Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3RBJW)

Drug Name

MB-11055 Drug Info

Synonyms

Cryptotanshinone, MD BioAlpha; Cryptotanshinone, Mazence; AMP activated protein kinase stimulator (liver cirrhosis/steatosis/steatohepatitis), Mazence; AMPK stimulator (liver cirrhosis/steatosis/steatohepatitis), Mazence; Lipid metabolism stimulator (liver cirrhosis/steatosis/steatohepatitis), Mazence

Indication

Disease Entry	ICD 11	Status	REF
Fatty liver disease	DB92.Z	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DM3RBJW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting AMP-activated protein kinase (AMPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acadesine	DM1RMF5	Diabetic complication	5A2Y	Phase 3	[3]
Imeglimin	DMMQFG2	Diabetic complication	5A2Y	Phase 2	[4]
PXL-770	DMNSRY7	Non-alcoholic fatty liver disease	DB92	Phase 2	[5]
ENERGI-F701	DMMIHSO	Alopecia	ED70	Phase 2	[6]
O-304	DMXM34I	Type 2 diabetes	5A11	Phase 2	[7]
IM156	DM4MY9C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
Phenformin	DMQ52JG	Diabetic complication	5A2Y	Withdrawn from market	[9]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[10]
PMID23639540C13a	DMLXOAQ	Discovery agent	N.A.	Investigative	[11]
SU 6656	DMF1P6W	Discovery agent	N.A.	Investigative	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
AMP-activated protein kinase (AMPK)	TTLAFZV	AAPK1_HUMAN; AAKB1_HUMAN; AAKG1_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035046)
2	Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.Mol Pharmacol.2007 Jul;72(1):62-72.
3	Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother. 2008 Aug;9(12):2137-44.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032542)
5	Clinical pipeline report, company report or official report of Poxel SA.
6	Clinical pipeline report, company report or official report of Energenesis Biomedical.
7	Clinical pipeline report, company report or official report of Betagenon.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59.
10	Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
11	Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
12	The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.