Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA7JB6)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Protein-tyrosine phosphatase SHP-1 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-87877	DMEYKXL	Discovery agent	N.A.	Patented	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein-tyrosine phosphatase SHP-1 (PTPN6)	TT369M5	PTN6_HUMAN	Inhibitor	[1]

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References

1	Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). US9522881.
2	Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs. US8987474.