Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD7Z3H)

• Drug Name: Benzylcinnamate Drug Info
• Cross-matching ID:
  PubChem CID: 5273469
  ChEBI ID: CHEMBL146174
  CAS Number: CAS 103-41-3
  TTD Drug ID: DMD7Z3H

Molecule-Related Drug Atlas

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[4]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[5]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[6]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[7]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[8]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[9]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[10]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[11]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[12]
Budipine	DMODHQI	Migraine	8A80	Approved	[13]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[14]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[14]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[28]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[29]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[32]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[37]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[2]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[3]
Thioredoxin	OT6XU6VW	THIO_HUMAN	Gene/Protein Processing	[2]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Gene/Protein Processing	[2]

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