Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2HU9I)

Drug Name
Triamterene Drug Info
Synonyms
Ademin; Ademine; Amteren; Anjal; Dazid; Diarol; Dinazide; Diren; Ditak; Diucelpin; Diurene; Diutensat; Diuteren; Dyberzide; Dyren; Dyrenium; Dytac; Dytenzide; Esiteren; Hidiurese; Hydrene; Hypertorr; Isobar; Jatropur; Jenateren; Kalspare; Masuharmin; Nephral; Noridil; Noridyl; Pterofen; Pterophene; Renezide; Reviten; Taturil; Teriam; Teridin; Triamizide; Triampur; Triamteren; Triamterena; Triamterenum; Triamteril; Triamterine; Triamthiazid; Tricilone; Trispan; Triteren; Triurene; Trizid; Turfa; Uretren; Urocaudal; Goldshield Brand of Triamterene; Jorba Brand of Triamterene; Pter ophene; SmithKline Beecham Brand of Triamterene; TRIAMTERENE USP; Thiazid Wolff; Triamteril complex; Wellspring Brand of Triamterene; Fluss 40; SKF 8542; T 4143; Ademin(e); Apo-triazide; Dyrenium (TN); Pteridine deriv. 11; SALI-PUREN; SK&F 8542; SK-8542; Tri-Span; Triamterena [INN-Spanish]; Triamterenum [INN-Latin]; SK&F-8542; Triamterene (JP15/USP/INN); Triamterene [USAN:INN:BAN:JAN]; 2,4,7-Triamino-6-fenilpteridina; 2,4,7-Triamino-6-fenilpteridina [Italian]; 2,4,7-Triamino-6-phenylpteridine; 6-PHENYL-2,4,7-TRIAMINO PTERIDINE; 6-Phenyl-2,4,7-pteridinetriamine; 6-Phenyl-2,4,7-triaminopteridine; 6-phenylpteridine-2,4,7-triamine
Indication
Disease Entry ICD 11 Status REF
Congestive heart failure BD10 Approved [1]
Edema MG29 Approved [1]
Hypertension BA00-BA04 Approved [1]
High blood pressure BA00 Investigative [2]
Therapeutic Class
Diuretics
Cross-matching ID
PubChem CID
5546
ChEBI ID
CHEBI:9671
CAS Number
CAS 396-01-0
TTD Drug ID
DM2HU9I
VARIDT Drug ID
DR01341
INTEDE Drug ID
DR1636
ACDINA Drug ID
D00700

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Amiloride-sensitive sodium channel (ENaC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VX-371 DMSTHG1 Cystic fibrosis CA25 Phase 2 [9]
benzamil DM57SVW Discovery agent N.A. Investigative [10]
S3969 DM84DMW Discovery agent N.A. Investigative [11]
Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [12]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [14]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [15]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [17]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [18]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [19]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [20]
Propranolol DM79NTF Angina pectoris BA40 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [22]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [28]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [29]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [31]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [32]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [32]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [32]
Capsaicin DMGMF6V Back pain ME84.Z Approved [33]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [34]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [35]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [36]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [39]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Prednisone DM2HG4X Acute asthma CA23 Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Epinephrine DM3KJBC Acute asthma CA23 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Fluoxetine DM3PD2C Bipolar depression Approved [46]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [53]
Paclitaxel DMLB81S Breast carcinoma Approved [54]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [61]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [62]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [68]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Amiloride-sensitive sodium channel (ENaC) TTQM7TE SCNNA_HUMAN; SCNNB_HUMAN; SCNNG_HUMAN; SCNND_HUMAN Blocker [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Biotransformations [5]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [7]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Gene/Protein Processing [8]

References

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2 Triamterene FDA Label
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