Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCHLJ4)

Drug Name

NS-004 Drug Info

Synonyms

NS004; NS-004; NS-O04; 1-(5-Chloro-2-hydroxyphenyl)-5-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one; WYLYBVMNGZOYOH-UHFFFAOYSA-N; AC1NSKFZ; ZINC5663; SCHEMBL8911620; GTPL4271; CHEMBL375448; SCHEMBL3102522; KB-09311; 1-[2-hydroxy-5-chlorophenyl]-5-trifluoromethyl-2-benzimidazolone; 3-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-1H-benzimidazol-2-one; 2H-benzimidazol-2-one, 1-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-5-(trifluoromethyl)-; 1,3-dihydro-1-(5-chloro-2-hydroxyphenyl)-5-trifluoromethyl-2H-benzimidazol-2-one

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Terminated	[1]

Cross-matching ID

PubChem CID: 5311330
TTD Drug ID: DMCHLJ4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Potassium channel unspecific (KC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[3]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[3]
Dronedarone	DMA8FS5	Angina pectoris	BA40	Approved	[4]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[3]
Amifampridine	DMK08L3	LambertEaton myasthenic syndrome	8C62	Approved	[5]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[3]
Pinacidil	DMRADYL	High blood pressure	BA00	Approved	[3]
Dalfampridine	DMM0PDO	Multiple sclerosis	8A40	Approved	[6]
Ibutilide	DMKXY2R	Atrial fibrillation	BC81.3	Approved	[3]
Diazoxide	DML1538	Congenital hyperinsulinism	5A4Y	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Potassium channel unspecific (KC)	TT1VOHK	NOUNIPROTAC	Opener	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4271).
2	Effects of K+ channel inhibitors and antagonists on NS-004 evoked relaxations in guinea-pig isolated trachea. Fundam Clin Pharmacol. 1997;11(1):78-82.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.