General Information of Drug (ID: DMBO2DC)

Drug Name
2MeSAMP Drug Info
Synonyms 2-methylthio-AMP; poly(2'-methylthioadenylic acid)
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
189762
CAS Number
CAS 70804-88-5
TTD Drug ID
DMBO2DC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
adenosine diphosphate DMFUHKP N. A. N. A. Investigative [3]
2MeSATP DMUE0W6 Discovery agent N.A. Investigative [3]
PPADS DMWHN3T Discovery agent N.A. Investigative [3]
2MeSADP DMGADQ1 Discovery agent N.A. Investigative [3]
ATPgammaS DMXHQIN Discovery agent N.A. Investigative [3]
MRS2211 DM2G5ZE Discovery agent N.A. Investigative [4]
[33P]2MeSADP DM218VZ Discovery agent N.A. Investigative [3]
MRS2603 DMNGC79 Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [5]
Prasugrel DM7MT6E Acute coronary syndrome BA41 Approved [6]
Brilinta DMBR01X Acute coronary syndrome BA41 Approved [7]
Cangrelor DM8JRH0 Thrombosis DB61-GB90 Approved [8]
INS-50589 DMKZUVC Cardiovascular disease BA00-BE2Z Phase 2 [9]
Elinogrel DMA4BRV Myocardial infarction BA41-BA43 Phase 1 [10]
ARL-67085 DMY5IM2 Thrombosis DB61-GB90 Phase 1 [11]
adenosine diphosphate DMFUHKP N. A. N. A. Investigative [5]
2MeSADP DMGADQ1 Discovery agent N.A. Investigative [2]
R-138727 DML49FI Discovery agent N.A. Investigative [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2Y purinoceptor 12 (P2RY12) TTZ1DT0 P2Y12_HUMAN Antagonist [2]
P2Y purinoceptor 13 (P2RY13) TT1FE3L P2Y13_HUMAN Antagonist [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1764).
2 Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9.
3 Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.
4 Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol. 2005 Jul 15;70(2):266-74.
5 P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22.
6 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
7 Clinical pipeline report, company report or official report of AstraZeneca (2009).
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328).
9 Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589. Platelets. 2007 Aug;18(5):346-56.
10 Elinogrel, a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events. Curr Opin Investig Drugs. 2010 Mar;11(3):340-8.
11 Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206.
12 Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost. 2005 Sep;94(3):593-8.