Details of the Drug

General Information of Drug (ID: DMD1E4J)

Drug Name
UNC0379
Synonyms
1620401-82-2; 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; 4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)
Indication
Disease Entry ICD 11 Status REF
Hepatocellular carcinoma 2C12.02 Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 413.6
Logarithm of the Partition Coefficient (xlogp) 4.3
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C23H35N5O2
IUPAC Name
6,7-dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine
Canonical SMILES
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC
InChI
InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26)
InChIKey
WEXCGGWTIDNVNT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
78357767
TTD ID
DB4D2N

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
SET domain containing 8 (KMT5A) TTGC95K KMT5A_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Gene/Protein Processing [2]
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) OT3SQMLU AN32B_HUMAN Gene/Protein Processing [2]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [2]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Gene/Protein Processing [2]
Apical endosomal glycoprotein (MAMDC4) OTTL3DWT AEGP_HUMAN Gene/Protein Processing [2]
Arginine-glutamic acid dipeptide repeats protein (RERE) OT3G4GBZ RERE_HUMAN Gene/Protein Processing [2]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Gene/Protein Processing [2]
Atrophin-1 (ATN1) OTNZFLKY ATN1_HUMAN Gene/Protein Processing [2]
BCL-6 corepressor-like protein 1 (BCORL1) OTPTFQN5 BCORL_HUMAN Gene/Protein Processing [2]
BolA-like protein 2 (BOLA2) OTVZP6YB BOLA2_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 2.7373 6.3587 1.2925 14.6011
ES1 GDSC2 1.145 3.1772 0.9841 22.686
EW-22 GDSC2 2.1538 3.842 1.8751 13.2467
ES8 GDSC2 2.163 3.8457 1.8836 13.1588
EW-3 GDSC2 2.4471 4.4536 1.927 11.7548
EW-1 GDSC2 3.0399 6.2697 1.6069 11.6869
EW-11 GDSC2 3.0586 7.2105 1.1541 14.3995
EW-24 GDSC2 3.1109 6.6359 1.4859 12.2162
EW-7 GDSC2 3.2352 4.9149 2.452 5.7654
SJSA-1 GDSC2 3.2509 7.9424 0.9523 15.0039
CHSA8926 GDSC2 3.3468 5.3701 2.3185 6.2813
SK-ES-1 GDSC2 3.6788 9.1497 0.6998 15.2005
EW-16 GDSC2 3.7594 7.483 1.5938 9.6977
EW-18 GDSC2 3.781 6.8238 1.9373 7.5117
CAL-72 GDSC2 3.9082 16.0751 -2.5729 27.9468
G-292 clone A141B1 GDSC2 3.9526 8.31 1.3321 10.7851
MHH-ES-1 GDSC2 4.0744 10.3703 0.4035 15.7279
A-673 GDSC2 4.1226 8.4587 1.3864 10.0298
MG-63 GDSC2 4.1394 7.8239 1.7105 8.0303
ES6 GDSC2 4.169 8.9685 1.1698 11.198
NY GDSC2 4.2006 9.9106 0.7281 13.6396
SK-PN-DW GDSC2 4.2837 6.43 2.4776 3.1114
U2OS GDSC2 4.4487 9.9642 0.8866 12.1345
NOS-1 [Human HNSCC] GDSC2 4.4509 11.2172 0.2711 15.4411
ES7 GDSC2 4.7559 7.3276 2.3503 3.0237
TC-71 GDSC2 4.8036 9.0261 1.5901 7.2818
ES4 GDSC2 4.8333 8.3889 1.9099 5.3691
HOS GDSC2 4.8968 11.6873 0.368 13.8586
CADO-ES1 GDSC2 5.0149 6.9967 2.6302 1.2889
HuO-3N1 GDSC2 5.098 14.0482 -0.6426 18.1586
HuO9 GDSC2 5.2192 13.2046 -0.1413 15.62
CAL-78 GDSC2 5.5114 7.3736 2.7031 0.6191
SaOS-2 GDSC2 5.7433 14.8913 -0.5901 16.4728
EW-13 GDSC2 5.7967 7.8945 2.625 0.6918
H-EMC-SS GDSC2 6.0839 9.5528 2.096 2.5348
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC2 1.6341 3.9877 1.2632 18.9544
FLO-1 GDSC2 3.337 10.6826 -0.3459 21.5253
ESO-26 GDSC2 3.7304 7.1918 1.7159 9.0194
SK-GT-4 GDSC2 3.9387 8.5966 1.1793 11.7313
OACM5.1 C GDSC2 4.0505 7.7642 1.6749 8.4615
OACP4 C GDSC2 4.5491 8.5415 1.6505 7.4635
KYSE-50 GDSC2 5.9077 8.5125 2.4351 1.2723
KYAE-1 GDSC2 6.0506 7.746 2.7759 0.2223
ESO-51 GDSC2 6.3512 8.2011 2.7269 0.2282
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 3.7536 6.4507 2.1011 6.559
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-5 GDSC2 1.9664 4.1262 1.5655 15.8163
GOTO GDSC2 2.3149 3.9663 1.9984 11.8597
CHP-134 GDSC2 2.3427 3.4986 2.2003 10.5897
Kelly GDSC2 2.4557 4.9016 1.7304 12.9112
NB(TU)1 GDSC2 3.1416 5.3944 2.1318 8.0757
GI-ME-N GDSC2 3.3314 7.1727 1.4044 12.0549
NB69 GDSC2 3.6456 5.848 2.3175 5.478
SJNB-13 GDSC2 3.6462 5.9577 2.2636 5.8148
SJNB-10 GDSC2 3.7494 6.0476 2.2969 5.3475
SK-N-DZ GDSC2 3.7658 7.7294 1.4763 10.4008
NH-12 GDSC2 3.8881 6.4335 2.209 5.5597
SJNB-12 GDSC2 3.9663 6.4758 2.2444 5.1601
SK-N-SH GDSC2 4.0068 6.7021 2.163 5.5675
SK-N-BE(2)-M17 GDSC2 4.0359 8.6133 1.2451 11.0903
