Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCHWX1)

Drug Name
Nedosiran Drug Info
Synonyms DCR-PHXC
Indication
Disease Entry ICD 11 Status REF
Primary hyperoxaluria type 1 5C51.20 Approved [1]
Hyperoxaluria 5C51.2 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMCHWX1

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LDHA messenger RNA (LDHA mRNA) TTW76JE LDHA_HUMAN Inhibitor [3]

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 215842
2 ClinicalTrials.gov (NCT04580420) Safety & Efficacy of DCR-PHXC in Patients With PH1/2 and ESRD (PHYOX7). U.S. National Institutes of Health.
3 Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria. Kidney Int Rep. 2021 Feb 3;6(4):1088-1098.