metabolism of Modafinil caused by Bedaquiline mediated induction of CYP450 enzyme.	Antimicrobial drug resistance [MG50-MG52]	[20]
Methylphenobarbital	DMDSWAG	Moderate	Increased metabolism of Modafinil caused by Methylphenobarbital mediated induction of CYP450 enzyme.	Anxiety disorder [6B00-6B0Z]	[15]
Halazepam	DMPFWO6	Minor	Increased metabolism of Modafinil caused by Halazepam mediated induction of CYP450 enzyme.	Anxiety disorder [6B00-6B0Z]	[13]
Cilostazol	DMZMSCT	Moderate	Decreased metabolism of Modafinil caused by Cilostazol mediated inhibition of CYP450 enzyme.	Arterial occlusive disease [BD40]	[21]
Posaconazole	DMUL5EW	Minor	Decreased metabolism of Modafinil caused by Posaconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[19]
Desipramine	DMT2FDC	Moderate	Decreased metabolism of Modafinil caused by Desipramine mediated inhibition of CYP450 enzyme.	Attention deficit hyperactivity disorder [6A05]	[19]
Dalfopristin	DM4LTKV	Minor	Decreased metabolism of Modafinil caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Clarithromycin	DM4M1SG	Minor	Decreased metabolism of Modafinil caused by Clarithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Rabeprazole	DMMZXIW	Moderate	Decreased metabolism of Modafinil caused by Rabeprazole mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Troleandomycin	DMUZNIG	Minor	Decreased metabolism of Modafinil caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Telithromycin	DMZ4P3A	Minor	Decreased metabolism of Modafinil caused by Telithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Cariprazine	DMJYDVK	Moderate	Increased metabolism of Modafinil caused by Cariprazine mediated induction of CYP450 enzyme.	Bipolar disorder [6A60]	[22]
Erdafitinib	DMI782S	Major	Increased metabolism of Modafinil caused by Erdafitinib mediated induction of CYP450 enzyme.	Bladder cancer [2C94]	[23]
Pexidartinib	DMS2J0Z	Moderate	Increased metabolism of Modafinil caused by Pexidartinib mediated induction of CYP450 enzyme.	Bone/articular cartilage neoplasm [2F7B]	[24]
Ixabepilone	DM2OZ3G	Minor	Increased metabolism of Modafinil caused by Ixabepilone mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Lapatinib	DM3BH1Y	Moderate	Decreased metabolism of Modafinil caused by Lapatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[25]
HKI-272	DM6QOVN	Major	Increased metabolism of Modafinil caused by HKI-272 mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[19]
LY2835219	DM93VBZ	Moderate	Increased metabolism of Modafinil caused by LY2835219 mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[26]
Exemestane	DM9HPW3	Moderate	Increased metabolism of Modafinil caused by Exemestane mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[27]
Esterified estrogens	DM9KZDO	Minor	Increased metabolism of Modafinil caused by Esterified estrogens mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Tucatinib	DMBESUA	Moderate	Increased metabolism of Modafinil caused by Tucatinib mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[28]
Palbociclib	DMD7L94	Moderate	Increased metabolism of Modafinil caused by Palbociclib mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[19]
Letrozole	DMH07Y3	Minor	Increased metabolism of Modafinil caused by Letrozole mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Quinestrol	DMJ6H1Z	Minor	Increased metabolism of Modafinil caused by Quinestrol mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Cabazitaxel	DMPAZHC	Minor	Increased metabolism of Modafinil caused by Cabazitaxel mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Bosutinib	DMTI8YE	Major	Increased metabolism of Modafinil caused by Bosutinib mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[29]
Estradiol	DMUNTE3	Minor	Increased metabolism of Modafinil caused by Estradiol mediated induction of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[13]
Atorvastatin	DMF28YC	Minor	Increased metabolism of Modafinil caused by Atorvastatin mediated induction of CYP450 enzyme.	Cardiovascular disease [BA00-BE2Z]	[13]
Macitentan	DMP79A1	Minor	Increased metabolism of Modafinil caused by Macitentan mediated induction of CYP450 enzyme.	Cardiovascular disease [BA00-BE2Z]	[13]
