Details of the Drug

General Information of Drug (ID: DMKNCVM)

Drug Name
Dalcetrapib
Synonyms JTT 705; JTT-705; R-1658; RG-1658; RO-4607381; S-[2-[[1-(2-ethylbutyl)cyclohexanecarbonyl]amino]phenyl] 2-methylpropanethioate
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Phase 3 [1]
Hyperlipidaemia 5C80 Phase 3 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 389.6
Logarithm of the Partition Coefficient (xlogp) 7.1
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C23H35NO2S
IUPAC Name
S-[2-[[1-(2-ethylbutyl)cyclohexanecarbonyl]amino]phenyl] 2-methylpropanethioate
Canonical SMILES
CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C
InChI
InChI=1S/C23H35NO2S/c1-5-18(6-2)16-23(14-10-7-11-15-23)22(26)24-19-12-8-9-13-20(19)27-21(25)17(3)4/h8-9,12-13,17-18H,5-7,10-11,14-16H2,1-4H3,(H,24,26)
InChIKey
YZQLWPMZQVHJED-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
6918540
ChEBI ID
CHEBI:95001
CAS Number
211513-37-0
UNII
3D050LIQ3H
DrugBank ID
DB12181
TTD ID
D05SSC
INTEDE ID
DR1890
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholesteryl ester transfer protein (CETP) TTFQAYR CETP_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Post-Translational Modifications [5]
Cytochrome b-245 heavy chain (CYBB) OTGSG868 CY24B_HUMAN Gene/Protein Processing [5]
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Gene/Protein Processing [5]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Gene/Protein Processing [5]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Gene/Protein Processing [5]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Gene/Protein Processing [5]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Gene/Protein Processing [5]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Gene/Protein Processing [5]
NADPH oxidase 5 (NOX5) OTHTH59G NOX5_HUMAN Gene/Protein Processing [5]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acute coronary syndrome
ICD Disease Classification BA41
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cholesteryl ester transfer protein (CETP) DTT CETP 8.86E-01 -0.1 -0.6
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 5.08E-01 -8.08E-02 -5.30E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 9.9676 11.9075 7.3879 1.3588
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 9.447 13.2004 6.5243 8.7387
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.6308 8.1341 4.5414 0.9231
GaMG CTRP1 7.6736 9.0684 4.6037 0.144
LN-229 CTRP1 9.1997 11.3983 7.2081 3.9272
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-59 CTRP1 6.8546 9.0628 4.2721 2.2005
HEC-6 CTRP1 6.9246 8.2479 4.6181 0.3737
HEC-265 CTRP1 6.9405 8.1705 4.6513 0.2678
HEC-151 CTRP1 6.9858 7.932 6.9183 15.6861
