Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM264B3)

Drug Name

Dimenhydrinate Drug Info

Synonyms

Gravamin (TN); Gravol (TN); Vertirosan (TN); Dimenhydrinate (JP15/USP/INN); 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide; 2-benzhydryloxyethyl(dimethyl)azanium; 8-chloro-1,3-dimethyl-2-oxopurin-6-olate; 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)

Indication

Disease Entry	ICD 11	Status	REF
Meniere disease	AB31.0	Approved	[1]
Nausea	MD90	Approved	[2]
Vomiting	MD90	Approved	[1]

Therapeutic Class

Antiemetics

Cross-matching ID

PubChem CID: 10660
ChEBI ID: CHEMBL1200406
CAS Number: CAS 523-87-5
TTD Drug ID: DM264B3
ACDINA Drug ID: D00201

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Histamine H1 receptor (H1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[4]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[5]
Azelastine	DMXTMBJ	Allergic conjunctivitis	9A60.02	Approved	[6]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Cinnarizine	DM7U5QJ	Meniere disease	AB31.0	Approved	[8]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[6]
Doxepin	DMPI98T	Anxiety		Approved	[9]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[6]
Epinastine	DMX0K3Q	Allergic conjunctivitis	9A60.02	Approved	[10]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[3]

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References

1	Dimenhydrinate FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040519.
3	Histamine 1 receptor antagonist in symptomatic treatment of renal colic accompanied by nausea: two birds with one stone Urology. 2009 Jan;73(1):32-6.
4	Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.
5	Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;23(2):63-6.
6	Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79.
7	Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
8	Central effects of cinnarizine: restricted use in aircrew. Aviat Space Environ Med. 2002 Jun;73(6):570-4.
9	Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305.
10	Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cell... Mediators Inflamm. 2009;2009:738038.
11	Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England. Drug Saf. 2009;32(2):169-79.