SK-N-FI GDSC2 4.4921 10.4356 0.687 13.135
SJNB-14 GDSC2 4.725 10.8889 0.6345 12.8594
SiMa GDSC2 4.8064 7.3073 2.3882 2.742
CHP-212 GDSC2 4.9677 6.8845 2.6535 1.2356
SJNB-7 GDSC2 5.0561 15.3666 -1.3233 20.9987
TGW GDSC2 5.1221 14.4279 -0.8116 18.8166
SK-N-AS GDSC2 5.445 7.3783 2.6735 0.7574
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.1576 9.802 0.7492 13.6332
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1806 GDSC2 2.1248 7.1854 0.32 22.2914
CAL-148 GDSC2 2.3758 6.3921 0.9414 17.9375
JIMT-1 GDSC2 2.8829 7.0313 1.0898 15.3416
HCC70 GDSC2 3.243 5.8306 2.0013 8.5914
DU4475 GDSC2 3.3213 4.7938 2.5855 4.6644
MDA-MB-231 GDSC2 3.3725 6.6708 1.6894 10.1709
HCC1395 GDSC2 3.4437 7.4244 1.3713 11.9314
CAL-120 GDSC2 3.4955 6.2869 1.9815 7.9912
MDA-MB-453 GDSC2 3.6303 7.2079 1.6296 9.8218
MRK-nu-1 GDSC2 3.7614 5.3318 2.6555 3.1001
ZR-75-30 GDSC2 3.7822 6.5561 2.0706 6.6781
HDQ-P1 GDSC2 3.8912 7.0161 1.9251 7.3115
MCF-7 GDSC2 3.9981 6.9291 2.0461 6.3069
CAMA-1 GDSC2 4.0005 7.5818 1.7277 8.2603
HCC1500 GDSC2 4.0545 8.534 1.2984 10.7261
CAL-51 GDSC2 4.1781 9.4294 0.9491 12.4532
COLO 824 GDSC2 4.2212 7.3364 2.0057 6.0468
MDA-MB-157 GDSC2 4.3498 8.7575 1.4058 9.3661
MDA-MB-468 GDSC2 4.3714 10.5613 0.5354 14.2559
MDA-MB-175-VII GDSC2 4.4847 8.1017 1.8178 6.6069
AU565 GDSC2 4.7386 10.0284 1.0634 10.4559
Evsa-T GDSC2 4.7771 6.8039 2.5919 1.7377
MFM-223 GDSC2 4.8917 6.5369 2.7583 0.871
HCC38 GDSC2 4.9268 11.53 0.4663 13.2789
HCC1954 GDSC2 4.9323 6.9334 2.6161 1.4398
EFM-192A GDSC2 5.02 6.8298 2.7002 0.9901
MDA-MB-361 GDSC2 5.0458 9.9819 1.2958 8.4733
BT-483 GDSC2 5.0944 8.0213 2.2333 3.133
Hs 578T GDSC2 5.107 20.5201 -3.8386 28.3197
HCC1419 GDSC2 5.1286 6.8885 2.7258 0.8011
BT-549 GDSC2 5.1354 9.6088 1.5308 6.9622
BT-474 GDSC2 5.1366 7.0358 2.6714 1.0026
UACC-812 GDSC2 5.1763 13.6163 -0.3735 16.7891
HCC1187 GDSC2 5.1868 7.8358 2.3643 2.3346
HCC1143 GDSC2 5.2521 10.3311 1.2658 8.2252
MDA-MB-436 GDSC2 5.2832 8.4445 2.1515 3.2855
T-47D GDSC2 5.3691 9.4706 1.7398 5.3676
EFM-19 GDSC2 5.3807 7.6782 2.5266 1.371
MDA-MB-415 GDSC2 5.4209 7.4945 2.6181 0.9727
HCC1428 GDSC2 5.5186 7.0438 2.8263 0.2882
BT-20 GDSC2 5.5921 7.1395 2.8199 0.2759
OCUB-M GDSC2 5.8005 7.6722 2.7086 0.4536
CAL-85-1 GDSC2 6.2095 8.8195 2.4474 1.0047
HCC1937 GDSC2 7.1468 19.8595 -2.0171 19.0464
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 GDSC2 1.5076 5.2325 0.6222 23.0849
H4 GDSC2 1.5554 3.9216 1.2024 19.6376
ONS-76 GDSC2 1.8497 5.5091 0.8466 20.4523
42-MG-BA GDSC2 2.4987 5.1252 1.6675 13.1368
D283 Med GDSC2 2.9166 5.2478 2.0034 9.6055
GaMG GDSC2 3.1732 5.8515 1.9311 9.244
LN-18 GDSC2 3.6229 5.027 2.7053 3.1111
M059J GDSC2 3.6826 7.3739 1.5881 9.9366
8-MG-BA GDSC2 3.7067 5.319 2.6231 3.4237
MOG-G-UVW GDSC2 3.7765 6.3583 2.1639 6.1098
YH-13 GDSC2 3.8 7.7191 1.5079 10.1173
D-263MG GDSC2 3.8495 6.9631 1.9201 7.4464
A-172 GDSC2 3.9083 11.3323 -0.2057 19.2269
KALS-1 GDSC2 4.039 9.6406 0.7385 14.003
SW1783 GDSC2 4.15 7.2227 2.0111 6.1723
KS-1 [Human Krukenberg tumour] GDSC2 4.1934 6.8694 2.2114 4.8634
SF268 GDSC2 4.2599 8.0785 1.6728 7.9764
AM-38 GDSC2 4.3484 8.9081 1.3312 9.811
LNZTA3WT4 GDSC2 4.3603 9.2223 1.186 10.6342
DK-MG GDSC2 4.3789 5.9665 2.742 1.5102
GI-1 GDSC2 4.4994 10.1053 0.8545 12.1915
KINGS-1 GDSC2 4.6089 9.3904 1.2818 9.4971
Becker GDSC2 4.7111 6.656 2.6207 1.68
U-87MG ATCC GDSC2 4.737 8.446 1.8214 6.0679
MOG-G-CCM GDSC2 4.7635 8.6904 1.7231 6.5886
CAS-1 GDSC2 4.8301 7.764 2.1963 3.7504
D-392MG GDSC2 4.8542 10.321 1.0025 10.5388
U-118MG GDSC2 4.8939 7.0741 2.5373 1.8575
Daoy GDSC2 4.8946 8.5819 1.8585 5.5494
SK-MG-1 GDSC2 4.9013 10.3092 1.0409 10.2196
LN-405 GDSC2 5.1858 7.2344 2.6146 1.1885
DBTRG-05MG GDSC2 5.4125 12.2384 0.4627 12.2148
GB-1 GDSC2 5.5078 7.3884 2.696 0.6433
LN-229 GDSC2 5.5117 13.197 0.0688 13.9643
T98G GDSC2 5.608 11.8435 0.7826 10.1422
U-251MG GDSC2 5.6395 11.9397 0.7577 10.2104
SW1088 GDSC2 5.8461 14.0301 -0.1026 14.0641
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 2.8266 4.9275 2.0764 9.4543
TGBC1TKB GDSC2 4.5885 7.466 2.1863 4.2318
TGBC24TKB GDSC2 5.561 7.9629 2.4959 1.3305
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 1.9927 4.3259 1.5123 16.0165
EN GDSC2 4.1238 7.6875 1.766 7.7295
KLE GDSC2 4.2336 8.3462 1.5231 8.9406
MFE-319 GDSC2 4.6369 11.9205 0.0632 16.0212