HEC-251 CTRP1 6.9934 8.5444 4.5374 0.622
HEC-108 CTRP1 7.0928 8.2693 4.6718 0.1663
MFE-319 CTRP1 7.1071 9.893 4.0506 3.2465
KLE CTRP1 7.4841 9.2248 4.4815 0.5116
JHUEM-2 CTRP1 8.7996 10.4176 7.4162 3.2399
Ishikawa (Heraklio) 02 ER- CTRP1 6.1351 7.7182 4.4737 2.0587
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BL-70 CTRP1 5.4803 7.5688 4.1278 6.6711
HT CTRP1 6.1349 8.9418 3.9159 6.4609
KMS-11 CTRP1 6.3377 7.4763 6.3009 24.7104
MC116 CTRP1 6.3597 7.2223 4.7697 0.1955
PL21 CTRP1 6.9015 8.8323 6.5209 19.3844
Ku812 CTRP1 7.2091 8.8392 4.5146 0.5611
P3HR-1 CTRP1 7.4431 8.974 4.5547 0.3153
KE-97 CTRP1 7.4862 8.752 4.6453 0.1188
NOMO-1 CTRP1 8.0567 12.0867 6.0364 17.5375
SU-DHL-5 CTRP1 8.0941 9.2859 7.4675 5.0541
LP-1 CTRP1 8.2396 9.4401 7.505 4.1657
WSU-DLCL2 CTRP1 8.8834 10.6086 7.3794 3.3273
SU-DHL-4 CTRP1 9.0432 10.4743 7.5301 1.8293
RPMI-8226 CTRP1 9.4337 11.0788 7.4731 1.5624
NU-DUL-1 CTRP1 9.4867 11.5506 7.3012 2.6265
EJM CTRP1 9.5584 11.5257 7.3488 2.1729
GDM-1 CTRP1 9.5919 12.4058 6.9822 4.7728
SKM-1 CTRP1 9.6385 10.8791 7.6407 0.469
U-937 CTRP1 9.8425 11.3375 7.5532 0.6724
MOLM-16 CTRP1 10.0112 11.7088 7.4834 0.8376
AMO1 CTRP1 10.043 11.278 7.6511 0.2279
THP-1 CTRP1 10.0776 11.6482 7.5327 0.5807
OCI-AML-3 CTRP1 10.2 11.6562 7.5766 0.3616
OCI-Ly10 CTRP1 10.2511 14.0929 6.6048 6.1106
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.2119 8.9851 4.4622 0.7641
RCC10RGB CTRP1 9.8778 11.1132 7.6483 0.3046
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CW-2 CTRP1 3.2542 7.9206 2.8508 62.3172
SNU-C5 CTRP1 5.5841 8.3773 5.2626 37.1445
DLD-1 CTRP1 5.9602 7.0987 4.6468 1.1763
SW480 CTRP1 6.0663 8.371 5.7894 30.3044
LS513 CTRP1 6.1569 8.6335 4.0742 5.1063
COLO 320 CTRP1 6.3177 10.848 5.034 33.1003
SW48 CTRP1 6.5418 8.3546 4.412 1.7868
LS411N CTRP1 6.6039 7.9335 4.6066 0.6377
SK-CO-1 CTRP1 6.62 8.4691 4.4028 1.7274
SW403 CTRP1 7.0734 9.057 4.3763 1.301
GP2d CTRP1 7.1661 8.5872 4.5883 0.3434
C2BBe1 CTRP1 7.1728 9.1583 4.3803 1.1748
COLO205 CTRP1 7.2979 8.6237 4.6233 0.2049
SNU-C2A CTRP1 7.408 10.23 4.0601 2.6998
LS180 CTRP1 7.5408 8.165 7.4588 7.8849
SW620 CTRP1 7.5968 9.965 6.6921 14.2008
SNU-C4 CTRP1 7.7066 10.5985 6.4786 15.5159
SNU-1040 CTRP1 8.3067 9.7486 7.403 4.8356
HCT 116 CTRP1 8.4028 10.5855 7.062 7.5226
KM12 CTRP1 8.6234 12.3442 6.3591 12.7356
LS123 CTRP1 8.7593 11.3431 6.9496 7.3
SNU-61 CTRP1 9.1762 11.0706 7.3418 2.9472
SW948 CTRP1 9.1879 11.7549 7.0371 5.3255
HT-29 CTRP1 9.2509 10.72 7.5321 1.4638
NCI-H508 CTRP1 9.463 13.4357 6.4231 9.4837
HT115 CTRP1 9.5878 10.8402 7.6349 0.5294
RCM-1 [Human ESC] CTRP1 9.6035 10.8271 7.646 0.4733
HCT 8 CTRP1 9.6503 10.6895 7.713 0.2248
MDST8 CTRP1 9.7527 11.0612 7.6192 0.4732
SNU-81 CTRP1 9.7544 12.4788 7.0418 3.975
