Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBLSX3)

Drug Name

EPB-415 Drug Info

Synonyms

Ribavirin prodrug (hepatitis C virus infection), Epiphany

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase (IMPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[2]
Enteric-coated mycophenolate sodium	DMK659W	Transplant rejection	NE84	Approved	[3]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
IMS	DMFACQU	Inflammatory bowel disease	DD72	Discontinued in Phase 1	[5]
R-1518	DM2J5AO	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase (IMPDH)	TTCAQMW	NOUNIPROTAC	Modulator	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2625).
2	Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
3	Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients. Clin Sci (Lond). 2004 Jul;107(1):63-8.
4	Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene. 2005 Sep 1;24(38):5888-96.
5	The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock. 2009 Sep;32(3):258-62.
6	US patent application no. 2010,0092,479, Compositions and methods for treatment of viral diseases.