Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM90XQC)

Drug Name
CTX001 Drug Info
Indication
Disease Entry ICD 11 Status REF
Beta thalassemia 3A50.2 Phase 1/2 [1]
Sickle-cell disorder 3A51 Phase 1/2 [2]
Cross-matching ID
TTD Drug ID
DM90XQC

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B-cell lymphoma/leukemia 11A (BCL11A) TTR61MW BC11A_HUMAN Not Available [3]

References

1 ClinicalTrials.gov (NCT03655678) A Safety and Efficacy Study Evaluating CTX001 in Subjects With Transfusion-Dependent beta-Thalassemia. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03745287) A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease. U.S. National Institutes of Health.
3 Off-the-shelf' allogeneic CAR T cells: development and challenges. Nat Rev Drug Discov. 2020 Mar;19(3):185-199.