MFE-280 GDSC2 4.998 7.5776 2.3752 2.5327
RL95-2 GDSC2 5.3369 7.1304 2.7223 0.6661
MFE-296 GDSC2 5.7098 10.998 1.2443 7.4752
AN3-CA GDSC2 5.9358 8.0079 2.6392 0.5742
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MV4-11 GDSC2 -0.5464 3.9666 -1.0918 40.7037
EoL-1 GDSC2 0.0242 3.6807 -0.381 34.9481
MOLT-16 GDSC2 0.7791 1.8696 0.7732 25.5473
SUP-M2 GDSC2 0.9209 2.6196 0.8546 24.4341
JVM-3 GDSC2 0.9539 2.8388 0.8517 24.2898
Ramos.2G6.4C10 GDSC2 0.9576 2.133 0.9449 23.7906
697 GDSC2 0.9968 3.3417 0.779 24.4728
SR GDSC2 1.0269 3.0253 0.8916 23.7326
HC-1 GDSC2 1.0411 3.019 0.9085 23.5762
RPMI-8866 GDSC2 1.0592 2.1709 1.0478 22.7646
GR-ST GDSC2 1.0617 3.5318 0.795 24.0872
DEL GDSC2 1.0745 4.5749 0.4415 25.9172
BV-173 GDSC2 1.1211 2.3867 1.0964 22.2105
A4/Fukuda GDSC2 1.1342 2.9106 1.0328 22.4785
RS4;11 GDSC2 1.1566 3.1444 1.0049 22.5206
GA-10 GDSC2 1.179 5.047 0.3604 25.8789
KOPN-8 GDSC2 1.1821 2.5619 1.1418 21.679
WIL2 NS GDSC2 1.2033 4.0264 0.7853 23.4993
WSU-DLCL2 GDSC2 1.2597 3.9691 0.8665 22.804
A3/Kawakami GDSC2 1.3002 2.5836 1.2647 20.469
MOLT-4 GDSC2 1.3171 3.6188 1.0462 21.5601
SU-DHL-6 GDSC2 1.3916 2.7072 1.3458 19.605
MOLP-8 GDSC2 1.4303 2.9148 1.3527 19.3831
NALM-6 GDSC2 1.467 5.2365 0.5786 23.4909
MOLM-13 GDSC2 1.4733 2.9143 1.3993 18.9331
EB2 GDSC2 1.5155 4.3747 0.9886 21.0124
CTV-1 GDSC2 1.5568 4.7182 0.8928 21.3774
JVM-2 GDSC2 1.5741 4.7296 0.9061 21.2303
Namalwa GDSC2 1.5846 3.2604 1.4424 18.1809
BC-1 GDSC2 1.6105 4.4314 1.0667 20.1689
WSU-NHL GDSC2 1.6299 3.6765 1.3676 18.3868
SCC-3 GDSC2 1.6451 4.5924 1.0375 20.1902
MHH-PREB-1 GDSC2 1.6536 3.2933 1.509 17.5027
P12-Ichikawa GDSC2 1.6628 4.3014 1.174 19.3383
KE-37 GDSC2 1.7029 3.3341 1.5517 17.0439
NKM-1 GDSC2 1.745 5.9326 0.5476 22.5278
Karpas-422 GDSC2 1.7451 3.3078 1.6049 16.5614
RPMI-8402 GDSC2 1.7526 3.7926 1.461 17.3251
SUP-T1 GDSC2 1.7795 4.0739 1.3868 17.6295
NCI-H929 GDSC2 1.8085 4.0019 1.4451 17.1734
Karpas-1106P GDSC2 1.9087 3.5987 1.6961 15.322
Mono-Mac-6 GDSC2 1.9155 4.3271 1.4308 16.8075
BL-41 GDSC2 1.9314 3.6187 1.7141 15.1208
OCI-AML-2 GDSC2 1.9378 3.8985 1.6224 15.6109
ARH-77 GDSC2 1.947 4.038 1.5793 15.8184
IM-9 GDSC2 1.9553 4.6743 1.326 17.2567
LC4-1 GDSC2 1.9703 5.3484 1.041 18.8639
VAL GDSC2 1.9827 4.5811 1.3945 16.746
VL51 GDSC2 1.9838 4.7477 1.3235 17.1576
Jiyoye GDSC2 2.0098 5.5014 1.0102 18.8906
DG-75 GDSC2 2.0393 4.0494 1.6731 14.8907
ML-2 GDSC2 2.0467 3.5336 1.8672 13.7573
DND-41 GDSC2 2.0549 4.1817 1.6369 15.0356
RPMI-6666 GDSC2 2.0705 3.6699 1.8476 13.7619
L-363 GDSC2 2.0822 3.5624 1.8964 13.4373
CA46 GDSC2 2.2626 4.0492 1.9096 12.5925
JSC-1 GDSC2 2.2633 4.0457 1.9118 12.5767
OCI-AML-5 GDSC2 2.28 3.9841 1.9543 12.2605
Ku812 GDSC2 2.2914 6.1227 0.9914 17.9493
KMS-12-BM GDSC2 2.3048 5.0506 1.5118 14.7969
DB GDSC2 2.3395 4.2673 1.8987 12.3451
RC-K8 GDSC2 2.3423 6.3609 0.9248 18.1535
U-698-M GDSC2 2.3449 7.5094 0.367 21.2477
ST486 GDSC2 2.3472 4.4298 1.8358 12.6889
JURL-MK1 GDSC2 2.3478 4.0776 1.9875 11.7882
BALL-1 GDSC2 2.4002 4.7606 1.7405 13.0575
L-1236 GDSC2 2.4157 4.4979 1.8754 12.186
ATN-1 GDSC2 2.4342 3.7763 2.1999 10.196
BE-13 GDSC2 2.4412 5.1198 1.614 13.6728
SU-DHL-5 GDSC2 2.474 3.7713 2.2442 9.7735
CML-T1 GDSC2 2.5519 3.5431 2.4123 8.482
SU-DHL-10 GDSC2 2.5546 3.9491 2.2575 9.3643
Raji GDSC2 2.581 4.6558 1.9686 10.997
KCL-22 GDSC2 2.6074 4.9118 1.8743 11.4775
MLMA GDSC2 2.6121 5.0987 1.7897 11.9801
ALL-SIL GDSC2 2.6321 6.0572 1.3441 14.6431
Loucy GDSC2 2.6628 6.1754 1.3145 14.7179
OCI-M1 GDSC2 2.7798 5.3297 1.8369 11.1039
RPMI-8226 GDSC2 2.7805 5.3377 1.8336 11.1213
GDM-1 GDSC2 2.8178 5.9858 1.5496 12.7582
KY821 GDSC2 2.8991 4.1639 2.5119 6.5065
Daudi GDSC2 2.9198 5.0798 2.0889 9.0598
ALL-PO GDSC2 2.9389 5.5335 1.8827 10.2872
CESS GDSC2 2.9408 4.191 2.5398 6.1843
CCRF-CEM GDSC2 2.9982 6.526 1.4427 12.8344
P32/ISH GDSC2 3.0611 5.0863 2.2139 7.812
SUP-B15 GDSC2 3.0848 4.3383 2.6047 5.2808
OCI-AML-3 GDSC2 3.1517 5.4766 2.0996 8.2474
OPM-2 GDSC2 3.1566 5.1874 2.2481 7.2949
LAMA-84 GDSC2 3.1796 4.9839 2.3696 6.4568
H9 GDSC2 3.189 6.1896 1.7759 10.1718
P31/FUJ GDSC2 3.1903 9.5967 0.0742 19.9617
MEG-01 GDSC2 3.3073 8.5914 0.675 16.4196
Karpas-45 GDSC2 3.3251 4.9568 2.5071 5.1496
Hs 445 GDSC2 3.3673 4.7846 2.6281 4.263
TUR GDSC2 3.4143 8.7085 0.7053 15.9313
MOLT-13 GDSC2 3.4308 7.8869 1.1295 13.4264
SK-MM-2 GDSC2 3.5415 5.5615 2.3794 5.3588
