Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4QFXJ)

Drug Name

Sodium Tetradecyl Sulfate Drug Info

Synonyms

STDS; Trombavar; Monotetradecylsulfate sodium salt; Natri tetradecylsulfas; Natrii tetradecyclis sulfas; Sodium myristyl sulfate; Sodium tetradecyl sulphate; Sodium tetradecylsulfate; Sotradecol Sodium; Tetradecyl sodium sulfate; Niaproof 4; Tesapon K 14; Texapon K 14; Myristyl sulfate, sodium salt; Natrii tetradecyclis sulfas [INN-Latin]; Tetradecilsulfato sodico [INN-Spanish]; Tetradecyl sulfate de sodium [INN-French]; Tetradecyl sulfate, sodium salt; Fibro-Vein (TN); S.T.D; Sulfuric acid, monotetradecyl ester, sodium salt; Sulfuric acid, myristyl ester, sodium salt; S.T.D.; 1-Tetradecanol, 1-(hydrogen sulfate), sodium salt (1:1); 1-Tetradecanol, hydrogen sulfate, sodium salt

Indication

Disease Entry	ICD 11	Status	REF
Hemangioma	2E81-2F2Y	Approved	[1]
Varicose and spider veins of leg	BD74.1	Approved	[1]
Varicose veins	BD74-BD75	Approved	[2]

Therapeutic Class

Sclerosing Agents

Cross-matching ID

PubChem CID: 23665770
CAS Number: CAS 1191-50-0
TTD Drug ID: DM4QFXJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Vitamin K-dependent protein C (PROC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ancrod	DMK2Y4V	Blood forming organ disorder	JB64.1	Phase 3	[4]
3K3A-APC	DMTLR6Y	Cerebrovascular ischaemia	8B1Z	Phase 2	[5]
GED-aPC	DM041IZ	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 1	[6]
RPR-120844	DM1V0MD	Discovery agent	N.A.	Investigative	[7]
RPR-118071	DM61VHF	Discovery agent	N.A.	Investigative	[7]
PMID24418773C37	DMG4NQV	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin K-dependent protein C (PROC)	TTZUXYS	PROC_HUMAN	Inhibitor	[3]

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References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040541.
2	Sodium Tetradecyl Sulfate FDA Label
3	Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
4	Ancrod (Arvin) as an alternative to heparin anticoagulation for cardiopulmonary bypass. Anesthesiology. 1989 Dec;71(6):870-7.
5	Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012;18(27):4215-22.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2396).
7	Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem. 1999 Sep 9;42(18):3557-71.
8	Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg Med Chem Lett. 2014 Feb 1;24(3):821-7.