Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3816P)

• Drug Name: PAC-14028 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 56649347
  CAS Number: CAS 1005168-10-4
  TTD Drug ID: DM3816P

Molecule-Related Drug Atlas

Drug(s) Targeting Transient receptor potential cation channel V1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[3]
CNTX-4975	DMB4JPG	Knee osteoarthritis	FA01	Phase 3	[4]
XEN-D0501	DMG7PDY	Overactive bladder	GC50.0	Phase 2	[5]
Resiniferatoxin	DMP62L5	Neuropathic pain	8E43.0	Phase 2	[6]
GRC-15300	DMWXJSZ	Pain	MG30-MG3Z	Phase 2	[7]
DWP-05195	DMQKU2F	Neuropathic pain	8E43.0	Phase 2	[8]
SB-705498	DMRYHWI	Rhinitis	FA20	Phase 2	[9]
GRC-6211	DMZ0D3V	Asthma	CA23	Phase 1	[10]
ABT-102	DMJFWPR	Chronic pain	MG30	Phase 1	[9]
MR-1817	DMVNLGW	Pain	MG30-MG3Z	Phase 1	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V1 (TRPV1)	TTMI6F5	TRPV1_HUMAN	Antagonist	[2]

References

• [1] ClinicalTrials.gov (NCT02052531) Efficacy and Safety Study of PAC-14028 Cream in Dermal Pruritus. U.S. National Institutes of Health.
• [2] Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6.
• [3] Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol. 2011 Dec;72(6):921-31.
• [6] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [7] The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest. 2010 November 1; 120(11): 3753-3759.
• [8] TRPV1 Antagonists as Analgesic Agents. The Open Pain Journal, 2013, 6, (Suppl 1: M11), 108-118 .
• [9] Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6.
• [10] GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol. 2009 Jan;181(1):379-86.
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030745)