Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM70RDZ)

Drug Name

Metrenperone Drug Info

Synonyms

Metrenperone; 81043-56-3; UNII-W1O4FV809G; W1O4FV809G; R 50 970; Metrenperona; Metrenperonum; 3-[2-[4-(4-Fluorobenzoyl)-1-piperidyl]ethyl]-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one; Metrenperonum [INN-Latin]; Metrenperona [INN-Spanish]; Sinomedol; Metrenperone [USAN:INN:BAN]; 3-(2-(4-(4-Fluorobenzoyl)-1-piperidyl)ethyl)-2,7-dimethyl-4H-pyrido(1,2-a)pyrimidin-4-one; EINECS 279-678-7; Metrenperone (USAN/INN); AC1Q4NI9; AC1L2H8G; SCHEMBL2109868; CHEMBL2104852; BDBM82382; DTXSID20230867; ZINC537997; NSC_72005; CAS_72005

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 72005
CAS Number: CAS 81043-56-3
TTD Drug ID: DM70RDZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting 5-HT 2 receptor (5HT2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mianserin	DMVKA4O	Depression	6A70-6A7Z	Approved	[2]
Cyclobenzaprine	DM1YBRM	Depression	6A70-6A7Z	Approved	[3]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[4]
Ketanserin	DMVLMW6	Hypertension	BA00-BA04	Approved	[5]
Bis(olanzapine) pamoate monohydrate	DME76AP	Psychotic disorder	6A20-6A25	Phase 3	[6]
FKB01MD	DM2O7NM	N. A.	N. A.	Phase 2	[7]
Nexopamil	DML5S71	Hypertension	BA00-BA04	Phase 2	[8]
TGWOOAA	DMI57ZA	Generalized anxiety disorder	6B00	Phase 2	[9]
TGOF02N	DMQ6ANE	Schizophrenia	6A20	Phase 2	[10]
AMAP-102	DM7CD8Z	Arthritis	FA20	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2 receptor (5HT2R)	TTYSN63	NOUNIPROTAC	Antagonist	[1]

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References

1	Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Vet J. 1999 Jan;157(1):31-7.
2	5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats. Neurosci Lett. 2008 Jan 17;430(3):191-6.
3	Torticollis under Cyclobenzaprine. Pharmacology. 2009 Jul 8;84(2):91-92.
4	Pharmacological effects of zotepine and other antipsychotics on the central 5-HT2 receptors. Pharmacopsychiatry. 1993 Mar;26(2):53-8.
5	Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L531-8.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.
9	Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals.
10	Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals.
11	Clinical pipeline report, company report or official report of Anamar.