General Information of Drug (ID: DM7WYXJ)

Drug Name
P-1101 Drug Info
Synonyms
Pegylated interferon alpha (hepatitis B and C virus infection), PharmaEssentia; Pegylated interferon alpha-2b (polycythemia vera), AOP Orphan; PEG-INF-alpha (hepatitis B and C virus infection), PharmaEssentia; PEG-P-IFN-alpha-2b
Indication
Disease Entry ICD 11 Status REF
Essential thrombocythemia 3B63.1Z Phase 3 [1]
Hepatitis B virus infection 1E51.0 Phase 3 [2]
Myelofibrosis 2A20.2 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM7WYXJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Interferon-alpha 2 (IFNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Peginterferon alfa-2b DMAP58Y Hepatitis C virus infection 1E51.1 Approved [4]
Interferon Alfa-2b DMWCQP4 Melanoma 2C30 Approved [4]
Peginterferon alfa-2a DMJI3BA Chronic hepatitis B virus infection Approved [4]
Albinterferon alfa-2b DMK0QW6 Hepatitis C virus infection 1E51.1 Phase 3 [5]
Interferon alpha 2a DMOTH6V Hepatitis C virus infection 1E51.1 Phase 3 [6]
Hebergel DMQTLVB Virus infection 1A24-1D9Z Phase 3 [7]
Interferon alpha-2b DMVACTU Hepatitis C virus infection 1E51.1 Phase 2 [8]
Novaferon DMEHOI1 Colorectal cancer 2B91.Z Phase 2 [9]
Instiladrin DMNKAFQ Bladder cancer 2C94 Phase 2 [10]
CIGB-128 DMB2MKU Basal cell carcinoma 2C32 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interferon-alpha 2 (IFNA2) TTSIUJ9 IFNA2_HUMAN Modulator [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01949805) Pegylated Interferon Alpha-2b Versus Hydroxyurea in Polycythemia Vera. U.S. National Institutes of Health.
3 Effects of PEG-interferon-alpha-2A on Schistosoma mansoni infection in mice. J Parasitol. 2010 Aug;96(4):703-8.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C. Curr Med Res Opin. 2009 Apr;25(4):991-1002.
6 Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. Blood. 1988 Aug;72(2):655-60.
7 Evaluation of recombinant human interferon alpha-2b structure and stability by in-gel tryptic digestion, H/D exchange and mass spectrometry. J Pharm Biomed Anal. 2006 Feb 24;40(3):781-7.
8 Clinical pipeline report, company report or official report of Avarx.
9 Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-alpha, shows antitumor effect in vitro and in vivo. Cancer Cell Int. 2014; 14: 8.
10 ClinicalTrials.gov (NCT01687244) Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer. U.S. National Institutes of Health.
11 Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial.BMC Pharmacol Toxicol.2012 Dec 28;13:20.