Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM537OH)

• Drug Name: Clobenpropit Drug Info
• Synonyms: clobenpropit; 145231-45-4; Vuf-9153; Vuf 9153; UNII-RKU631JF4H; S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea; CHEBI:64177; RKU631JF4H; 3-(1h-imidazol-5-yl)propyl n'-(4-chlorobenzyl)carbamimidothioate; 3-(1H-imidazol-4-yl)propyl ((4-chlorophenyl)methyl)carbamimidothioate; Carbamimidothioic acid, ((4-chlorophenyl)methyl)-, 3-(1H-imidazol-4-yl)propyl ester; 3-(1H-imidazol-4-yl)propyl N-(4-chlorobenzyl)carbamimidothioate; Carbamimidothioic acid,N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 2790
  ChEBI ID: CHEMBL14690
  CAS Number: CAS 145231-45-4
  TTD Drug ID: DM537OH

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine H4 receptor (H4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3893787	DMC2FAL	Atopic dermatitis	EA80	Phase 2	[6]
JNJ-38518168	DM9UMIO	Plaque psoriasis	EA90.0	Phase 2	[7]
UR-63325	DME6X27	Allergic rhinitis	CA08.0	Phase 2	[8]
Thioperamide	DM8S593	Cognitive impairment	6D71	Terminated	[9]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[10]
impromidine	DMTDRPM	Discovery agent	N.A.	Investigative	[11]
burimamide	DMZ2VYG	Discovery agent	N.A.	Investigative	[12]
Imetit	DMMJ6NS	Discovery agent	N.A.	Investigative	[13]
[125I]iodophenpropit	DMN4ABU	Discovery agent	N.A.	Investigative	[14]
(R)-alpha-methylhistamine	DMKAW4P	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[16]
SUVN-G3031	DM3BO8G	Cognitive impairment	6D71	Phase 3	[17]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[18]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[19]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[20]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[21]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[22]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[23]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[21]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[24]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[29]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[30]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[38]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[39]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[40]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[41]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[42]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Antagonist	[2]
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Agonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[4]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Gene/Protein Processing	[5]

References

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