PF-382 GDSC2 3.5499 7.7236 1.3081 12.0141
P30/OHK GDSC2 3.5578 5.0143 2.6634 3.5318
Reh GDSC2 3.5672 7.1326 1.6169 10.0729
KMOE-2 GDSC2 3.5806 6.1202 2.132 6.813
L-428 GDSC2 3.6366 7.0108 1.7327 9.1646
KM-H2 GDSC2 3.6753 6.2843 2.1239 6.6158
L-540 GDSC2 3.6968 6.9624 1.8039 8.561
NOMO-1 GDSC2 3.8536 6.6795 2.063 6.5487
HH [Human lymphoma] GDSC2 3.886 6.4931 2.1783 5.7548
HAL-01 GDSC2 3.9506 9.0124 0.9822 12.8527
MM1.S GDSC2 3.9561 8.8158 1.084 12.2464
SUP-HD1 GDSC2 4.0535 6.4789 2.3037 4.6044
Karpas-299 GDSC2 4.0762 6.4911 2.3134 4.4964
Granta-519 GDSC2 4.0934 6.4408 2.3492 4.2437
MHH-CALL-2 GDSC2 4.1395 7.6221 1.8093 7.4284
ME1 GDSC2 4.1793 6.1473 2.5438 2.9208
K-562 GDSC2 4.2496 6.5402 2.4046 3.5997
EM-2 GDSC2 4.3992 6.4281 2.5482 2.5123
SU-DHL-8 GDSC2 4.4536 6.8954 2.3671 3.4386
MN-60 GDSC2 4.4541 6.3438 2.6176 2.0498
HDLM-2 GDSC2 4.4563 7.6992 1.9912 5.634
YT GDSC2 4.5108 9.8111 1.0069 11.3053
EJM GDSC2 4.6216 7.0937 2.3775 3.0913
JJN-3 GDSC2 4.7745 9.1156 1.5279 7.7038
Karpas-620 GDSC2 4.8754 9.5485 1.3888 8.2971
U266B1 GDSC2 4.9568 7.1619 2.5324 1.8034
TK [Human B-cell lymphoma] GDSC2 5.0005 6.5563 2.7988 0.6345
KG-1 GDSC2 5.4818 7.8702 2.4964 1.4015
Karpas-231 GDSC2 5.6456 7.1352 2.8411 0.2174
Jurkat GDSC2 5.7995 7.3881 2.8091 0.232
HL-60 GDSC2 5.8677 6.9495 2.9793 0.028
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACHN GDSC2 2.7007 5.5908 1.6357 12.6199
769-P GDSC2 3.382 8.29 0.8878 14.9873
786-O GDSC2 3.398 9.1043 0.4939 17.146
KTCTL-195 GDSC2 3.7107 7.3811 1.6065 9.7482
TK-10 GDSC2 3.9909 7.3777 1.821 7.7108
SW13 GDSC2 4.0479 6.7974 2.1457 5.5802
RCC10RGB GDSC2 4.1237 8.1952 1.5169 9.2424
BFTC-909 GDSC2 4.221 6.2909 2.5031 3.0793
A-498 GDSC2 4.5329 11.2402 0.3211 14.9787
A-704 GDSC2 4.5922 13.5885 -0.795 20.0378
OS-RC-2 GDSC2 4.7663 7.1182 2.4494 2.4773
LB996-RCC GDSC2 5.0652 9.8542 1.3694 8.0164
CAL-54 GDSC2 5.2151 11.9203 0.48 12.5553
KMRC-1 GDSC2 5.2778 9.0072 1.8965 4.6609
VMRC-RCZ GDSC2 5.4204 7.1619 2.7449 0.5443
KMRC-20 GDSC2 5.6181 12.822 0.3224 12.4891
SN12C GDSC2 5.7843 7.3817 2.8058 0.2426
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC2 1.4892 4.3704 0.9624 21.272
LoVo GDSC2 2.0789 5.8282 0.926 19.1151
HT-29 GDSC2 2.3285 5.7485 1.2063 16.5449
RKO GDSC2 2.4986 5.5592 1.4602 14.402
HCT 116 GDSC2 2.9516 8.0502 0.6425 17.7034
MDST8 GDSC2 2.9544 6.9236 1.2063 14.4142
KM12 GDSC2 3.0409 5.2373 2.1211 8.4611
SW48 GDSC2 3.1361 6.3114 1.6696 10.9978
LS123 GDSC2 3.1785 8.0773 0.8237 15.9675
SNU-C5 GDSC2 3.2204 8.8041 0.4958 17.6702
LS513 GDSC2 3.319 6.3172 1.8219 9.4965
LS411N GDSC2 3.376 5.3815 2.3369 6.0813
RCM-1 [Human ESC] GDSC2 3.4967 7.5515 1.3509 11.9047
GP5d GDSC2 3.5328 8.3325 0.9901 13.9554
HT-55 GDSC2 3.5947 5.18 2.6093 3.7786
SK-CO-1 GDSC2 3.6002 8.7572 0.8325 14.6732
HCT 15 GDSC2 3.8328 8.0499 1.369 10.8753
LS1034 GDSC2 3.8608 10.8274 0.0082 18.3276
COLO205 GDSC2 3.8645 6.5245 2.1473 5.9987
SNU-407 GDSC2 3.9095 6.3541 2.2633 5.1743
LS180 GDSC2 4.0658 5.9543 2.562 3.0297
SW620 GDSC2 4.1015 8.036 1.5788 8.9223
SW1463 GDSC2 4.1082 10.0029 0.612 14.5189
SNU-61 GDSC2 4.2249 7.3789 1.9877 6.1478
COLO 320HSR GDSC2 4.3185 6.1466 2.6283 2.2023
NCI-H747 GDSC2 4.391 7.6809 1.9561 5.9793
CCK-81 GDSC2 4.3948 8.3368 1.6426 7.8508
SW948 GDSC2 4.4583 10.3421 0.708 13.1032
HCC2998 GDSC2 4.4686 13.3998 -0.7962 20.3565
SW1116 GDSC2 4.5531 8.4072 1.7177 7.0563
NCI-H716 GDSC2 4.5848 9.0838 1.4135 8.783
CW-2 GDSC2 4.6126 9.2945 1.3309 9.2034
SNU-C2B GDSC2 4.6499 10.2211 0.9067 11.5418
SNU-C1 GDSC2 4.6885 8.4751 1.7759 6.4313
SW837 GDSC2 4.8358 8.3082 1.9492 5.1392
SW1417 GDSC2 5.053 9.5626 1.4994 7.3012
T84 GDSC2 5.0935 9.2455 1.6742 6.2284
SW626 GDSC2 5.2022 7.18 2.6439 1.0545
CL-11 GDSC2 5.2508 7.5978 2.4972 1.6307
COLO 678 GDSC2 5.54 7.4173 2.6984 0.6166
C2BBe1 GDSC2 5.5429 17.0749 -1.8028 21.6049
CaR-1 GDSC2 5.6603 7.6173 2.6729 0.6249
DiFi GDSC2 6.2699 8.8465 2.4626 0.9158
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 2.8182 5.4482 1.8145 11.1132
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC2 2.2498 5.6374 1.1828 16.9725
JHH-6 GDSC2 3.5177 5.504 2.3895 5.3584
SNU-387 GDSC2 3.9874 6.9688 2.019 6.499
Hep-G2/C3A GDSC2 4.0345 5.9154 2.5601 3.1024
SNU-449 GDSC2 4.2664 11.2794 0.1003 16.7789
JHH-1 GDSC2 4.3637 14.5128 -1.4308 23.1046
