Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5J64S)

Drug Name

Miglustat Drug Info

Synonyms

BuDNJ; Butyldeoxynojirimycin; Miglustatum; NBV; Vevesca; Zavesca; Miglustat [USAN]; OGT 918; SC 48334; SC48334; Miglustat, Hydrochloride; N-Butyl deoxynojirimycin; N-Butyl dnj; N-Butyldeoxynojirimycin; N-Butylmoranoline; NB-DNJ; OGT-918; SC-48334; Zavesca (TN); Miglustat (USAN/INN); N-Bu-DNJ; N-Butyl-DNJ; N-Butyl-deoxynojirimycin; N-(n-Butyl)deoxynojirimycin; N-butyl-1-deoxynojirimycin; N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-N-butylimino-D-glucitol

Indication

Disease Entry	ICD 11	Status	REF
Niemann-Pick disease type C		Approved	[1]
Type 1 gaucher disease	5C56.0Y	Approved	[2]
Gaucher disease	5C56.0Y	Investigative	[1]

Therapeutic Class

Anti-HIV Agents

Cross-matching ID

PubChem CID: 51634
ChEBI ID: CHEMBL1029
CAS Number: CAS 72599-27-0
TTD Drug ID: DM5J64S
ACDINA Drug ID: D00434

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Ceramide glucosyltransferase (UGCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eliglustat tartrate	DMSRZAO	Metabolic disorder	5C50-5D2Z	Approved	[4]
Venglustat	DMLPEZS	Fabry disease	5C56.01	Phase 2	[5]
N-butylgalactonojirimycin	DMB06TA	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ceramide glucosyltransferase (UGCG)	TTPHEX3	CEGT_HUMAN	Inhibitor	[3]

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References

1	Miglustat FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4841).
3	Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies. Clin Ther. 2007 Aug;29(8):1645-54.
4	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. J Biol Chem. 2007 Nov 9;282(45):32655-64.