Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBTPDL)

Drug Name

MS453 Drug Info

Synonyms

2059892-29-2; N-(3-((6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide; MS-453

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting SET domain containing 8 (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MS2177	DMDEJBQ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[1]
nahuoic acid A	DM1LWMU	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2	Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J Med Chem. 2016 Nov 10;59(21):9881-9889.
3	Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Org Lett. 2013 Jan 18;15(2):414-7.