Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD6CLG)

Drug Name

TZP-201 Drug Info

Synonyms

JTZ-2002; IBS-D therapeutic, Tranzyme; Irritable bowel syndrome (diarrhea type) therapeutic, Tranzyme; Motilin antagonists (IBS/ fuctional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/ functional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/diarrhea), Tranzyme

Indication

Disease Entry	ICD 11	Status	REF
Diarrhea	ME05.1	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMD6CLG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Motilin receptor (MLNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOTILIN	DMVILAD	N. A.	N. A.	Phase 4	[2]
Camicinal	DMAKSMX	Delayed gastric emptying	DA41.00	Phase 2	[1]
Mitemcinal fumarate	DMOJ7QA	Pain	MG30-MG3Z	Phase 2	[3]
RWJ-68023	DM4O07Q	Irritable bowel syndrome	DD91.0	Phase 1	[4]
KOS-2187	DM4953W	Gastroesophageal reflux disease	DA22.Z	Phase 1	[5]
DS-3801	DM6WN9X	Constipation	DD91.1	Phase 1	[6]
GSK-1322888	DMNYGB8	Gastroparesis	DA41.00	Phase 1	[7]
KW-5139	DMLOKXI	Pain	MG30-MG3Z	Discontinued in Phase 2	[8]
KC-11458	DMOITN2	Gastric motility disorder	DA21	Discontinued in Phase 2	[9]
SLV-305	DMBZM0D	Gastric motility disorder	DA21	Discontinued in Phase 2	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Motilin receptor (MLNR)	TT953CX	MTLR_HUMAN	Antagonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).
2	Discovery of a new class of macrocyclic antagonists to the human motilin receptor. J Med Chem. 2006 Nov 30;49(24):7190-7.
3	Clinical pipeline report, company report or official report of Roche (2009).
4	Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function. Br J Clin Pharmacol. 2004 Apr;57(4):393-401.
5	Kosan Announces Selection of KOS-2187 As Motilide Clinical Candidate at World Congress of Gastroenterology Meeting. Kosan. 2006.
6	Clinical pipeline report, company report or official report of Daiichi Sankyo.
7	ClinicalTrials.gov (NCT01294566) FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers. U.S. National Institutes of Health.
8	Stimulating action of KW-5139 (Leu13-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol. 1994 Jan;111(1):288-94.
9	Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004 Aug 1;20(3):333-8.