PF-04449913	DMSB068	Major	Increased metabolism of Modafinil caused by PF-04449913 mediated induction of CYP450 enzyme.	Chronic myelomonocytic leukaemia [2A40]	[30]
Phenylbutazone	DMAYL0T	Moderate	Increased metabolism of Modafinil caused by Phenylbutazone mediated induction of CYP450 enzyme.	Chronic pain [MG30]	[15]
Dihydrocodeine	DMB0FWL	Minor	Increased metabolism of Modafinil caused by Dihydrocodeine mediated induction of CYP450 enzyme.	Chronic pain [MG30]	[13]
Anisindione	DM2C48U	Moderate	Decreased metabolism of Modafinil caused by Anisindione mediated inhibition of CYP450 enzyme.	Coagulation defect [3B10]	[19]
Irinotecan	DMP6SC2	Moderate	Increased metabolism of Modafinil caused by Irinotecan mediated induction of CYP450 enzyme.	Colorectal cancer [2B91]	[31]
Drospirenone	DM1A9W3	Moderate	Increased metabolism of Modafinil caused by Drospirenone mediated induction of CYP450 enzyme.	Contraceptive management [QA21]	[19]
Levonorgestrel	DM1DP7T	Moderate	Increased metabolism of Modafinil caused by Levonorgestrel mediated induction of CYP450 enzyme.	Contraceptive management [QA21]	[19]
Ulipristal	DMBNI20	Moderate	Increased metabolism of Modafinil caused by Ulipristal mediated induction of CYP450 enzyme.	Contraceptive management [QA21]	[20]
Norgestimate	DMYP4XC	Moderate	Increased metabolism of Modafinil caused by Norgestimate mediated induction of CYP450 enzyme.	Contraceptive management [QA21]	[32]
Levobupivacaine	DM783CH	Minor	Increased metabolism of Modafinil caused by Levobupivacaine mediated induction of CYP450 enzyme.	Corneal disease [9A76-9A78]	[33]
Halothane	DM80OZ5	Minor	Increased metabolism of Modafinil caused by Halothane mediated induction of CYP450 enzyme.	Corneal disease [9A76-9A78]	[13]
Alfentanil	DMVO0UB	Minor	Increased metabolism of Modafinil caused by Alfentanil mediated induction of CYP450 enzyme.	Corneal disease [9A76-9A78]	[13]
Mifepristone	DMGZQEF	Minor	Decreased metabolism of Modafinil caused by Mifepristone mediated inhibition of CYP450 enzyme.	Cushing syndrome [5A70]	[19]
Osilodrostat	DMIJC9X	Moderate	Increased metabolism of Modafinil caused by Osilodrostat mediated induction of CYP450 enzyme.	Cushing syndrome [5A70]	[34]
Ivacaftor	DMZC1HS	Minor	Decreased metabolism of Modafinil caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[19]
Rivaroxaban	DMQMBZ1	Minor	Increased metabolism of Modafinil caused by Rivaroxaban mediated induction of CYP450 enzyme.	Deep vein thrombosis [BD71]	[13]
Cyclobenzaprine	DM1YBRM	Minor	Increased metabolism of Modafinil caused by Cyclobenzaprine mediated induction of CYP450 enzyme.	Depression [6A70-6A7Z]	[13]
Vilazodone	DM4LECQ	Minor	Increased metabolism of Modafinil caused by Vilazodone mediated induction of CYP450 enzyme.	Depression [6A70-6A7Z]	[13]
Nefazodone	DM4ZS8M	Minor	Decreased metabolism of Modafinil caused by Nefazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[19]
Escitalopram	DMFK9HG	Moderate	Decreased metabolism of Modafinil caused by Escitalopram mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[17]
OPC-34712	DMHG57U	Minor	Increased metabolism of Modafinil caused by OPC-34712 mediated induction of CYP450 enzyme.	Depression [6A70-6A7Z]	[13]
Clomipramine	DMINRKW	Moderate	Decreased metabolism of Modafinil caused by Clomipramine mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[19]
Doxepin	DMPI98T	Moderate	Decreased metabolism of Modafinil caused by Doxepin mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[19]
Esketamine	DMVU687	Major	Additive hypertensive effects by the combination of Modafinil and Esketamine.	Depression [6A70-6A7Z]	[19]
[3H]estrone-3-sulphate	DMGPF0N	Minor	Increased metabolism of Modafinil caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme.	Discovery agent [N.A.]	[13]
Oxybutynine	DMJPBAX	Minor	Increased metabolism of Modafinil caused by Oxybutynine mediated induction of CYP450 enzyme.	Discovery agent [N.A.]	[13]
Oestradiol valerate and dienogest	DMZK0FQ	Moderate	Increased metabolism of Modafinil caused by Oestradiol valerate and dienogest mediated induction of CYP450 enzyme.	Endometriosis [GA10]	[32]
