Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM42B0C)

Drug Name
BMS-986253 Drug Info
Indication
Disease Entry ICD 11 Status REF
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Cross-matching ID
TTD Drug ID
DM42B0C

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Interleukin-8 (IL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
ABX-IL8 DMCZFMS Melanoma 2C30 Phase 2 [5]
MDX-018 DML5FX2 Autoimmune diabetes 5A10 Phase 1 [6]
R-ketoprofen DMHSUQ1 N. A. N. A. Discontinued in Phase 2 [4]
2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid DM54M6C Discovery agent N.A. Investigative [4]
2-(2-(2-chlorophenylamino)phenyl)acetic acid DMPLV3A Discovery agent N.A. Investigative [4]
2-(2-(2-fluorophenylamino)phenyl)acetic acid DMVQ68F Discovery agent N.A. Investigative [4]
2-(2-(2-chlorophenoxy)phenyl)acetic acid DMBP1TQ Discovery agent N.A. Investigative [4]
2-(2-(2-fluorophenoxy)phenyl)acetic acid DMDSUR2 Discovery agent N.A. Investigative [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HUMAN interleukin 8 (IL8) TT3JF7X IL8_HUMAN Inhibitor [1]
Interleukin-8 (IL8) TTCTE1G IL8_HUMAN Inhibitor [3]

References

1 ClinicalTrials.gov (NCT04347226) Anti-Interleukin-8 (Anti-IL-8) for Patients With COVID-19. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT04347226) Anti-Interleukin-8 (Anti-IL-8) for Patients With COVID-19. U.S. National Institutes of Health.
3 Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer. 2019 Sep 5;7(1):240.
4 Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
5 Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34.
6 Company report (Genmab)