Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBM47Z)

Drug Name

Oxazolidinones Drug Info

Synonyms

2-Oxazolidone; Oxazolidin-2-one; 2-Oxazolidinone; 497-25-6; 1,3-Oxazolidin-2-one; Oxazolidinone; Oxazolidone; UNII-Z4D49W92PP; EINECS 207-840-9; NSC 35382; BRN 0106251; AI3-38980; CHEBI:1237; Z4D49W92PP; IZXIZTKNFFYFOF-UHFFFAOYSA-N; Carbamic acid, (2-hydroxyethyl)-, gamma-lactone; MFCD00005268; 2-Oxazolidone, 98%; WLN: T5MVOTJ; 51667-26-6; Carbamic acid, .gamma.-lactone; Oxazolidinones; SMR000857362; oxazolodinone; hydroxyoxazoline; 2-oxazolidinon; hydroxy-oxazoline; 2-Oxazolidine; oxazolidine-2-one; PubChem8624; ACMC-209upq; AC1Q6HSI

Indication

Disease Entry	ICD 11	Status	REF
Gram-positive bacterial infection	1B74-1G40	Phase 2	[1]

Cross-matching ID

PubChem CID: 73949
ChEBI ID: CHEBI:1237
CAS Number: CAS 497-25-6
TTD Drug ID: DMBM47Z

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Bacterial 16S ribosomal RNA (Bact 16S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[3]
Apramycin	DMU8QD2	Gram-negative bacterial infection	1B74-1G40	Phase 1	[4]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[4]
Hygromycin B	DMEZ92A	Discovery agent	N.A.	Investigative	[4]
Ribostamycin	DMXWUHA	Discovery agent	N.A.	Investigative	[4]
Neamine	DMNCU6H	Discovery agent	N.A.	Investigative	[4]
Butirosin B	DMR6GJK	Discovery agent	N.A.	Investigative	[4]
Aminodeoxykanamycin	DM79E2K	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Bacterial 23S ribosomal RNA (Bact 23S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[5]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[6]
Thiamphenicol	DMDRKH2	Bacterial infection	1A00-1C4Z	Approved	[7]
Lefamulin	DME6G97	Community-acquired pneumonia	CA40.Z	Approved	[8]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[9]
Spiramycin	DM20R5F	Bacterial infection	1A00-1C4Z	Approved	[10]
Macrolides	DM3BS97	Bacterial infection	1A00-1C4Z	Approved	[11]
Cethromycin	DMIGX84	Bacterial infection	1A00-1C4Z	Phase 3	[12]
EDP-420	DM5WZ0O	Bacterial infection	1A00-1C4Z	Phase 2	[13]
Micrococcin	DMJ4D1P	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 16S ribosomal RNA (Bact 16S rRNA)	TT38DW5	NOUNIPROTAC	Inhibitor	[2]
Bacterial 23S ribosomal RNA (Bact 23S rRNA)	TTLFGBV	NOUNIPROTAC	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00646958) Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections. U.S. National Institutes of Health.
2	Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.
3	Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26.
4	RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.
5	Company report (JMI Laboratories)
6	Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol. 2004 Dec;54(5):1287-94.
7	The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-9-13.
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
9	Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23.
10	The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
11	Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
12	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
13	EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May; 51(5): 1666-1670.