Diazepam	DM08E9O	Moderate	Decreased metabolism of Modafinil caused by Diazepam mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[19]
Zonisamide	DM0DTF7	Minor	Increased metabolism of Modafinil caused by Zonisamide mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[13]
Primidone	DM0WX6I	Moderate	Increased metabolism of Modafinil caused by Primidone mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Felbamate	DM1V5ZS	Moderate	Increased metabolism of Modafinil caused by Felbamate mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Oxcarbazepine	DM5PU6O	Moderate	Increased metabolism of Modafinil caused by Oxcarbazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Cenobamate	DM8KLU9	Moderate	Increased metabolism of Modafinil caused by Cenobamate mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Tiagabine	DMKSQG0	Minor	Increased metabolism of Modafinil caused by Tiagabine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[13]
Stiripentol	DMMSDOY	Moderate	Increased metabolism of Modafinil caused by Stiripentol mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[20]
Fosphenytoin	DMOX3LB	Moderate	Decreased metabolism of Modafinil caused by Fosphenytoin mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[19]
Brivaracetam	DMSEPK8	Minor	Decreased metabolism of Modafinil caused by Brivaracetam mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[20]
Clonazepam	DMTO13J	Minor	Increased metabolism of Modafinil caused by Clonazepam mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[13]
Rufinamide	DMWE60C	Moderate	Increased metabolism of Modafinil caused by Rufinamide mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Phenobarbital	DMXZOCG	Moderate	Increased metabolism of Modafinil caused by Phenobarbital mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Eslicarbazepine	DMZREFQ	Moderate	Increased metabolism of Modafinil caused by Eslicarbazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Praziquantel	DMOU1PK	Moderate	Increased metabolism of Modafinil caused by Praziquantel mediated induction of CYP450 enzyme.	Flatworm infection [1F70-1F86]	[35]
Bay 80-6946	DMLOS5R	Moderate	Increased metabolism of Modafinil caused by Bay 80-6946 mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[36]
Tazemetostat	DMWP1BH	Major	Increased metabolism of Modafinil caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[37]
Solifenacin	DMG592Q	Minor	Increased metabolism of Modafinil caused by Solifenacin mediated induction of CYP450 enzyme.	Functional bladder disorder [GC50]	[13]
Mirabegron	DMS1GYT	Minor	Increased metabolism of Modafinil caused by Mirabegron mediated induction of CYP450 enzyme.	Functional bladder disorder [GC50]	[38]
Tolterodine	DMSHPW8	Minor	Increased metabolism of Modafinil caused by Tolterodine mediated induction of CYP450 enzyme.	Functional bladder disorder [GC50]	[13]
Itraconazole	DMCR1MV	Minor	Decreased metabolism of Modafinil caused by Itraconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Miconazole	DMPMYE8	Minor	Decreased metabolism of Modafinil caused by Miconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Ketoconazole	DMPZI3Q	Minor	Decreased metabolism of Modafinil caused by Ketoconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Ripretinib	DM958QB	Moderate	Increased metabolism of Modafinil caused by Ripretinib mediated induction of CYP450 enzyme.	Gastrointestinal stromal tumour [2B5B]	[19]
Sunitinib	DMCBJSR	Moderate	Increased metabolism of Modafinil caused by Sunitinib mediated induction of CYP450 enzyme.	Gastrointestinal stromal tumour [2B5B]	[19]
Avapritinib	DMK2GZX	Major	Increased metabolism of Modafinil caused by Avapritinib mediated induction of CYP450 enzyme.	Gastrointestinal stromal tumour [2B5B]	[20]
Colchicine	DM2POTE	Minor	Increased metabolism of Modafinil caused by Colchicine mediated induction of CYP450 enzyme.	Gout [FA25]	[13]
Sulfinpyrazone	DMEV954	Moderate	Increased metabolism of Modafinil caused by Sulfinpyrazone mediated induction of CYP450 enzyme.	Gout [FA25]	[15]
Boceprevir	DMBSHMF	Minor	Decreased metabolism of Modafinil caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[19]
