Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAQ2LK)

• Drug Name: Teicoplanin Drug Info
• Synonyms: Targocid (TN)

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]
Skin infection	1F28-1G0Z	Investigative	[2]

• Cross-matching ID:
  PubChem CID: 133065662
  CAS Number: CAS 61036-62-2
  TTD Drug ID: DMAQ2LK
  INTEDE Drug ID: DR1542

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Cell membrane (Bact CM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[8]
Delamanid	DMXE76K	Multi-drug resistant tuberculosis	MG52.00	Approved	[9]
Diphtheria-tetanus vaccine	DM0FSIM	Clostridium infection	1A04	Approved	[10]
D2A21	DMYJ2QB	Burn and burn infection	ND90-NE2Z	Phase 3	[11]
DPK-060	DM059CZ	Atopic dermatitis	EA80	Phase 2	[12]
Brilacidin	DMXI9BP	Acute bacterial skin infection	1C41	Phase 2	[13]
LTX-109	DMXEQ0R	Bacterial infection	1A00-1C4Z	Phase 2	[14]
Friulimicin	DMUI8F3	Bacterial infection	1A00-1C4Z	Phase 1	[15]
IDR-1018	DM1RNT7	Bacterial infection	1A00-1C4Z	Phase 1	[16]
Lotilibcin	DMDLTCU	Bacterial infection	1A00-1C4Z	Phase 1	[17]

Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[22]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[23]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[24]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[25]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[26]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[27]

Drug(s) Metabolized By VanA ligase (vanA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[5]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[5]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[5]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[6]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[7] , [6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Cell membrane (Bact CM)	TTXT4D5	NOUNIPROTAC	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Substrate	[4]
VanA ligase (vanA)	DEOFMQ7	Q0WYK7_ENTFL	Substrate	[5]
VanA ligase (vanA)	DEO97D6	VANA_ENTFC	Substrate	[5]
VanA ligase (vanA)	DEN6VO0	A0A376GZ73_ENTGA	Substrate	[6]
VanA ligase (vanA)	DEO8E75	A0A437UFE2_ENTAV	Substrate	[5]
VanA ligase (vanA)	DESOXHP	A0A4U9YK96_ENTCA	Substrate	[7] , [6]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] The role of dalbavancin in the treatment of acute bacterial skin and skin structure infections (ABSSSIs). Expert Rev Anti Infect Ther. 2020 May;18(5):415-422.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86.
• [5] Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71.
• [6] Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.
• [7] vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11.
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [9] Compassionate use of delamanid in adults and children for drug-resistant tuberculosis: 5-year update. Eur Respir J. 2021 May 20;57(5):2002483.
• [10] 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
• [11] In Vitro Microbicidal Activities of Cecropin Peptides D2A21 and D4E1 and Gel Formulations Containing 0.1 to 2% D2A21 against Chlamydia trachomatis. Antimicrob Agents Chemother. 2002 January; 46(1): 34-41.
• [12] The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 2015 Feb;14(2):111-29.
• [13] Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. Antimicrob Agents Chemother. 2014 Sep;58(9):5136-45.
• [14] A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95.
• [15] Model membrane approaches to determine the role of calcium for the antimicrobial activity of friulimicin. Int J Antimicrob Agents. 2011 Mar;37(3):256-60.
• [16] Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection. PLoS One. 2012; 7(8): e39373.
• [17] Bioactive natural products from Lysobacter. Nat Prod Rep. 2012 November 8; 29(11): 1277-1287.
• [18] Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
• [19] Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
• [20] Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
• [21] Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
• [22] Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
• [23] Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
• [24] Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
• [25] Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
• [26] Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.
• [27] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.