Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBULX4)

• Drug Name: Ethylene diamine Drug Info
• Synonyms: ethylenediamine; Ethane-1,2-diamine; 1,2-Ethanediamine; 107-15-3; 1,2-Diaminoethane; Ethylene diamine; Ethylendiamine; Dimethylenediamine; edamine; 1,2-Ethylenediamine; Aethaldiamin; Ethyleendiamine; Aethylenediamin; Ethylene-diamine; beta-Aminoethylamine; 1,2-Diaminoaethan; Amerstat 274; Algicode 106L; 1,2-Diamino-ethano; 1,2-Diamino-ethaan; Aethaldiamin [German]; Caswell No. 437; Ethylenediamine [JAN]; Ethyleendiamine [Dutch]; 1,2-Ethanediamine, homopolymer; Aethylenediamin [German]; Ethylene-diamine [French]; NCI-C60402

Indication

Disease Entry	ICD 11	Status	REF
Tuberculosis	1B10-1B1Z	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3301
  ChEBI ID: CHEBI:30347
  CAS Number: CAS 107-15-3
  TTD Drug ID: DMBULX4
  INTEDE Drug ID: DR2030

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[5]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[6]
Doripenem	DM9UCJK	Cholecystitis		Approved	[7]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[8]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[9]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[10]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[11]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[12]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[7]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[7]

Drug(s) Metabolized By Putrescine acetyltransferase (SSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[13]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[2]
N1-(2-aminoethyl)ethane-1,2-diamine	DM6HM5S	Discovery agent	N.A.	Investigative	[2]
Propandiamine	DMQ9USH	N. A.	N. A.	Investigative	[2]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[14]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[17]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[22]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[20]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[32]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Putrescine acetyltransferase (SSAT1) Main DME	DEMWO83	SAT1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Gene/Protein Processing	[3]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[4]

References

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