Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCG7XL)

• Drug Name: AMG 910 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Esophagogastric junction neoplasm	2B71	Phase 1	[1]
Gastric adenocarcinoma	2B72	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMCG7XL

Molecule-Related Drug Atlas

Drug(s) Targeting T-cell surface glycoprotein CD3 (CD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Blinatumomab	DMGECIJ	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Mosunetuzumab	DM15ZIB	Follicular lymphoma	2A80	Approved	[4]
Epcoritamab	DMEX86V	Diffuse large B-cell lymphoma	2A81	Approved	[5]
Talquetamab	DMXRENI	Multiple myeloma	2A83	Approved	[6]
Elranatamab	DMG1MW2	Multiple myeloma	2A83	Approved	[7]
Nivatrotamab	DMAOUZV	Small-cell lung cancer	2C25.Y	Phase 2	[8]
Otelixizumab	DMFNDBC	Type-1 diabetes	5A10	Phase 2	[9]
Plamotamab	DMOV28A	Diffuse large B-cell lymphoma	2A81	Phase 2	[10]
Odronextamab	DMP6NVV	B-cell non-hodgkin lymphoma	2B33.5	Phase 2	[11]
Tarlatamab	DME33OU	Small-cell lung cancer	2C25.Y	Phase 2	[12]

Drug(s) Targeting Claudin-18 (CLDN18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Claudiximab	DMPQR1D	Gastric adenocarcinoma	2B72	Phase 3	[13]
Zolbetuximab	DM5ST9Z	Esophagogastric junction neoplasm	2B71	Phase 3	[14]
CT-041	DM5XX06	Gastric cancer	2B72	Phase 1/2	[15]
RC118	DMU25QT	Aggressive cancer	2A00-2F9Z	Phase 1/2	[16]
TST001	DMZ9EMO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[17]
SKB315	DMI0JT4	Aggressive cancer	2A00-2F9Z	Phase 1	[18]
ASP2138	DM96QLF	Stomach cancer	2B72	Phase 1	[19]
CAR-CLD18 T cell	DM6ZHTV	Adenocarcinoma	2D40	Clinical trial	[20]
BNT212	DM27NTT	Aggressive cancer	2A00-2F9Z	Preclinical	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Claudin-18 (CLDN18)	TT6PKBX	CLD18_HUMAN	Inhibitor	[2]
T-cell surface glycoprotein CD3 (CD3)	TTUN7MC	NOUNIPROTAC	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT04260191) Study of AMG 910 in Subjects With CLDN18.2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of Amgen.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling. NPJ Syst Biol Appl. 2020 Aug 28;6(1):28.
• [5] Clinical pipeline report, company report or official report of Genmab.
• [6] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761342
• [7] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761345
• [8] Clinical pipeline report, company report or official report of Y-mAbs Therapeutics.
• [9] Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes.Diabetes Care.2014 Oct;37(10):2746-54.
• [10] Plamotamab (XmAb(?)13676) for Ibrutinib- refractory CXCR4-mutated extramedullary Waldenstr?m macroglobulinemia. Leuk Lymphoma. 2022 Mar;63(3):738-742.
• [11] Odronextamab, a human CD20*CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial. Lancet Haematol. 2022 May;9(5):e327-e339.
• [12] Tarlatamab, a First-in-Class DLL3-Targeted Bispecific T-Cell Engager, in Recurrent Small-Cell Lung Cancer: An Open-Label, Phase I Study. J Clin Oncol. 2023 Jun 1;41(16):2893-2903.
• [13] Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms. Int J Cancer. 2014 Feb 1;134(3):731-9.
• [14] FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma. Ann Oncol. 2021 May;32(5):609-619.
• [15] Clinical pipeline report, company report or official report of CARSGEN
• [16] ClinicalTrials.gov (NCT05205850) An Open, Multi-center Phase I/IIa Clinical Study of RC118 for Injection in Patients With Locally Advanced Unresectable or Metastatic Malignant Solid Tumors With Positive Expression of Claudin 18.2. U.S.National Institutes of Health.
• [17] Clinical pipeline report, company report or official report of Transcenta.
• [18] Clinical pipeline report, company report or official report of Klus Pharma
• [19] ClinicalTrials.gov (NCT05365581) A Phase 1/1b Study of ASP2138 in Participants With Metastatic or Locally Advanced Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma or Metastatic Pancreatic Adenocarcinoma Whose Tumors Have Claudin (CLDN) 18.2 Expression. U.S.National Institutes of Health.
• [20] ClinicalTrials.gov (NCT03302403) Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors
• [21] Clinical pipeline report, company report or official report of Biontech