SNU-423 GDSC2 4.5439 7.9587 1.9258 5.8427
HuH-1 GDSC2 4.6978 6.2355 2.7895 0.9204
JHH-4 GDSC2 4.8831 9.4687 1.4321 8.0317
Huh-7 GDSC2 4.9605 11.4643 0.5223 12.9075
HLE GDSC2 5.082 8.5394 1.9931 4.4557
SK-HEP-1 GDSC2 5.4236 12.6805 0.2573 13.2306
JHH-7 GDSC2 6.2543 7.721 2.8551 0.0823
JHH-2 GDSC2 6.9784 16.4836 -0.5181 13.6868
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 131 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H446 GDSC2 1.5035 5.5959 0.4576 23.9895
NCI-H847 GDSC2 1.5882 3.9482 1.2282 19.3497
NCI-H211 GDSC2 1.8167 3.5379 1.6155 16.1794
SBC-3 GDSC2 1.8619 5.5448 0.8426 20.427
COR-L279 GDSC2 1.9414 3.4213 1.787 14.6728
Lu-135 GDSC2 1.9806 3.6667 1.7513 14.6962
Lu-65 GDSC2 2.0168 3.6005 1.8128 14.193
NCI-H524 GDSC2 2.0907 4.2862 1.6315 14.9203
Lu-139 GDSC2 2.0951 3.4944 1.9323 13.1802
HARA [Human squamous cell lung carcinoma] GDSC2 2.1357 4.9148 1.4043 16.0844
COR-L88 GDSC2 2.1932 4.1006 1.8156 13.4255
COR-L95 GDSC2 2.2682 4.0392 1.9196 12.5107
NCI-H1975 GDSC2 2.2954 6.4119 0.8558 18.7205
Ms-1 GDSC2 2.2959 3.8732 2.015 11.843
NCI-H2122 GDSC2 2.3219 4.1999 1.9092 12.3532
NCI-H82 GDSC2 2.3414 3.7813 2.0988 11.1686
CPC-N GDSC2 2.3541 3.7952 2.1071 11.0677
NCI-H64 GDSC2 2.5894 3.5464 2.4517 8.0962
NCI-H1703 GDSC2 2.6629 6.9748 0.9209 17.062
NCI-H1688 GDSC2 2.7764 4.3813 2.2895 8.3176
NCI-H1993 GDSC2 2.8235 5.1186 1.9806 10.0605
NCI-H810 GDSC2 2.8402 5.8408 1.6415 12.1148
Lu-165 GDSC2 2.8808 4.2761 2.4411 7.0072
NCI-H322M GDSC2 2.8962 8.3361 0.4518 18.9273
NCI-H520 GDSC2 2.9394 6.0629 1.6209 11.9193
NCI-H2170 GDSC2 3.0009 7.6033 0.9082 16.0328
NCI-H69 GDSC2 3.0546 6.2896 1.6099 11.6226
HCC44 GDSC2 3.1275 5.5543 2.0398 8.6997
LCLC-97TM1 GDSC2 3.1486 9.3502 0.1622 19.6469
RERF-LC-Sq1 GDSC2 3.294 5.9038 2.0076 8.4001
NCI-H209 GDSC2 3.338 6.973 1.5098 11.3873
NCI-H2731 GDSC2 3.3955 7.2479 1.4199 11.7732
NCI-H1666 GDSC2 3.5173 6.316 1.9844 7.9127
COR-L311 GDSC2 3.529 6.1547 2.0742 7.3155
NCI-H2009 GDSC2 3.5381 5.6686 2.3235 5.7199
HCC827 GDSC2 3.5399 6.4757 1.9228 8.238
EMC-BAC-2 GDSC2 3.5453 7.2868 1.5224 10.7178
NCI-H1963 GDSC2 3.5475 7.1006 1.6171 10.1259
NCI-H2795 GDSC2 3.5476 7.3607 1.4874 10.9266
COR-L23 GDSC2 3.5549 8.3329 1.0079 13.7886
EPLC-272H GDSC2 3.5919 7.3759 1.5153 10.6327
A-549 GDSC2 3.6193 7.1094 1.6699 9.6014
NCI-H1299 GDSC2 3.6343 6.4204 2.0247 7.345
PC-14 GDSC2 3.8118 7.6135 1.5695 9.7092
HOP-62 GDSC2 3.8426 7.7579 1.5215 9.9226
NCI-H358 GDSC2 3.8466 10.3477 0.2362 17.2197
LOU-NH91 GDSC2 3.9103 5.9284 2.4705 3.9012
NCI-H2023 GDSC2 3.9279 8.3568 1.2899 11.1015
Calu-6 GDSC2 3.9752 6.9978 1.9959 6.6706
SHP-77 GDSC2 4.007 7.0914 1.9732 6.7352
NCI-H2461 GDSC2 4.0083 9.2907 0.8885 13.2381
DMS 273 GDSC2 4.009 8.5475 1.2573 11.0867
NCI-H720 GDSC2 4.0229 5.725 2.6423 2.6409
NCI-H1648 GDSC2 4.0232 8.9819 1.053 12.2518
NCI-H1915 GDSC2 4.0449 7.9195 1.5943 8.9664
SBC-5 GDSC2 4.0568 8.6613 1.2372 11.0838
COR-L105 GDSC2 4.0621 6.7746 2.1667 5.4199
HCC78 GDSC2 4.1057 8.5333 1.3371 10.3666
NCI-H596 GDSC2 4.1063 9.2798 0.9688 12.5238
NCI-H2228 GDSC2 4.1138 11.4538 -0.1044 18.1848
SK-LU-1 GDSC2 4.1336 7.6098 1.811 7.4314
NCI-H2066 GDSC2 4.1404 10.3299 0.4745 15.1766
NCI-H1781 GDSC2 4.1752 7.5268 1.8812 6.9072
EBC-1 GDSC2 4.1826 6.6965 2.2868 4.4326
NCI-H2818 GDSC2 4.1834 7.0971 2.0951 5.5874
SW1271 GDSC2 4.2204 8.5131 1.4317 9.5198
NCI-H1563 GDSC2 4.2609 7.0146 2.1874 4.8663
NCI-H526 GDSC2 4.287 5.8409 2.7467 1.6146
NCI-H1755 GDSC2 4.2899 10.294 0.6061 14.0808
NCI-H1651 GDSC2 4.2904 13.6477 -1.0577 21.8789
COLO 668 GDSC2 4.2909 10.2606 0.6233 13.9848
NCI-H3122 GDSC2 4.335 8.7606 1.3937 9.4727
NCI-H1623 GDSC2 4.3776 7.5701 2.0001 5.7443
NCI-H513 GDSC2 4.4333 10.8626 0.4329 14.6445
NCI-H727 GDSC2 4.441 12.4671 -0.3548 18.4997
NCI-H2369 GDSC2 4.4956 7.4325 2.1431 4.6583
LK-2 GDSC2 4.5397 13.0513 -0.5689 19.2043
NCI-H661 GDSC2 4.5459 6.9072 2.4174 2.9952
NCI-H441 GDSC2 4.5529 9.3431 1.2653 9.7204
NCI-H2373 GDSC2 4.5739 10.0275 0.9467 11.4965
NCI-H522 GDSC2 4.575 6.912 2.4324 2.8642
SK-MES-1 GDSC2 4.5813 7.566 2.1352 4.5409
Lu-99A GDSC2 4.5958 8.4075 1.7464 6.7966
NCI-H1693 GDSC2 4.5979 8.025 1.9298 5.7097
NCI-H1435 GDSC2 4.6363 9.9818 1.0137 10.9721
NCI-H1793 GDSC2 4.7013 7.6848 2.1548 4.2076
NCI-H1944 GDSC2 4.7039 8.8864 1.5901 7.4892
NCI-H2087 GDSC2 4.7192 7.7152 2.1518 4.1927
NCI-H2591 GDSC2 4.7469 9.0091 1.5603 7.5728
