Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6GSI1)

Drug Name

HBX19818 Drug Info

Synonyms

HBX 19818; 1426944-49-1; CHEMBL2398213; 9-Chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-2-acridinecarboxamide; N-(3-(benzyl(methyl)amino)propyl)-9-chloro-5,6,7,8-tetrahydroacridine-2-carboxamide; N-[3-[benzyl(methyl)amino]propyl]-9-chloro-5,6,7,8-tetrahydroacridine-2-carboxamide; SCHEMBL20007093; BDBM50436150; HBX-19818; NCGC00378705-01; HY-17540; J3.502.626F

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

Cross-matching ID

PubChem CID: 73349008
TTD Drug ID: DM6GSI1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Herpesvirus ubiquitin-specific protease (HAUSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26077642-Compound-Vif2	DMYXIS7	N. A.	N. A.	Patented	[2]
PMID26077642-Compound-Vif1	DMS9KCF	N. A.	N. A.	Patented	[2]
ADC-03	DM21I35	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
P22077	DMD8JIC	Inflammation	1A00-CA43.1	Preclinical	[4]
ADC-01	DM19R28	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
P5091	DMGIR3F	Solid tumour/cancer	2A00-2F9Z	Preclinical	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpesvirus ubiquitin-specific protease (HAUSP)	TTXU3EQ	UBP7_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.
2	Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208.
3	Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics. Cancers (Basel). 2020 Jun 15;12(6):1579.
4	P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6. Aging (Albany NY). 2020 Jun 9;12(11):10969-10982.
5	USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochem Pharmacol. 2017 May 1;131:29-39.