Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC14KV)

Drug Name

GSK1995057 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Adult respiratory distress syndrome	CB00	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Tumor necrosis factor receptor type I (TNF-R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VB-111	DMX04CA	Malignant glioma	2A00.0	Phase 3	[3]
Drug 2862277	DM8WU3O	Acute lung injury	NB32.3	Phase 2	[4]
AVX-470	DMAKD0I	Inflammatory bowel disease	DD72	Phase 1	[5]
Anti-IFN gamma	DMXI185	Alopecia	ED70	Terminated	[5]
TNFR1 NAM	DMPTQEG	Multiple sclerosis	8A40	Investigative	[4]
NM-9405	DMKMBSJ	Rheumatoid arthritis	FA20	Investigative	[4]
TNFmab	DM4T0ZF	Rheumatoid arthritis	FA20	Investigative	[5]
ADS-0101	DMP7IS0	Chronic obstructive pulmonary disease	CA22	Investigative	[4]
Recombinant human TNF receptor	DMLYQWV	Arthritis	FA20	Investigative	[5]
TNFcept	DMAGI7K	Rheumatoid arthritis	FA20	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor receptor type I (TNF-R1)	TTG043C	TNR1A_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT01587807) A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057. U.S. National Institutes of Health.
2	Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-alpha receptor 1. J Clin Immunol. 2013 Oct;33(7):1192-203.
3	Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870).
5	Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.