NCI-H1573 GDSC2 4.7511 7.3189 2.3514 3.0255
NCI-H1155 GDSC2 4.7669 8.2861 1.9159 5.4603
NCI-H23 GDSC2 4.8124 10.8197 0.7309 12.1333
NCI-H226 GDSC2 4.8968 9.003 1.6622 6.6758
NCI-H2085 GDSC2 4.9176 12.0541 0.2036 14.6453
NCI-H1581 GDSC2 4.9221 8.5723 1.8803 5.3736
PaCa-3 GDSC2 4.9656 7.4954 2.3934 2.4839
NCI-H1092 GDSC2 5.0082 7.2487 2.522 1.7914
NCI-H1869 GDSC2 5.0185 8.3746 2.0304 4.3558
LXF 289 GDSC2 5.0247 10.4047 1.0795 9.7356
NCI-H1048 GDSC2 5.0318 8.1753 2.1287 3.7919
NCI-H2347 GDSC2 5.077 11.2043 0.7302 11.5391
IA-LM GDSC2 5.0773 6.3401 2.9101 0.2658
LC-1/sq GDSC2 5.1067 7.9059 2.2909 2.8143
SW1573 GDSC2 5.1157 8.4038 2.0745 3.9525
NCI-H1792 GDSC2 5.1495 13.2671 -0.222 16.1577
DMS 114 GDSC2 5.1861 10.5557 1.1158 9.1945
NCI-H1838 GDSC2 5.1963 6.9404 2.7352 0.7177
NCI-H1650 GDSC2 5.2051 7.6639 2.4468 1.914
RERF-LC-KJ GDSC2 5.3284 11.5611 0.7307 10.9928
NCI-H196 GDSC2 5.3819 7.0422 2.7738 0.4809
NCI-H2722 GDSC2 5.395 12.4308 0.358 12.7867
HCC15 GDSC2 5.4257 10.4196 1.3356 7.5014
NCI-H2141 GDSC2 5.457 10.1897 1.4623 6.7436
NCI-H1694 GDSC2 5.4749 7.2501 2.7343 0.5456
KNS-62 GDSC2 5.5073 15.3917 -1.0028 18.7112
NCI-H1355 GDSC2 5.5174 13.9939 -0.3135 15.7437
VMRC-LCD GDSC2 5.5268 8.516 2.2506 2.462
NCI-H1341 GDSC2 5.5352 7.1618 2.7904 0.3647
UMC-11 GDSC2 5.5378 7.4141 2.6987 0.617
NCI-H841 GDSC2 5.5409 13.7741 -0.1903 15.1269
DMS 53 GDSC2 5.5467 10.4687 1.3885 6.9865
NCI-H2342 GDSC2 5.5584 7.9404 2.5037 1.3011
NCI-H835 GDSC2 5.5662 9.4963 1.8437 4.4838
Calu-3 GDSC2 5.5703 9.0685 2.0354 3.4757
NCI-H650 GDSC2 5.5764 8.1034 2.4465 1.5203
NCI-H1568 GDSC2 5.657 13.8725 -0.1568 14.7187
LCLC-103H GDSC2 5.7146 14.0086 -0.1827 14.7149
NCI-H2595 GDSC2 5.8068 13.1718 0.2822 12.2972
HOP-92 GDSC2 5.9037 8.9764 2.2463 2.0551
NCI-H1876 GDSC2 6.0122 7.6121 2.8082 0.1794
NCI-H2405 GDSC2 6.2001 8.002 2.7413 0.2425
⏷ Show the Full List of 131 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 1.7937 3.6995 1.5376 16.715
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC2 2.5399 4.9025 1.8127 12.0997
KYSE-150 GDSC2 2.8254 5.6652 1.7145 11.7109
COLO 680N GDSC2 2.9995 4.6451 2.3756 6.9998
KYSE-140 GDSC2 3.642 6.9958 1.7445 9.0767
KYSE-180 GDSC2 3.6537 7.6951 1.4053 11.1363
OE21 GDSC2 3.7457 6.4092 2.1157 6.4879
OE33 GDSC2 3.9735 12.294 -0.6334 20.9761
TE-5 GDSC2 3.9789 9.0709 0.9749 12.8197
KYSE-450 GDSC2 4.0044 10.018 0.5243 15.2703
KYSE-270 GDSC2 4.0367 9.5398 0.7868 13.7386
TE-6 GDSC2 4.28 7.6144 1.9122 6.4836
KYSE-410 GDSC2 4.305 7.9126 1.7852 7.195
TE-15 GDSC2 4.3753 8.5943 1.5037 8.7248
TE-8 GDSC2 4.6643 8.6206 1.6905 6.9827
KYSE-520 GDSC2 4.6882 9.0741 1.4895 8.1114
EC-GI-10 GDSC2 4.748 8.0951 1.9933 5.0491
TE-4 GDSC2 4.9567 9.1074 1.6517 6.6185
KYSE-70 GDSC2 5.312 12.3142 0.3569 12.9735
T.T GDSC2 5.3976 8.2678 2.2896 2.4336
TE-1 GDSC2 5.6302 10.166 1.5785 5.8049
TE-9 GDSC2 6.1921 15.1679 -0.4135 14.7591
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 1.6993 6.2449 0.3575 23.7238
OC 314 GDSC2 2.4434 8.5178 -0.0402 22.9688
OVCAR-5 GDSC2 2.8248 8.3134 0.4007 19.4339
DOV13 GDSC2 3.1259 9.7117 -0.0377 20.7145
OVTOKO GDSC2 3.4932 7.7022 1.2729 12.3876
ES-2 GDSC2 3.5506 5.263 2.5348 4.3573
OV56 GDSC2 3.6172 5.316 2.559 4.0369
SK-OV-3 GDSC2 4.0946 8.6259 1.2831 10.7156
OAW42 GDSC2 4.0996 5.9301 2.595 2.772
IGROV-1 GDSC2 4.1662 10.9563 0.1835 16.6232
FU-OV-1 GDSC2 4.1949 8.1973 1.568 8.7625
Kuramochi GDSC2 4.3124 7.2174 2.125 5.1332
TOV-21G GDSC2 4.3386 11.4605 0.0658 16.7623
OVISE GDSC2 4.3787 9.4225 1.1013 11.0813
TYK-nu GDSC2 4.5506 10.1365 0.8765 11.9457
OV-90 GDSC2 4.765 18.5448 -3.1229 27.3391
OVKATE GDSC2 4.8606 7.2488 2.444 2.3704
Caov-4 GDSC2 4.9019 10.3984 0.9982 10.457
TOV-112D GDSC2 5.0214 7.8617 2.263 3.0843
OVCAR-4 GDSC2 5.0482 8.8309 1.8387 5.3799
RMG-I GDSC2 5.1581 12.397 0.2087 14.0634
EFO-21 GDSC2 5.2476 11.0217 0.9345 10.0646
OVCAR-3 GDSC2 5.397 7.1333 2.7461 0.5541
OAW28 GDSC2 5.905 8.7279 2.3481 1.6196
OVCAR-8 GDSC2 7.2805 18.8376 -1.4365 16.7628
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DAN-G GDSC2 2.7108 3.9657 2.4125 7.8228
PL4 GDSC2 3.5227 8.4973 0.8996 14.5099
KP-1N GDSC2 3.6699 8.6312 0.9515 13.7929
Panc 02.03 GDSC2 3.6812 12.3924 -0.9174 22.9759
PaTu 8902 GDSC2 3.8589 5.9823 2.4083 4.3975
KP-4 GDSC2 3.9043 8.1798 1.3596 10.7446
PaTu 8988t GDSC2 3.983 7.8753 1.5699 9.2688
