Details of the Drug-Related molecule(s) Interaction Atlas

BRN-2330710 Drug Info

Pyren-2-ylmethanol; 2-(Hydroxymethyl)pyrene; 2-Hydroxymethylpyrene; 2-Pyrenemethanol; SCHEMBL9609744; 24471-48-5; 4-06-00-05008 (Beilstein Handbook Reference); AC1L3U62; CCRIS 7295; CTK1A3560; DTXSID90179234

Cross-matching ID

PubChem CID

146932

CAS Number

CAS 24471-48-5

TTD Drug ID

DM87VP6

INTEDE Drug ID

DR2005

General Information of Drug (ID: DM87VP6)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

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Drug(s) Metabolized By Alcohol dehydrogenase class-I gamma (ADH1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[1]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[1]
Pyrene-1-aldehyde	DMEF6IP	N. A.	N. A.	Investigative	[1]
Hydroxymethylpyrene	DMPGAR2	N. A.	N. A.	Investigative	[1]
Pyrenemethanol	DMGJ0RM	N. A.	N. A.	Investigative	[1]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[1]
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Drug(s) Metabolized By Alcohol dehydrogenase class-II (ADH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[3]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[1]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[1]
Pyrene-1-aldehyde	DMEF6IP	N. A.	N. A.	Investigative	[1]
Hydroxymethylpyrene	DMPGAR2	N. A.	N. A.	Investigative	[1]
Pyrenemethanol	DMGJ0RM	N. A.	N. A.	Investigative	[1]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Substrate	[1]
Alcohol dehydrogenase class-I gamma (ADH1C)	DEM1HNL	ADH1G_HUMAN	Substrate	[1]

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References

1	Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
2	Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
3	13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? Biochem Biophys Res Commun. 2003 Mar 28;303(1):273-8.