PSI-7977	DMLSUWZ	Major	Accelerated clearance of Modafinil due to the transporter induction by PSI-7977.	Hepatitis virus infection [1E50-1E51]	[19]
Telaprevir	DMMRV29	Minor	Decreased metabolism of Modafinil caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[19]
Daclatasvir	DMSFK9V	Major	Increased metabolism of Modafinil caused by Daclatasvir mediated induction of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[20]
Isoniazid	DM5JVS3	Minor	Decreased metabolism of Modafinil caused by Isoniazid mediated inhibition of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[19]
Rifampin	DMA8J1G	Moderate	Increased metabolism of Modafinil caused by Rifampin mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[15]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Modafinil caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[15]
Pretomanid	DMDYA31	Major	Increased metabolism of Modafinil caused by Pretomanid mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[39]
MK-1439	DM215WE	Major	Increased metabolism of Modafinil caused by MK-1439 mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[20]
Fosamprenavir	DM4W9B3	Moderate	Increased metabolism of Modafinil caused by Fosamprenavir mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[40]
Fostemsavir	DM50ILT	Minor	Increased metabolism of Modafinil caused by Fostemsavir mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[41]
Cobicistat	DM6L4H2	Moderate	Increased metabolism of Modafinil caused by Cobicistat mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[17]
Dolutegravir	DMCZGRE	Minor	Increased metabolism of Modafinil caused by Dolutegravir mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[13]
Saquinavir	DMG814N	Moderate	Increased metabolism of Modafinil caused by Saquinavir mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[40]
Elvitegravir	DMG9B1U	Moderate	Increased metabolism of Modafinil caused by Elvitegravir mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Etravirine	DMGV8QU	Moderate	Increased metabolism of Modafinil caused by Etravirine mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[42]
Lopinavir	DMITQS0	Moderate	Decreased metabolism of Modafinil caused by Lopinavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Rilpivirine	DMJ0QOW	Moderate	Increased metabolism of Modafinil caused by Rilpivirine mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Darunavir	DMN3GCH	Minor	Decreased metabolism of Modafinil caused by Darunavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Atazanavir	DMSYRBX	Moderate	Increased metabolism of Modafinil caused by Atazanavir mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[40]
Maraviroc	DMTL94F	Moderate	Increased metabolism of Modafinil caused by Maraviroc mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
BMS-201038	DMQTAGO	Moderate	Decreased clearance of Modafinil due to the transporter inhibition by BMS-201038.	Hyper-lipoproteinaemia [5C80]	[43]
Levamlodipine	DM92S6N	Minor	Increased metabolism of Modafinil caused by Levamlodipine mediated induction of CYP450 enzyme.	Hypertension [BA00-BA04]	[13]
Felodipine	DMOSW35	Moderate	Increased metabolism of Modafinil caused by Felodipine mediated induction of CYP450 enzyme.	Hypertension [BA00-BA04]	[19]
Conivaptan	DM1V329	Minor	Decreased metabolism of Modafinil caused by Conivaptan mediated inhibition of CYP450 enzyme.	Hypo-osmolality/hyponatraemia [5C72]	[19]
Tolvaptan	DMIWFRL	Moderate	Increased metabolism of Modafinil caused by Tolvaptan mediated induction of CYP450 enzyme.	Hypo-osmolality/hyponatraemia [5C72]	[20]
Berotralstat	DMWA2DZ	Minor	Decreased metabolism of Modafinil caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[19]
Suvorexant	DM0E6S3	Minor	Decreased metabolism of Modafinil caused by Suvorexant mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[19]
Amobarbital	DM0GQ8N	Moderate	Increased metabolism of Modafinil caused by Amobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[15]
Ramelteon	DM7IW9J	Moderate	Increased metabolism of Modafinil caused by Ramelteon mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[44]
