Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM53VA8)

Drug Name

CVT-7124 Drug Info

Synonyms

CVT-7124; CHEMBL251876; SCHEMBL1945825; BDBM50233088; 1-ethyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Adenosine A2b receptor (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[2]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[2]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[3]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[4]
YT-146	DM3YVKQ	Hypertension	BA00-BA04	Phase 2	[5]
AB928	DMDOXMN	Metastatic colorectal cancer	2B91	Phase 1/2	[6]
KF-17837	DMQ6DLZ	Parkinson disease	8A00.0	Phase 1	[7]
Xanthine	DMFBOQ7	Apnea	MD11.0	Phase 1	[8]
CVT-6883	DMY84TW	Asthma	CA23	Phase 1	[9]
PBF-1129	DMOPGXM	Non-small-cell lung cancer	2C25.Y	Phase 1	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[1]

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References

1	Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Clinical pipeline report, company report or official report of Klus Pharma
4	2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203.
5	Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. J Med Chem. 1993 Nov 12;36(23):3731-3.
8	Role of adenosine in asthma. Drug Dev Res. 1996;39:333-6.
9	GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.