Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDP6UF)

Drug Name

SCH-721015 Drug Info

Synonyms

RAd-IFN, Merck & Co; RAd-IFN, Schering-Plough; Ad.hIFN-alpha2b, Merck & Co; Recombinant adenovirus vector expressing hybrid-interferon (bladder neoplasm), Merck & Co

Indication

Disease Entry	ICD 11	Status	REF
Mesothelioma	2C51.2	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMDP6UF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interferon-alpha 2 (IFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Peginterferon alfa-2b	DMAP58Y	Hepatitis C virus infection	1E51.1	Approved	[3]
Interferon Alfa-2b	DMWCQP4	Melanoma	2C30	Approved	[3]
Peginterferon alfa-2a	DMJI3BA	Chronic hepatitis B virus infection		Approved	[3]
Albinterferon alfa-2b	DMK0QW6	Hepatitis C virus infection	1E51.1	Phase 3	[4]
Interferon alpha 2a	DMOTH6V	Hepatitis C virus infection	1E51.1	Phase 3	[5]
Hebergel	DMQTLVB	Virus infection	1A24-1D9Z	Phase 3	[6]
P-1101	DM7WYXJ	Essential thrombocythemia	3B63.1Z	Phase 3	[7]
Interferon alpha-2b	DMVACTU	Hepatitis C virus infection	1E51.1	Phase 2	[8]
Novaferon	DMEHOI1	Colorectal cancer	2B91.Z	Phase 2	[9]
Instiladrin	DMNKAFQ	Bladder cancer	2C94	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-alpha 2 (IFNA2)	TTSIUJ9	IFNA2_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01162785) Phase IB Intravesical Administration of SCH 721015. U.S. National Institutes of Health.
2	Toxicity and exposure of an adenovirus containing human interferon alpha-2b following intracystic administration in cynomolgus monkeys. Gene Ther. 2012 Jul;19(7):742-51.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C. Curr Med Res Opin. 2009 Apr;25(4):991-1002.
5	Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. Blood. 1988 Aug;72(2):655-60.
6	Evaluation of recombinant human interferon alpha-2b structure and stability by in-gel tryptic digestion, H/D exchange and mass spectrometry. J Pharm Biomed Anal. 2006 Feb 24;40(3):781-7.
7	Effects of PEG-interferon-alpha-2A on Schistosoma mansoni infection in mice. J Parasitol. 2010 Aug;96(4):703-8.
8	Clinical pipeline report, company report or official report of Avarx.
9	Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-alpha, shows antitumor effect in vitro and in vivo. Cancer Cell Int. 2014; 14: 8.
10	ClinicalTrials.gov (NCT01687244) Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer. U.S. National Institutes of Health.