Triazolam	DMETYK5	Moderate	Increased metabolism of Modafinil caused by Triazolam mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[15]
Tasimelteon	DMLOQ1V	Moderate	Increased metabolism of Modafinil caused by Tasimelteon mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[45]
ITI-007	DMUQ1DO	Major	Increased metabolism of Modafinil caused by ITI-007 mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[46]
Quazepam	DMY4D87	Minor	Increased metabolism of Modafinil caused by Quazepam mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[13]
Estazolam	DMZGXUM	Minor	Increased metabolism of Modafinil caused by Estazolam mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[13]
Naloxegol	DML0B41	Minor	Increased metabolism of Modafinil caused by Naloxegol mediated induction of CYP450 enzyme.	Large intestine motility disorder [DB32]	[13]
Pemigatinib	DM819JF	Major	Increased metabolism of Modafinil caused by Pemigatinib mediated induction of CYP450 enzyme.	Liver cancer [2C12]	[20]
Crizotinib	DM4F29C	Minor	Decreased metabolism of Modafinil caused by Crizotinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[19]
Ceritinib	DMB920Z	Moderate	Increased metabolism of Modafinil caused by Ceritinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[47]
Lurbinectedin	DMEFRTZ	Major	Decreased metabolism of Modafinil caused by Lurbinectedin mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[48]
PF-06463922	DMKM7EW	Major	Increased metabolism of Modafinil caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[49]
Osimertinib	DMRJLAT	Moderate	Increased metabolism of Modafinil caused by Osimertinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[50]
Pralsetinib	DMWU0I2	Moderate	Increased metabolism of Modafinil caused by Pralsetinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[51]
Capmatinib	DMYCXKL	Major	Increased metabolism of Modafinil caused by Capmatinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[52]
Selpercatinib	DMZR15V	Moderate	Increased metabolism of Modafinil caused by Selpercatinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[20]
Artemether	DM48QOT	Moderate	Increased metabolism of Modafinil caused by Artemether mediated induction of CYP450 enzyme.	Malaria [1F40-1F45]	[19]
Proguanil	DMBL79I	Moderate	Decreased metabolism of Modafinil caused by Proguanil mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[19]
Halofantrine	DMOMK1V	Minor	Increased metabolism of Modafinil caused by Halofantrine mediated induction of CYP450 enzyme.	Malaria [1F40-1F45]	[13]
Idelalisib	DM602WT	Minor	Decreased metabolism of Modafinil caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[19]
GDC-0199	DMH0QKA	Major	Increased metabolism of Modafinil caused by GDC-0199 mediated induction of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[53]
IPI-145	DMWA24P	Moderate	Increased metabolism of Modafinil caused by IPI-145 mediated induction of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[54]
Acalabrutinib	DM7GCVW	Moderate	Increased metabolism of Modafinil caused by Acalabrutinib mediated induction of CYP450 enzyme.	Mature B-cell lymphoma [2A85]	[55]
Ibrutinib	DMHZCPO	Minor	Increased metabolism of Modafinil caused by Ibrutinib mediated induction of CYP450 enzyme.	Mature B-cell lymphoma [2A85]	[13]
Ponatinib	DMYGJQO	Minor	Increased metabolism of Modafinil caused by Ponatinib mediated induction of CYP450 enzyme.	Mature B-cell lymphoma [2A85]	[13]
Arry-162	DM1P6FR	Moderate	Increased metabolism of Modafinil caused by Arry-162 mediated induction of CYP450 enzyme.	Melanoma [2C30]	[19]
Vemurafenib	DM62UG5	Moderate	Increased metabolism of Modafinil caused by Vemurafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[56]
Selumetinib	DMC7W6R	Major	Increased metabolism of Modafinil caused by Selumetinib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[57]
LGX818	DMNQXV8	Major	Increased metabolism of Modafinil caused by LGX818 mediated induction of CYP450 enzyme.	Melanoma [2C30]	[58]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Modafinil caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[20]
