Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6QHIA)

Drug Name

5-fluoro-6-amino-UMP Drug Info

Synonyms

6-Amino-5-Fluorouridine 5'-(Dihydrogen Phosphate); FNU; uridine derivative, 42; SCHEMBL1363501; CHEMBL474165; BDBM27945; {[(2R,3S,4R,5R)-5-(6-amino-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16666487
TTD Drug ID: DM6QHIA

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Orotidine 5'-monophosphate decarboxylase (UMPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[2]
6-Hydroxyuridine-5'-Phosphate	DMDMNQV	Discovery agent	N.A.	Investigative	[3]
Pyrazofurin	DMVJLSM	Discovery agent	N.A.	Investigative	[4]
5-fluoro-6-azido-UMP	DMZLJRS	Discovery agent	N.A.	Investigative	[1]
5-fluoro-6-iodo-UMP	DM3LMIS	Discovery agent	N.A.	Investigative	[1]
5-Fluoro-6-ethyluridine-5'-O-monophosphate	DMTAZ71	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Orotidine 5'-monophosphate decarboxylase (UMPS)	TTAFJUD	UMPS_HUMAN	Inhibitor	[1]

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References

1	Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58.
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.