Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7RPSG)

Drug Name

BF-1 Drug Info

Synonyms

BF-1; 518980-66-0; Piperidine, 4-(6-ethoxy-1-methoxy-9H-thioxanthen-9-ylidene)-1-methyl-; SCHEMBL4475418; GTPL8424; CTK1E4820; DTXSID70437783; SB18757; L022232

Indication

Disease Entry	ICD 11	Status	REF
Cluster headache	8A81.0	Phase 1	[1]
Migraine	8A80	Phase 1	[1]

Cross-matching ID

PubChem CID: 10287037
CAS Number: CAS 518980-66-0
TTD Drug ID: DM7RPSG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting 5-HT receptor (5HTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[3]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[4]
Ramosetron	DMH7GN8	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[3]
Pizotyline	DMV74ZH	Headache	8A80-8A84	Approved	[4]
Tandospirone	DMPHWU6	Anxiety disorder	6B00-6B0Z	Approved	[3]
Nafronyl	DMVMQ1L	Cerebrovascular ischaemia	8B1Z	Approved	[4]
ITI-007	DMUQ1DO	Depression	6A70-6A7Z	Phase 3	[5]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[6]
MIN-117	DMSLIW6	Major depressive disorder	6A70.3	Phase 2	[5]
Lu-AA34893	DM2ZUXK	Anxiety disorder	6B00-6B0Z	Phase 2	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT receptor (5HTR)	TT85JO3	NOUNIPROTAC	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8424).
2	Serotonin (5-HT2B) receptor. SciBX 4(19); doi:10.1038/scibx.2011.534. May 12 2011
3	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418.
7	Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105).