Ethinyl estradiol	DMODJ40	Moderate	Increased metabolism of Modafinil caused by Ethinyl estradiol mediated induction of CYP450 enzyme.	Menopausal disorder [GA30]	[32]
Danazol	DML8KTN	Minor	Decreased metabolism of Modafinil caused by Danazol mediated inhibition of CYP450 enzyme.	Menstrual cycle bleeding disorder [GA20]	[19]
Ubrogepant	DM749I3	Moderate	Increased metabolism of Modafinil caused by Ubrogepant mediated induction of CYP450 enzyme.	Migraine [8A80]	[59]
Almogran	DM7I64Z	Minor	Increased metabolism of Modafinil caused by Almogran mediated induction of CYP450 enzyme.	Migraine [8A80]	[13]
Rimegepant	DMHOAUG	Major	Increased metabolism of Modafinil caused by Rimegepant mediated induction of CYP450 enzyme.	Migraine [8A80]	[60]
Exjade	DMHPRWG	Moderate	Increased metabolism of Modafinil caused by Exjade mediated induction of CYP450 enzyme.	Mineral absorption/transport disorder [5C64]	[15]
Flibanserin	DM70DTN	Moderate	Increased metabolism of Modafinil caused by Flibanserin mediated induction of CYP450 enzyme.	Mood disorder [6A60-6E23]	[61]
Panobinostat	DM58WKG	Moderate	Increased metabolism of Modafinil caused by Panobinostat mediated induction of CYP450 enzyme.	Multiple myeloma [2A83]	[62]
Siponimod	DM2R86O	Major	Increased metabolism of Modafinil caused by Siponimod mediated induction of CYP450 enzyme.	Multiple sclerosis [8A40]	[19]
Deflazacort	DMV0RNS	Major	Increased metabolism of Modafinil caused by Deflazacort mediated induction of CYP450 enzyme.	Muscular dystrophy [8C70]	[20]
Fedratinib	DM4ZBK6	Major	Increased metabolism of Modafinil caused by Fedratinib mediated induction of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[20]
Nilotinib	DM7HXWT	Minor	Decreased metabolism of Modafinil caused by Nilotinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[19]
Ruxolitinib	DM7Q98D	Minor	Increased metabolism of Modafinil caused by Ruxolitinib mediated induction of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[13]
Busulfan	DMXYJ9C	Minor	Increased metabolism of Modafinil caused by Busulfan mediated induction of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[13]
Rolapitant	DM8XP26	Moderate	Increased metabolism of Modafinil caused by Rolapitant mediated induction of CYP450 enzyme.	Nausea/vomiting [MD90]	[20]
Netupitant	DMEKAYI	Minor	Decreased metabolism of Modafinil caused by Netupitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[19]
Granisetron	DMIUW25	Minor	Increased metabolism of Modafinil caused by Granisetron mediated induction of CYP450 enzyme.	Nausea/vomiting [MD90]	[13]
Ondansetron	DMOTQ1I	Minor	Increased metabolism of Modafinil caused by Ondansetron mediated induction of CYP450 enzyme.	Nausea/vomiting [MD90]	[13]
Entrectinib	DMMPTLH	Major	Increased metabolism of Modafinil caused by Entrectinib mediated induction of CYP450 enzyme.	Non-small cell lung cancer [2C25]	[63]
Levomethadyl Acetate	DM06HG5	Major	Increased metabolism of Modafinil caused by Levomethadyl Acetate mediated induction of CYP450 enzyme.	Opioid use disorder [6C43]	[64]
S-297995	DM26IH8	Minor	Increased metabolism of Modafinil caused by S-297995 mediated induction of CYP450 enzyme.	Opioid use disorder [6C43]	[13]
Olaparib	DM8QB1D	Major	Increased metabolism of Modafinil caused by Olaparib mediated induction of CYP450 enzyme.	Ovarian cancer [2C73]	[19]
Rucaparib	DM9PVX8	Minor	Decreased metabolism of Modafinil caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[19]
Buprenorphine	DMPRI8G	Minor	Increased metabolism of Modafinil caused by Buprenorphine mediated induction of CYP450 enzyme.	Pain [MG30-MG3Z]	[13]
Hydrocodone	DMQ2JO5	Major	Increased metabolism of Modafinil caused by Hydrocodone mediated induction of CYP450 enzyme.	Pain [MG30-MG3Z]	[17]
Istradefylline	DM20VSK	Minor	Increased metabolism of Modafinil caused by Istradefylline mediated induction of CYP450 enzyme.	Parkinsonism [8A00]	[13]
Pimavanserin	DMR7IVC	Moderate	Increased metabolism of Modafinil caused by Pimavanserin mediated induction of CYP450 enzyme.	Parkinsonism [8A00]	[65]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Modafinil caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[66]
