Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5RAB9)

Drug Name
RG-7234 Drug Info
Synonyms R-7234; RO-5027838; 11-beta HSD 2 (type 2 diabetes), Roche; 11-beta hydroxysteroid dehydrogenase inhibitor 2 (type 2 diabetes), Roche
Indication
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM5RAB9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[(125)I] RB129 DMX0G7E Discovery agent N.A. Investigative [3]
3-acetyl-11-keto-beta-boswellic acid DMGO2D7 Discovery agent N.A. Investigative [4]
11-keto-beta-boswellicacid DMM6CJI Discovery agent N.A. Investigative [4]
Ganoderic acid A DM42EVG Discovery agent N.A. Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) TT9H85R DHI2_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00823680) A Study of RO5093151 and RO5027838 in Patients With Type 2 Diabetes Mellitus on a Stable Dose of Metformin. U.S. National Institutes of Health.
2 New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).
3 Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Oncogene. 2003 Mar 20;22(11):1663-7.
4 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.