LoVo CTRP1 9.7545 11.8107 7.3274 2.0013
CL-34 CTRP1 9.9073 11.4004 7.556 0.6105
CL-40 CTRP1 10.1545 11.4772 7.6225 0.2564
HT-55 CTRP1 10.2105 11.4437 7.6538 0.1686
COLO 678 CTRP1 10.2918 12.2405 7.3993 0.9716
SNU-175 CTRP1 10.335 11.9812 7.5119 0.4944
RKO CTRP1 10.8962 12.1464 7.6525 0.0544
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 5.8965 7.2303 4.5572 1.9174
SNU-398 CTRP1 6.6801 7.8725 6.5992 20.1512
SNU-449 CTRP1 7.2119 11.0515 3.6009 6.2259
Hep-G2 CTRP1 9.7502 10.9436 7.6606 0.3311
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1963 CTRP1 1.3297 10.2223 0.0256 67.945
NCI-H82 CTRP1 4.3881 7.7095 3.1344 19.8763
NCI-H1373 CTRP1 4.9857 6.5766 4.2316 7.6302
NCI-H1836 CTRP1 5.0399 8.646 4.5846 44.4857
NCI-H1573 CTRP1 5.0471 7.0053 4.0691 8.8327
SHP-77 CTRP1 5.2649 7.7495 3.874 9.7005
HARA [Human squamous cell lung carcinoma] CTRP1 5.4301 7.0514 4.3448 4.9301
HCC44 CTRP1 5.5576 7.9993 3.9731 7.764
NCI-H1568 CTRP1 5.7314 8.1192 4.0385 6.6257
Lu-99 CTRP1 5.7567 7.1948 4.4926 2.7298
NCI-H1355 CTRP1 5.7982 7.6306 4.3162 4.0684
NCI-H3255 CTRP1 5.8153 8.2113 5.565 33.6011
KNS-62 CTRP1 5.8298 9.2694 3.5487 10.457
NCI-H661 CTRP1 5.9323 9.4679 3.5252 10.3082
NCI-H1437 CTRP1 5.9464 8.5732 3.9668 6.5801
NCI-H23 CTRP1 5.9721 7.8806 4.3083 3.6803
Lu-65 CTRP1 6.0008 8.449 4.0615 5.6311
Calu-6 CTRP1 6.0593 7.9028 4.35 3.1425
A-549 CTRP1 6.0895 8.0847 4.2854 3.5794
NCI-H1105 CTRP1 6.1054 11.2606 4.6323 36.2345
ChaGo-K-1 CTRP1 6.1543 8.8389 3.9768 5.9073
NCI-H1944 CTRP1 6.1757 8.6261 4.0893 4.9355
NCI-H1048 CTRP1 6.2054 7.7658 4.4901 1.8171
NCI-H727 CTRP1 6.214 8.7623 4.0499 5.1549
BEN CTRP1 6.2191 7.3542 4.6645 0.729
NCI-H2126 CTRP1 6.4341 7.6996 4.6241 0.7109
LCLC-103H CTRP1 6.52 7.9878 4.5498 1.0007
NCI-H2029 CTRP1 6.5928 8.1371 4.5236 1.0582
EBC-1 CTRP1 6.6438 9.3402 4.0413 4.2106
LCLC-97TM1 CTRP1 6.7512 11.0953 3.2993 9.6143
HCC78 CTRP1 6.8089 8.5657 4.4515 1.1985
Calu-3 CTRP1 6.8294 8.5589 4.4633 1.1134
NCI-H810 CTRP1 6.851 8.1845 4.6127 0.4339
COR-L88 CTRP1 6.8928 8.2877 4.5916 0.4835
NCI-H2009 CTRP1 6.8972 8.6321 4.4643 1.0363
NCI-H522 CTRP1 6.9104 8.9352 4.3508 1.6389
NCI-H1792 CTRP1 6.9404 8.6883 4.4613 1.0079
NCI-H1930 CTRP1 6.9753 8.5662 4.522 0.6987
NCI-H2122 CTRP1 6.976 8.76 6.6288 18.0602
NCI-H1435 CTRP1 6.9843 8.8576 4.4149 1.197
NCI-H2286 CTRP1 7.0164 8.2218 4.661 0.214
COLO 668 CTRP1 7.0232 8.6892 4.4957 0.773
NCI-H1793 CTRP1 7.097 8.7456 4.5046 0.6772
DV-90 CTRP1 7.1352 8.752 4.5175 0.5994
LXF 289 CTRP1 7.1647 9.1769 4.3696 1.2371
LC-1/sq-SF CTRP1 7.1685 8.6848 4.5546 0.4467
RERF-LC-KJ CTRP1 7.2067 8.8737 4.5011 0.6128
HCC33 CTRP1 7.2779 9.0389 4.4688 0.6882
DMS 273 CTRP1 7.3323 8.8639 4.5526 0.3692
VMRC-LCD CTRP1 7.3668 9.2209 4.4372 0.7491
