Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCOJIL)

• Drug Name: 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline Drug Info
• Synonyms: CHEMBL50166; 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline; SCHEMBL6159581; ZINC26870; BDBM50127827

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 18326767
  TTD Drug ID: DMCOJIL

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methamphetamine	DMPM4SK	Anxiety		Approved	[2]
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[3]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[4]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[5]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[7]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[8]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[9]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[10]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[11]

Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxazosin	DM9PLRH	Benign prostatic hyperplasia	GA90	Approved	[12]
Armodafinil	DMGB035	Malignant glioma	2A00.0	Approved	[13]
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[14]
Moxisylyte	DMFCLYW	Erectile dysfunction	HA01.1	Approved	[15]
Terazosin	DM3JCVS	Benign prostatic hyperplasia	GA90	Approved	[16]
Bunazosin	DM4I8O7	Glaucoma/ocular hypertension	9C61	Approved	[17]
Trimazosin	DM1QLST	Congestive heart failure	BD10	Approved	[18]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
DL-017	DMM8GZT	Hypertension	BA00-BA04	Phase 1	[19]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[20]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[21]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[22]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[23]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[24]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[25]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[26]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[27]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[28]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[29]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[30]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[31]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[23]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[32]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[33]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[34]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[35]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[24]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[36]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[37]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[25]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[38]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[38]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[39]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[40]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[41]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[42]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[6]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[20]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[20]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[7]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Inhibitor	[1]

References

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