Macimorelin	DMQYJIR	Moderate	Increased metabolism of Modafinil caused by Macimorelin mediated induction of CYP450 enzyme.	Pituitary gland disorder [5A60-5A61]	[67]
Lefamulin	DME6G97	Major	Increased metabolism of Modafinil caused by Lefamulin mediated induction of CYP450 enzyme.	Pneumonia [CA40]	[68]
Ergonovine	DM0VEC1	Moderate	Increased metabolism of Modafinil caused by Ergonovine mediated induction of CYP450 enzyme.	Postpartum haemorrhage [JA43]	[19]
Lonafarnib	DMGM2Z6	Major	Increased metabolism of Modafinil caused by Lonafarnib mediated induction of CYP450 enzyme.	Premature ageing appearance [LD2B]	[69]
Enzalutamide	DMGL19D	Moderate	Increased metabolism of Modafinil caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[70]
Darolutamide	DMV7YFT	Moderate	Increased metabolism of Modafinil caused by Darolutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[71]
Silodosin	DMJSBT6	Moderate	Increased metabolism of Modafinil caused by Silodosin mediated induction of CYP450 enzyme.	Prostate hyperplasia [GA90]	[19]
Dutasteride	DMQ4TJK	Minor	Increased metabolism of Modafinil caused by Dutasteride mediated induction of CYP450 enzyme.	Prostate hyperplasia [GA90]	[13]
Apremilast	DMTWS9E	Minor	Increased metabolism of Modafinil caused by Apremilast mediated induction of CYP450 enzyme.	Psoriasis [EA90]	[13]
Ambrisentan	DMD1QXW	Minor	Increased metabolism of Modafinil caused by Ambrisentan mediated induction of CYP450 enzyme.	Pulmonary hypertension [BB01]	[13]
Riociguat	DMXBLMP	Minor	Increased metabolism of Modafinil caused by Riociguat mediated induction of CYP450 enzyme.	Pulmonary hypertension [BB01]	[13]
Everolimus	DM8X2EH	Moderate	Increased metabolism of Modafinil caused by Everolimus mediated induction of CYP450 enzyme.	Renal cell carcinoma [2C90]	[19]
Axitinib	DMGVH6N	Major	Increased metabolism of Modafinil caused by Axitinib mediated induction of CYP450 enzyme.	Renal cell carcinoma [2C90]	[72]
Temsirolimus	DMS104F	Minor	Increased metabolism of Modafinil caused by Temsirolimus mediated induction of CYP450 enzyme.	Renal cell carcinoma [2C90]	[13]
Upadacitinib	DM32B5U	Moderate	Increased metabolism of Modafinil caused by Upadacitinib mediated induction of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[73]
Tofacitinib	DMBS370	Minor	Increased metabolism of Modafinil caused by Tofacitinib mediated induction of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[13]
Dexamethasone	DMMWZET	Moderate	Increased metabolism of Modafinil caused by Dexamethasone mediated induction of CYP450 enzyme.	Rheumatoid arthritis [FA20]	[15]
Quetiapine	DM1N62C	Minor	Increased metabolism of Modafinil caused by Quetiapine mediated induction of CYP450 enzyme.	Schizophrenia [6A20]	[13]
Aripiprazole	DM3NUMH	Minor	Increased metabolism of Modafinil caused by Aripiprazole mediated induction of CYP450 enzyme.	Schizophrenia [6A20]	[13]
Pimozide	DMW83TP	Minor	Increased metabolism of Modafinil caused by Pimozide mediated induction of CYP450 enzyme.	Schizophrenia [6A20]	[13]
Fentanyl	DM8WAHT	Major	Increased metabolism of Modafinil caused by Fentanyl mediated induction of CYP450 enzyme.	Sensation disturbance [MB40]	[17]
Avanafil	DM75CXN	Minor	Increased metabolism of Modafinil caused by Avanafil mediated induction of CYP450 enzyme.	Sexual dysfunction [HA00-HA01]	[13]
Tadalafil	DMJZHT1	Minor	Increased metabolism of Modafinil caused by Tadalafil mediated induction of CYP450 enzyme.	Sexual dysfunction [HA00-HA01]	[13]
Vardenafil	DMTBGW8	Minor	Increased metabolism of Modafinil caused by Vardenafil mediated induction of CYP450 enzyme.	Sexual dysfunction [HA00-HA01]	[13]
Voxelotor	DMCS6M5	Major	Increased metabolism of Modafinil caused by Voxelotor mediated induction of CYP450 enzyme.	Sickle-cell disorder [3A51]	[74]
LDE225	DMM9F25	Major	Increased metabolism of Modafinil caused by LDE225 mediated induction of CYP450 enzyme.	Skin cancer [2C30-2C37]	[75]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Modafinil caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[20]
Larotrectinib	DM26CQR	Moderate	Increased metabolism of Modafinil caused by Larotrectinib mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[19]