COR-L279 CTRP1 7.3782 8.5984 4.6596 0.1188
HCC1833 CTRP1 7.4035 8.8301 7.0437 12.1387
HCC4006 CTRP1 7.4224 9.7654 6.6254 15.6423
NCI-H650 CTRP1 7.4709 9.0084 4.5528 0.3089
SCLC-21H CTRP1 7.5246 8.1445 7.448 8.0718
EPLC-272H CTRP1 7.5402 9.2622 4.4894 0.4565
NCI-H1975 CTRP1 7.5673 9.095 4.5576 0.2619
NCI-H358 CTRP1 7.6653 9.182 4.5625 0.2202
NCI-H1876 CTRP1 7.7345 9.3791 7.1065 9.8881
NCI-H1666 CTRP1 7.7897 9.6471 4.4465 0.4627
NCI-H1299 CTRP1 7.7913 13.331 2.9086 9.7125
NCI-H1694 CTRP1 7.8415 10.1407 6.8254 11.8927
NCI-H2405 CTRP1 7.9316 9.7157 4.4744 0.3283
NCI-H1915 CTRP1 7.9408 9.3979 4.5849 0.1202
HCC15 CTRP1 8.0642 9.9038 7.1341 8.1777
NCI-H841 CTRP1 8.0691 9.7996 7.1902 7.6531
HCC2108 CTRP1 8.0704 9.4667 7.3578 6.1392
NCI-H2342 CTRP1 8.0985 10.4886 6.87 10.3961
HCC1359 CTRP1 8.1289 9.1189 7.579 3.9141
COLO 699 CTRP1 8.2121 9.5587 7.4252 4.9796
HCC1195 CTRP1 8.5276 10.5551 7.1688 6.1519
CAL-12T CTRP1 8.5507 10.4707 7.2263 5.5729
COR-L51 CTRP1 9.1103 11.692 7.0176 5.692
NCI-H596 CTRP1 9.1202 10.8054 7.4277 2.4217
NCI-H2141 CTRP1 9.1871 10.8292 7.4534 2.1054
NCI-H2110 CTRP1 9.2033 14.9434 5.5099 16.9154
HCC2935 CTRP1 9.2937 12.2768 6.8603 6.4773
NCI-H441 CTRP1 9.3155 11.0541 7.4243 2.0766
NCI-H460 CTRP1 9.5143 11.2968 7.4225 1.7616
Sq-1 CTRP1 9.5674 11.0227 7.5571 0.91
NCI-H2030 CTRP1 9.6379 11.8837 7.2377 2.7951
NCI-H1781 CTRP1 9.7279 11.7658 7.3329 2.0066
NCI-H2172 CTRP1 9.7856 14.8272 5.9749 11.8884
SK-LU-1 CTRP1 9.9142 12.157 7.2623 2.172
NCI-H2081 CTRP1 9.995 11.5267 7.5445 0.5924
COR-L23 CTRP1 10.0101 11.2786 7.639 0.2714
HCC827 CTRP1 10.1019 11.8113 7.4822 0.7666
NCI-H2023 CTRP1 10.1034 11.7107 7.52 0.6117
T3M-10 CTRP1 10.1321 12.4983 7.2272 2.0729
NCI-H2073 CTRP1 10.2317 11.6089 7.6047 0.271
NCI-H1755 CTRP1 10.3772 11.9956 7.5227 0.4368
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 6.6956 8.4854 4.4319 1.447
KYSE-410 CTRP1 7.3796 9.0283 4.5121 0.4694
KYSE-140 CTRP1 7.8526 9.9615 4.358 0.7188
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COV434 CTRP1 6.134 8.4053 5.852 29.3974
HEY A8 CTRP1 6.1801 8.673 4.0702 5.0779
OVCAR-4 CTRP1 6.3282 8.9484 5.8667 27.9905
OVMANA CTRP1 6.3958 10.4412 3.3757 10.0505
OVCAR-8 CTRP1 6.6532 7.7298 6.5994 20.3311
COV318 CTRP1 6.7138 7.5108 4.7955 0.0523
OVKATE CTRP1 6.7423 7.3657 6.7367 18.704
A2780 CTRP1 7.0119 8.4002 6.805 16.4095
SK-OV-3 CTRP1 7.4559 8.5761 4.6931 0.0646
EFO-21 CTRP1 7.4562 8.8037 4.6176 0.1712
IGROV-1 CTRP1 7.5699 8.3607 7.4171 8.0472
JHOS-4 CTRP1 7.7707 9.6902 4.4241 0.5413
OVK18 CTRP1 7.8727 9.951 6.9472 10.6724
JHOC-5 CTRP1 8.1751 8.9162 7.7153 2.522
COV644 CTRP1 8.8711 10.7191 7.3208 3.8357
OV-90 CTRP1 8.9475 10.9668 7.2534 4.189
JHOM-1 CTRP1 9.0775 11.6226 7.0292 5.6861
