Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM43ABN)

• Drug Name: Provitamin D3 Drug Info
• Synonyms: Cholesta-5,7-dien-3-ol; Cholesta-5,7-dien-3-ol, (3b)-; Cholesta-5,7-dien-3beta-ol; Dehydrocholesterin; Dehydrocholesterol; Provitamin D3; UCTLRSWJYQTBFZ-DDPQNLDTSA-N; delta5,7-Cholesterol; delta7-Cholesterol; (-)-7-Dehydrocholesterol; (3beta)-Cholesta-5,7-dien-3-ol; 434-16-2; 5,7-Cholestadien-3-beta-ol; 5,7-Cholestandien-3beta-ol; 5,7-cholestadien-3beta-ol; 7,8-Didehydrocholesterol; 7-DHC; 7-Dehydrocholesterin; 7-Dehydrocholesterol; 7-dehydro-cholesterol; CHEBI:17759; NSC 18159; BK1IU07GKF; UNII-BK1IU07GKF
• Cross-matching ID:
  PubChem CID: 439423
  ChEBI ID: CHEBI:17759
  CAS Number: CAS 434-16-2
  TTD Drug ID: DM43ABN
  INTEDE Drug ID: DR2481

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 124 (cyp124)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[1]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[3]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[6]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[12]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 124 (cyp124) Main DME	DE28NZ9	CP124_MYCTU	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Regulation of Drug Effects	[2]

References

• [1] Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209.
• [2] Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. Hum Mol Genet. 2006 Mar 15;15(6):839-51. doi: 10.1093/hmg/ddl003. Epub 2006 Jan 30.
• [3] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [4] Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro. J Cell Mol Med. 2018 Feb;22(2):873-882. doi: 10.1111/jcmm.13373. Epub 2017 Oct 3.
• [5] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [6] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [7] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [8] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [9] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [10] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [11] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [12] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.