Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDIYFH)

Drug Name

PRE-084 Drug Info

Synonyms

Pre-084; 138847-85-5; 2-Morpholinoethyl 1-Phenylcyclohexanecarboxylate; 2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate; CHEMBL305881; 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate; Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester; Tocris-0589; Lopac-P-2607; AC1L2Q9Z; Lopac0_000927; PRE084; GTPL6678; SCHEMBL5564153; CHEBI:93007; DTXSID40160819; EX-A911; BCP25418; BDBM50039197; ZINC25756875; AKOS027439951; CCG-205008; NCGC00024669-03; NCGC00024669-02; NCGC00024669-01; NCGC00015808-04

Indication

Disease Entry	ICD 11	Status	REF
Aging skin	EE40	Terminated	[1]

Cross-matching ID

PubChem CID: 126402
ChEBI ID: CHEBI:93007
CAS Number: CAS 138847-85-5
TTD Drug ID: DMDIYFH

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[3]
Dextromethorphan Polistirex	DMEHCY5	Dry cough	MD12	Approved	[4]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[5]
AVP-786	DMV1SOR	Alzheimer disease	8A20	Phase 3	[6]
ADX N05	DMLBYRA	Mood disorder	6A60-6E23	Phase 3	[7]
Igmesine	DMH97XA	Major depressive disorder	6A70.3	Phase 2	[8]
OPC-14523	DMB1WF3	Bulimia nervosa	6B81	Phase 2	[9]
ANAVEX 2-73	DM67OU4	Alzheimer disease	8A20	Phase 1	[10]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[11]
SA-5845	DM6XZRL	Central nervous system disease	8A04-8D87	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6678).
2	Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacol Rep. 2009 Nov-Dec;61(6):1179-83.
3	Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
6	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
7	Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
8	Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
9	Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
10	2011 Pipeline of Anavex.
11	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
12	Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.