OAW42 CTRP1 9.3113 10.3526 7.704 0.456
RMUG-S CTRP1 9.4561 15.6041 5.3701 16.9723
RMG-I CTRP1 9.6842 13.6493 6.4659 8.5337
OV7 CTRP1 9.9146 11.4942 7.5241 0.739
Caov-3 CTRP1 10.0419 11.4058 7.6061 0.3506
SNU-840 CTRP1 10.1587 12.0026 7.4338 0.9325
COV362 CTRP1 10.1621 11.7521 7.5279 0.5429
TYK-nu CTRP1 10.2542 11.8019 7.5453 0.4302
EFO-27 CTRP1 10.4399 12.0249 7.5358 0.3678
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CFPAC-1 CTRP1 6.1068 8.8733 3.93 6.4237
Panc 10.05 CTRP1 6.5827 8.5992 4.3302 2.2574
HPAC CTRP1 6.6377 8.601 4.357 1.9916
SUIT-2 CTRP1 6.8817 8.6258 4.4601 1.074
PaTu 8902 CTRP1 7.012 8.5001 4.5609 0.5188
KP-3 CTRP1 7.1199 10.1923 3.929 4.0624
Panc 03.27 CTRP1 7.1859 8.7287 4.5456 0.4669
QGP-1 CTRP1 7.3052 8.681 4.6063 0.2402
HuP-T4 CTRP1 7.561 9.1626 4.532 0.3265
Capan-2 CTRP1 8.1215 9.9853 4.4495 0.3194
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 4.4865 6.4118 3.8563 13.3187
NCI-H28 CTRP1 5.69 8.0023 4.0663 6.5171
NCI-H2052 CTRP1 7.2645 9.038 4.4638 0.7179
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 6.9058 8.3038 4.5908 0.4781
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 936.T CTRP1 6.7689 7.727 4.7423 0.1194
Hs 852.T CTRP1 7.4455 9.2303 4.4648 0.5915
COLO 741 CTRP1 7.4633 9.0157 4.5475 0.3257
G-361 CTRP1 7.478 8.9232 4.5847 0.231
Hs 944.T CTRP1 7.6693 9.2404 4.5441 0.2582
SK-MEL-5 CTRP1 8.4716 10.036 7.3816 4.4718
SK-MEL-28 CTRP1 9.2223 10.0924 7.7642 0.2847
A-375 CTRP1 9.3508 11.2158 7.3735 2.3674
SK-MEL-1 CTRP1 9.5985 10.7911 7.6571 0.4339
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN CTRP1 5.9618 8.1287 5.7489 31.3194
G-401 CTRP1 7.2605 10.1241 4.0312 3.1165
HT-1080 CTRP1 9.7147 12.1645 7.1573 3.2184
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 CTRP1 6.3422 9.4617 3.8046 6.7962
SH-10-TC CTRP1 6.615 8.1097 4.5441 0.9263
MKN7 CTRP1 6.749 8.8556 4.3061 2.1459
Fu97 CTRP1 7.0341 8.8168 4.452 0.9622
MKN74 CTRP1 7.457 10.7579 3.8634 3.8951
AGS CTRP1 7.9215 8.6933 7.6151 4.4695
SNG-M CTRP1 6.6199 8.6323 4.335 2.1633
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.2016 8.5243 4.1519 4.3683
SCC-9 CTRP1 10.2487 11.7571 7.5591 0.3901
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP1 6.0624 8.7982 3.9366 6.4954
UM-UC-3 CTRP1 6.637 8.686 4.3211 2.2279
RT-4 CTRP1 6.9978 9.8262 4.0222 3.6395
HT-1376 CTRP1 7.6595 9.374 4.4943 0.386
KMBC-2 CTRP1 7.7275 9.572 4.4498 0.4833

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT00658515) A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of Roche (2009).
4 In vitro and in vivo assessment of the effect of dalcetrapib on a panel of CYP substrates. Curr Med Res Opin. 2009 Apr;25(4):891-902.
5 Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.