Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA46DO)

Drug Name
INS-117548 Drug Info
Synonyms ROCKI/ROCKII inhibitor (ophthalmic solution, ocular hypertension/glaucoma), Wisconsin Alumni Research Foundation (WARF)/Inspire
Indication
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMA46DO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Rho-associated protein kinase 2 (ROCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Belumosudil DM548TK Graft-versus-host disease 4B24 Approved [3]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [4]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [5]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [5]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [5]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [5]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [5]
PMID28048944-Compound-6 DM5RCBV N. A. N. A. Patented [5]
PMID28048944-Compound-2 DM9ZXOP N. A. N. A. Patented [5]
Tricyclic compound 7 DME84S5 N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Netarsudil DM0LPI9 Open-angle glaucoma 9C61 Approved [6]
SAR-407899 DMF95KD Diabetic nephropathy GB61.Z Phase 2 [7]
H-1152 DM8XH3S Pulmonary arterial hypertension BB01.0 Phase 2 [8]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [4]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [5]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [5]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [5]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [5]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [5]
PMID28048944-Compound-6 DM5RCBV N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rho-associated protein kinase 1 (ROCK1) TTZN7RP ROCK1_HUMAN Modulator [2]
Rho-associated protein kinase 2 (ROCK2) TTGWKQJ ROCK2_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT00767793) A Placebo-Controlled Study of INS117548 Ophthalmic Solution in Subjects With Glaucoma (P08650). U.S. National Institutes of Health.
2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3 Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9.
4 Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
5 Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515.
6 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
7 The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. J Hypertens. 2012 May;30(5):980-9.
8 Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.