Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM52ITO)

Drug Name
NI-57 Drug Info
Synonyms
CHEMBL3752151; 1883548-89-7; 4-Cyano-~{n}-(1,3-Dimethyl-2-Oxidanylidene-Quinolin-6-Yl)-2-Methoxy-Benzenesulfonamide; GTPL8573; SCHEMBL17560720; MolPort-039-101-322; NI 57; EX-A1876; BDBM50157570; ZINC254286814; AKOS027470204; NCGC00483115-01; NI-57, > HY-19537; CS-0015636; 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-methoxybenzenesulfonamide; 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzenesulfonamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91827373
TTD Drug ID
DM52ITO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bromodomain-containing protein 1 (BRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
OF-1 DMK8LEC Discovery agent N.A. Investigative [4]
Drug(s) Targeting Bromodomain and PHD finger containing 1 (BRPF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25408830C3 DM8SBR2 Discovery agent N.A. Investigative [5]
OF-1 DMK8LEC Discovery agent N.A. Investigative [2]
PMID25408830C1 DM5GL23 Discovery agent N.A. Investigative [5]
PMID25974391C34 DMGWZA3 Discovery agent N.A. Investigative [6]
PMID25408830C2 DM20E13 Discovery agent N.A. Investigative [5]
PFI-4 DMPKXNZ Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain and PHD finger containing 1 (BRPF1) TTT46BN BRPF1_HUMAN Inhibitor [2]
Bromodomain and PHD finger containing 3 (BRPF3) TT1CHFI BRPF3_HUMAN Inhibitor [3]
Bromodomain-containing protein 1 (BRD1) TTT09OB BRD1_HUMAN Inhibitor [4]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8573).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2730).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2731).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2724).
5 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.
6 Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.