SU.86.86 GDSC2 4.0145 8.9686 1.053 12.2746
CFPAC-1 GDSC2 4.0217 7.8916 1.5909 9.0446
HuP-T3 GDSC2 4.1085 9.3918 0.915 12.8258
Panc 04.03 GDSC2 4.1153 6.7895 2.1965 5.1209
YAPC GDSC2 4.1262 8.9024 1.1703 11.3026
Capan-2 GDSC2 4.2162 7.2349 2.0513 5.7818
Panc 10.05 GDSC2 4.2845 7.505 1.9681 6.1361
BxPC-3 GDSC2 4.4192 11.013 0.3482 15.1232
Hs 766T GDSC2 4.4996 9.3167 1.2403 9.9888
KP-3 GDSC2 4.5914 8.2201 1.8329 6.2946
SW1990 GDSC2 4.8948 9.1653 1.5842 7.1304
HPAC GDSC2 4.9081 8.8406 1.746 6.1705
AsPC-1 GDSC2 4.9843 8.348 2.022 4.4607
Panc 08.13 GDSC2 5.0266 12.4086 0.1091 14.8597
HuP-T4 GDSC2 5.1251 12.9612 -0.0901 15.5947
HPAF-II GDSC2 5.3741 11.6072 0.7395 10.8499
Capan-1 GDSC2 5.4568 7.2846 2.7139 0.6179
KP-2 GDSC2 5.5175 6.9143 2.8713 0.1987
Panc 03.27 GDSC2 5.7042 8.2411 2.4505 1.3853
MIA PaCa-2 GDSC2 5.745 7.317 2.814 0.2389
PSN1 GDSC2 5.7653 8.0689 2.5454 0.9764
SUIT-2 GDSC2 6.18 16.075 -0.8584 16.6748
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC2 3.99 5.9684 2.5055 3.519
MPP 89 GDSC2 4.0127 8.4349 1.3158 10.7286
NCI-H2052 GDSC2 4.166 7.8333 1.7251 7.8789
NCI-H28 GDSC2 4.2465 9.6381 0.8974 12.574
MSTO-211H GDSC2 4.8294 10.9034 0.7022 12.2496
NCI-H2452 GDSC2 5.8572 15.3609 -0.7379 16.8557
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC2 2.1263 3.777 1.8696 13.3958
LNCaP clone FGC GDSC2 3.0904 6.9321 1.3205 13.2947
VCaP GDSC2 3.9217 13.0749 -1.0642 22.8901
PC-3 GDSC2 5.5814 8.5407 2.2681 2.3134
DU145 GDSC2 6.6186 8.6024 2.6845 0.2321
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 4.7592 9.2775 1.4401 8.247
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LOX-IMVI GDSC2 1.2278 3.8443 0.8752 22.8982
WM793 GDSC2 2.148 4.5648 1.5722 15.0399
HMV-II GDSC2 2.3312 4.2971 1.8773 12.5052
IST-MEL1 GDSC2 2.464 4.9116 1.734 12.8589
SH-4 GDSC2 3.1512 6.743 1.4671 12.2085
COLO 679 GDSC2 3.7182 9.6447 0.4844 16.2719
WM1552C GDSC2 3.8822 8.1164 1.3741 10.7146
GAK GDSC2 3.9859 11.6677 -0.3113 19.5058
A2058 GDSC2 4.0515 9.1061 1.0131 12.41
M14 GDSC2 4.0897 7.0438 2.0555 6.0377
A-375 GDSC2 4.109 7.8096 1.6954 8.1949
COLO 792 GDSC2 4.1872 6.5322 2.368 3.9385
RPMI-7951 GDSC2 4.2904 7.7015 1.8773 6.6712
WT2-iPS GDSC2 4.2929 7.6867 1.8862 6.612
SK-MEL-24 GDSC2 4.3271 8.1462 1.6875 7.7342
COLO 829 GDSC2 4.4484 8.342 1.6774 7.5235
A101D GDSC2 4.7068 10.242 0.9371 11.2395
SK-MEL-2 GDSC2 4.7367 13.0719 -0.4301 18.0964
IGR-37 GDSC2 4.7861 7.4348 2.3196 3.1432
WM35 GDSC2 4.7919 7.5803 2.2572 3.4763
WM115 GDSC2 4.9665 8.2734 2.0454 4.3605
IGR-1 GDSC2 4.9797 8.4055 1.9929 4.6322
SK-MEL-1 GDSC2 5.007 6.4675 2.8353 0.5088
G-361 GDSC2 5.2279 6.769 2.813 0.4501
Mel JuSo GDSC2 5.2618 6.5242 2.914 0.1937
HT-144 GDSC2 5.2843 8.4254 2.1605 3.237
UACC-257 GDSC2 5.3062 14.331 -0.6292 17.6166
UACC-62 GDSC2 5.3476 11.4908 0.7774 10.7034
WM278 GDSC2 5.7633 10.954 1.2976 7.0921
CHL-1 GDSC2 5.806 14.8662 -0.5339 16.094
MeWo GDSC2 6.4623 14.3769 0.1412 11.691
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC2 1.389 7.1782 -0.3845 28.5405
Rh41 GDSC2 2.3633 4.7465 1.7099 13.3821
KYM-1 GDSC2 2.613 6.2794 1.2176 15.4735
Hs 633.T GDSC2 3.0027 5.8488 1.7835 10.7029
G-402 GDSC2 3.1143 9.828 -0.1057 21.0803
Rh30 GDSC2 3.2285 5.422 2.193 7.4234
MES-SA GDSC2 3.2381 5.7165 2.0541 8.2723
SW684 GDSC2 3.8192 9.6759 0.5492 15.6393
A-204 GDSC2 3.8776 7.7012 1.5764 9.4965
SW982 GDSC2 4.0353 8.682 1.2107 11.2956
GCT GDSC2 4.1321 6.6836 2.259 4.7062
SW872 GDSC2 4.3302 6.7314 2.3663 3.6696
EW-8 GDSC2 4.4133 7.4158 2.0975 5.0902
SK-LMS-1 GDSC2 4.7037 8.6449 1.7052 6.8152
HT-1080 GDSC2 5.1533 7.0045 2.6914 0.9107
MFH-ino GDSC2 5.4196 7.2175 2.7238 0.6094
RKN GDSC2 5.4513 12.8603 0.1896 13.506
VA-ES-BJ GDSC2 5.6371 7.3034 2.7786 0.3511
SK-UT-1 GDSC2 6.1574 10.4775 1.7394 4.1581
RD GDSC2 6.1788 13.3914 0.4225 10.8676
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 GDSC2 1.846 4.6884 1.2068 18.3918
ECC10 GDSC2 2.4806 4.0288 2.1468 10.314
MKN28 GDSC2 2.7738 6.4973 1.2572 14.6934
HSC-39 GDSC2 2.9381 11.0038 -0.8434 24.8962
SNU-1 GDSC2 3.3061 5.8866 2.0264 8.2461
IM95 GDSC2 3.3469 6.4 1.8037 9.5299
RERF-GC-1B GDSC2 3.3578 8.4839 0.7708 15.7286
MKN45 GDSC2 3.4726 6.284 1.9645 8.162
MKN1 GDSC2 3.6306 6.2033 2.1297 6.6959
SK-GT-2 GDSC2 3.7061 6.8996 1.8423 8.2974
23132/87 GDSC2 3.7948 9.0167 0.8584 13.9825
RF-48 GDSC2 3.8011 10.4392 0.1544 17.764
