Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCFNMK)

Drug Name

NSC-40331 Drug Info

Synonyms

NSC-40331; 6312-41-0; CHEMBL1165143; DTXSID30676757; NSC40331; 2-(4-(4-(diethylamino)phenylamino)phenyl)-1-phenylethanone, hydrochloride; 2-{4-[4-(Diethylamino)anilino]phenyl}-1-phenylethan-1-one--hydrogen chloride (1/1)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 46848006
CAS Number: CAS 6312-41-0
TTD Drug ID: DMCFNMK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cholesteryl ester transfer protein (CETP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Evacetrapib	DMCDZ15	Cardiovascular disease	BA00-BE2Z	Phase 3	[2]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[3]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[4]
JTT-302	DMGLVBI	Lipid metabolism disorder	5C52.Z	Phase 2	[2]
DRL-17822	DMGD3XT	Arteriosclerosis	BD40	Phase 2	[2]
TA-8995	DMAZHT0	Cardiovascular disease	BA00-BE2Z	Phase 2	[5]
BAY-60-5521	DMXIDWE	Arteriosclerosis	BD40	Phase 1	[6]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[7]
CETi-1	DMUG5OB	Arteriosclerosis	BD40	Discontinued in Phase 2	[8]
CP-800569	DMZ0YU7	Arteriosclerosis	BD40	Discontinued in Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholesteryl ester transfer protein (CETP)	TTFQAYR	CETP_HUMAN	Inhibitor	[1]

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References

1	Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic expl... Eur J Med Chem. 2010 Apr;45(4):1598-617.
2	The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8.
3	Clinical pipeline report, company report or official report of Roche (2009).
4	Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (C... Br J Clin Pharmacol. 2009 May;67(5):520-6.
5	Amgen To Acquire Privately-Held Dezima Pharma
6	Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein. Br J Clin Pharmacol. 2012 Feb;73(2):210-8.
7	Safety and tolerability of dalcetrapib. Am J Cardiol. 2009 Jul 1;104(1):82-91.
8	CETi-1. AVANT. Curr Opin Investig Drugs. 2004 Mar;5(3):334-8.
9	Pfizer. Product Development Pipeline. March 31 2009.