Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6XGFE)

• Drug Name: NC1153 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Renal transplantation	NE84	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 373395
  TTD Drug ID: DM6XGFE

Molecule-Related Drug Atlas

Drug(s) Targeting Janus kinase 3 (JAK-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[3]
Ritlecitinib	DMYKNME	Alopecia areata	ED70.2	Approved	[4]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[5]
VX-509	DM2U3MX	Rheumatoid arthritis	FA20	Phase 2/3	[6]
Cerdulatinib	DMSCR2H	B-cell lymphoma	2A86	Phase 2	[4]
ATI-501	DMTY6OF	Alopecia	ED70	Phase 2	[7]
ATI-502	DM8NODR	Alopecia	ED70	Phase 2	[8]
TD-8236	DMTOMJN	Asthma	CA23	Phase 2	[9]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[10]
SNA-125	DM8L1GJ	Atopic dermatitis	EA80	Phase 1	[4]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[2]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[2]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[12]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[13]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[2]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[2]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[2]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Gene/Protein Processing	[2]

References

• [1] Immunotherapy for De Novo renal transplantation: what's in the pipeline Drugs. 2006;66(13):1665-84.
• [2] A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049).
• [6] Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
• [7] Clinical pipeline report, company report or official report of Aclaris Therapeutics.
• [8] ClinicalTrials.gov (NCT03759340) ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT). U.S. National Institutes of Health.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [10] The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 1;23(9):2313-2324.
• [11] NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
• [12] Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
• [13] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [14] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.