Methylprednisolone	DM4BDON	Minor	Increased metabolism of Modafinil caused by Methylprednisolone mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Ifosfamide	DMCT3I8	Minor	Increased metabolism of Modafinil caused by Ifosfamide mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[76]
Docetaxel	DMDI269	Minor	Increased metabolism of Modafinil caused by Docetaxel mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Trabectedin	DMG3Y89	Moderate	Increased metabolism of Modafinil caused by Trabectedin mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[20]
LEE011	DMMX75K	Moderate	Increased metabolism of Modafinil caused by LEE011 mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[19]
Etoposide	DMNH3PG	Minor	Increased metabolism of Modafinil caused by Etoposide mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Prednisolone	DMQ8FR2	Minor	Increased metabolism of Modafinil caused by Prednisolone mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Taxol	DMUOT9V	Minor	Increased metabolism of Modafinil caused by Taxol mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Doxorubicin	DMVP5YE	Minor	Increased metabolism of Modafinil caused by Doxorubicin mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[13]
Fostamatinib	DM6AUHV	Moderate	Increased metabolism of Modafinil caused by Fostamatinib mediated induction of CYP450 enzyme.	Thrombocytopenia [3B64]	[77]
Apixaban	DM89JLN	Minor	Increased metabolism of Modafinil caused by Apixaban mediated induction of CYP450 enzyme.	Thrombosis [DB61-GB90]	[13]
Brilinta	DMBR01X	Moderate	Increased metabolism of Modafinil caused by Brilinta mediated induction of CYP450 enzyme.	Thrombosis [DB61-GB90]	[17]
Clopidogrel	DMOL54H	Moderate	Decreased metabolism of Modafinil caused by Clopidogrel mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[78]
Sirolimus	DMGW1ID	Moderate	Increased metabolism of Modafinil caused by Sirolimus mediated induction of CYP450 enzyme.	Transplant rejection [NE84]	[19]
Tacrolimus	DMZ7XNQ	Moderate	Increased metabolism of Modafinil caused by Tacrolimus mediated induction of CYP450 enzyme.	Transplant rejection [NE84]	[19]
Saxagliptin	DMGXENV	Minor	Increased metabolism of Modafinil caused by Saxagliptin mediated induction of CYP450 enzyme.	Type 2 diabetes mellitus [5A11]	[13]
Linagliptin	DMWFJTR	Moderate	Increased metabolism of Modafinil caused by Linagliptin mediated induction of CYP450 enzyme.	Type 2 diabetes mellitus [5A11]	[79]
Elagolix	DMB2C0E	Moderate	Increased metabolism of Modafinil caused by Elagolix mediated induction of CYP450 enzyme.	Uterine fibroid [2E86]	[80]
Betrixaban	DM2C4RF	Moderate	Accelerated clearance of Modafinil due to the transporter induction by Betrixaban.	Venous thromboembolism [BD72]	[81]
-----------


⏷ Show the Full List of 227 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sodium stearyl fumarate	E00545	23665634	lubricant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Calcium hydrogenphosphate	E00294	24441	Diluent
Carmellose sodium	E00625	Not Available	Disintegrant
Crospovidone	E00626	Not Available	Disintegrant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
--------------------


⏷ Show the Full List of 13 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Modafinil 100 mg tablet	100 mg	Oral Tablet	Oral
Modafinil 200 mg tablet	200 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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67	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
68	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
69	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
70	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
71	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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74	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
75	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
76	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
77	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
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80	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
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