Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD741P)

Drug Name

Alagebrium chloride Drug Info

Synonyms

PTB; Tetrazolium chloride; ALT-711; ALT-766; N-phenacylthiazolium bromide; Advanced glycosylation end product (AGE)breakers, Alteon; Advanced glycosylation end product (AGE) breakers, Synvista

Indication

Disease Entry	ICD 11	Status	REF
Hypotension	BA20-BA21	Phase 2/3	[1]

Cross-matching ID

PubChem CID: 216306
CAS Number: CAS 341028-37-3
TTD Drug ID: DMD741P

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Advanced glycosylation end product receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyridoxamine	DMVDCGZ	Diabetic kidney disease	GB61.Z	Phase 3	[3]
PF-4494700	DMJ7IKW	Alzheimer disease	8A20	Phase 3	[4]
TTP-448	DMR37X8	Alzheimer disease	8A20	Phase 2	[4]
TTP-4000	DMCG01R	Alzheimer disease	8A20	Phase 1	[5]
DBT-066	DMFYCQ1	Dementia	6D80-6D86	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Advanced glycosylation end product receptor (AGER)	TTMO9HF	RAGE_HUMAN	Breaker	[2]

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References

1	ClinicalTrials.gov (NCT01417663) Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function. U.S. National Institutes of Health.
2	Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58.
3	Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice. Protein Pept Lett. 2010 Sep;17(9):1177-81.
4	Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9.
5	Receptor for advanced glycation end products: its role in Alzheimer's disease and other neurological diseases. Future Neurol. 2009; 4(2): 167-177.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2843).