TGBC11TKB GDSC2 3.918 7.5214 1.6959 8.6609
NUGC-4 GDSC2 4.035 7.8201 1.636 8.7369
SNU-5 GDSC2 4.0697 6.9483 2.0878 5.8855
NCI-N87 GDSC2 4.0718 7.6474 1.7478 7.9639
NUGC-3 GDSC2 4.0795 8.2443 1.4601 9.6941
OCUM-1 GDSC2 4.2224 7.2714 2.0379 5.8491
KATO III GDSC2 4.3436 6.806 2.3399 3.7982
Fu97 GDSC2 4.479 10.928 0.4349 14.5199
HGC-27 GDSC2 4.5151 7.1685 2.2787 3.8342
AGS GDSC2 4.8844 7.5344 2.3312 2.9276
GCIY GDSC2 4.9253 13.5473 -0.5238 18.0532
Hs 746.T GDSC2 5.4853 7.338 2.7057 0.6267
SNG-M GDSC2 5.1086 10.3676 1.1538 9.1427
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 3.042 4.9253 2.2764 7.4809
IHH-4 GDSC2 3.2495 5.1547 2.3445 6.4027
B-CPAP GDSC2 3.6766 8.3187 1.1126 12.8311
TT GDSC2 3.8696 5.5323 2.6331 3.0023
CAL-62 GDSC2 3.9683 6.236 2.362 4.4353
FTC-133 GDSC2 4.2976 9.0634 1.2181 10.5978
BHT-101 GDSC2 4.6145 8.7059 1.6161 7.5259
WRO GDSC2 4.7834 7.1478 2.4459 2.4709
8305C GDSC2 4.7903 14.422 -1.0569 20.611
TT2609-C02 GDSC2 4.8148 9.6435 1.3021 8.9245
HTC-C3 GDSC2 5.148 8.0561 2.2477 2.9796
ASH-3 GDSC2 5.4197 7.0535 2.7847 0.4315
CGTH-W-1 GDSC2 5.5591 6.9786 2.8641 0.2
8505C GDSC2 5.7886 12.9601 0.3711 11.893
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC2 1.7653 4.0564 1.3782 17.7389
JHU-022 GDSC2 2.6267 7.6967 0.5312 19.3871
HO-1-u-1 GDSC2 3.2643 7.884 0.9927 14.7268
HO-1-N-1 GDSC2 3.3648 6.1366 1.9501 8.5572
Detroit 562 GDSC2 3.5517 9.8925 0.2261 18.1088
HSC-3 GDSC2 3.6804 7.687 1.4305 10.9098
SKN-3 GDSC2 3.7783 7.6747 1.5132 10.1422
BICR 10 GDSC2 3.8336 6.2582 2.2553 5.4023
UPCI-SCC-090 GDSC2 4.1094 6.6437 2.2626 4.7327
FaDu GDSC2 4.125 9.4447 0.9013 12.8611
CAL-27 GDSC2 4.3396 8.348 1.5982 8.2419
PCI-30 GDSC2 4.4352 9.069 1.3151 9.7015
BICR 22 GDSC2 4.5525 6.1139 2.7691 1.1622
Ca9-22 GDSC2 4.6742 7.0502 2.4276 2.7325
HSC-2 GDSC2 4.7329 9.0474 1.5325 7.7644
SAS GDSC2 4.7634 10.686 0.7611 12.082
SAT [Human HNSCC] GDSC2 5.0964 10.8911 0.8946 10.6046
CAL-33 GDSC2 5.2295 7.9231 2.3492 2.3543
LB771-HNC GDSC2 5.3023 7.6087 2.5177 1.4866
DOK GDSC2 5.3162 9.0289 1.9092 4.5283
OSC-20 GDSC2 5.4903 8.0006 2.4474 1.6009
SCC-15 GDSC2 5.5458 8.7285 2.1697 2.8323
HSC-4 GDSC2 5.6117 7.184 2.8115 0.287
BICR 78 GDSC2 5.6151 12.5962 0.4286 11.9609
SCC-4 GDSC2 5.7116 7.3778 2.7802 0.3189
SCC-9 GDSC2 5.7401 7.8178 2.6306 0.7083
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC2 2.777 6.4928 1.2622 14.6523
RT-112 GDSC2 3.3724 5.6123 2.2185 6.8401
BFTC-905 GDSC2 3.6041 9.3637 0.5329 16.3328
CAL-29 GDSC2 3.7933 7.2196 1.7507 8.6399
5637 GDSC2 4.1261 8.1585 1.5367 9.1168
647V GDSC2 4.2123 6.2986 2.494 3.1485
RT-4 GDSC2 4.4042 8.9829 1.3348 9.6582
639V GDSC2 4.7612 6.2202 2.8247 0.7222
SW1710 GDSC2 4.8646 12.4115 -0.0101 15.8248
SW780 GDSC2 4.8722 9.345 1.4838 7.7562
HT-1376 GDSC2 5.0705 9.7318 1.4308 7.657
J82 GDSC2 5.2198 8.3449 2.1601 3.3328
UM-UC-3 GDSC2 5.9644 7.4708 2.8395 0.1443
TCCSUP GDSC2 6.0825 7.3963 2.9045 0.059
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TC-YIK GDSC2 1.8611 4.93 1.1177 18.8486
NEC8 GDSC2 1.9071 3.5602 1.7068 15.2699
Ca Ski GDSC2 2.0756 4.2213 1.6426 14.9174
PA-1 GDSC2 2.8097 5.7141 1.6761 12.0018
NT2-D1 GDSC2 3.2698 6.1162 1.8811 9.2692
KGN GDSC2 3.6332 8.6751 0.9001 14.1929
HEY GDSC2 3.6439 5.9347 2.2732 5.7603
BPH-1 GDSC2 3.7037 10.3849 0.1033 18.2963
HeLa GDSC2 3.8817 5.4835 2.6646 2.7882
C-33 A GDSC2 3.9173 7.279 1.815 7.9284
CAL-39 GDSC2 3.9181 12.5637 -0.812 21.8832
SKG-IIIa GDSC2 4.0747 6.1622 2.4695 3.5607
SKN GDSC2 4.1341 6.8433 2.1835 5.1586
OVMIU GDSC2 4.2642 8.8717 1.2878 10.2691
PEO1 GDSC2 4.2741 8.6921 1.3831 9.6808
DoTc2 4510 GDSC2 4.3359 6.8234 2.3269 3.889
HT-3 GDSC2 4.3607 7.7171 1.9182 6.2714
SiHa GDSC2 4.3826 10.0187 0.8111 12.7193
HEC-1 GDSC2 4.4426 6.1777 2.6844 1.7168
DSH1 GDSC2 4.6265 6.5396 2.6262 1.7625
LB831-BLC GDSC2 4.8286 7.9238 2.1224 4.1665
OVCA420 GDSC2 4.898 10.9533 0.7265 11.9605
SiSo GDSC2 4.9417 11.4405 0.5205 12.9605
PWR-1E GDSC2 5.0638 8.8778 1.8266 5.42
NCC-IT GDSC2 5.3357 7.5261 2.5669 1.2459
ME-180 GDSC2 5.4114 14.1996 -0.4892 16.7672
SW756 GDSC2 5.4943 6.9404 2.8537 0.2391
C-4-I GDSC2 5.6438 7.4022 2.7455 0.4296
MS751 GDSC2 5.7822 7.9419 2.6012 0.7759
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2 Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma. Cancer Cell. 2017 Jan 9;31(1):50-63.