Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3ST2Y)

Drug Name

(2E, 6E)-farnesylbisphosphonate Drug Info

Synonyms

(2E, 6E)-farnesylbisphosphonate; GTPL3200; SCHEMBL8916061; SCHEMBL2875241; (e,e)-(4,8,12-trimethyl-3,7,11-tridecatrienylidene)bisphosphonic acid; [(3E,7E)-4,8,12-trimethyl-1-phosphonotrideca-3,7,11-trien-1-yl]phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9871730
TTD Drug ID: DM3ST2Y

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Geranyltranstransferase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[4]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[3]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[3]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[5]
Incadronate	DM3DSVJ	Hypercalcaemia	5B91.0	Approved	[6]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[7]
NERIDRONIC ACID	DMMPG5V	Bone disease	FC0Z	Approved	[8]
Zarnestra	DMF30HL	Acute myeloid leukaemia	2A60	Phase 3	[9]
GERANYLGERANYL DIPHOSPHATE	DMJZ0AM	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3200).
2	Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorg Med Chem. 2008 Jan 1;16(1):390-9.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.
5	Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24.
6	Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.
7	Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
8	Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95.
9	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.