Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6FEMV)

Drug Name

YH-1238 Drug Info

Synonyms

195889-55-5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Gastric H(+)/K(+) ATPase (Proton pump)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[2]
Pantoprazole	DMSVOCZ	Gastrinoma	2C10.1	Approved	[2]
Dexlansoprazole	DM1DBV5	Erosive esophagitis	DA25.0	Approved	[2]
Esomeprazole	DM7BN0X	Cystic fibrosis	CA25	Approved	[2]
Vonoprazan	DMO6315	Helicobacter infection	DA42-DA63	Approved	[3]
RQ-00000004	DM9T8OF	Gastroesophageal reflux disease	DA22.Z	Phase 3	[4]
YH-4808	DMCHFB0	Duodenal ulcer	DA63	Phase 2	[5]
S-tenatoprazole	DMJ1DIB	Peptic ulcer	DA61	Phase 2	[6]
AZD-0865	DMM0N1F	Gastrointestinal disease	DE2Z	Phase 2	[7]
LEMINOPRAZOLE	DMBKNJT	Ulcerative colitis	DD71	Discontinued in Preregistration	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastric H(+)/K(+) ATPase (Proton pump)	TTLOKXP	ATP4A_HUMAN; ATP4B_HUMAN	Modulator	[1]

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References

1	Compositions for improving gastrointestinal nutrient and drug absorption
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2008
4	N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.
5	Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end! Neurogastroenterol Motil.2012 Aug;24(8):697-704.
6	Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in heal... Aliment Pharmacol Ther. 2004 Mar 15;19(6):655-62.
7	Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.
8	Vasoinhibitory effect of leminoprazole, a H+,K(+)-ATPase inhibitor, on rat aortic rings. Gen Pharmacol. 1996 Jan;27(1):117-21.