General Information of Drug (ID: DMDS8AN)

Drug Name
(2R,3S,4S,5R)-2-hexylpiperidine-3,4,5-triol Drug Info
Synonyms CHEMBL1090540; (2R,3S,4S,5R)-2-hexylpiperidine-3,4,5-triol; SCHEMBL19829307; BDBM50315255
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
46866608
TTD Drug ID
DMDS8AN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Drug(s) Targeting Glucosylceramidase (GBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Velaglucerase alfa DM4BOAS Gaucher disease type I Approved [2]
Taliglucerase alfa DM3PZXN Metabolic disorder 5C50-5D2Z Approved [3]
Isofagomine tartrate DM2RS0V Metabolic disorder 5C50-5D2Z Phase 2 [4]
Afegostat DMRWSKX Gaucher disease 5C56.0Y Discontinued in Phase 2 [5]
NCGC607 DMXG0O1 Gaucher disease 5C56.0Y Preclinical [6]
N-Octyl-beta-valienamine DM39C47 Gaucher disease 5C56.0Y Preclinical [7]
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose DMOUG6Y Discovery agent N.A. Investigative [8]
L-Isofagomine DM6RKOC Discovery agent N.A. Investigative [9]
(2R,3S,4S,5R)-2-propylpiperidine-3,4,5-triol DM7GI94 Discovery agent N.A. Investigative [1]
N-(Propylamide-acetophenone)-1-deoxynojirimycin DMXI4V8 Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucosylceramidase (GBA) TT1B5PU GLCM_HUMAN Inhibitor [1]

References

1 Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg Med Chem. 2010 Apr 1;18(7):2645-50.
2 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
3 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4 Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem. 2008 Nov 3;9(16):2650-62.
5 Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
6 A New Glucocerebrosidase Chaperone Reduces alpha-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. J Neurosci. 2016 Jul 13;36(28):7441-52.
7 Chemical modification of the beta-glucocerebrosidase inhibitor N-octyl-beta-valienamine: synthesis and biological evaluation of 4-epimeric and 4-O-(beta-D-galactopyranosyl) derivatives. Bioorg Med Chem. 2002 Jun;10(6):1967-72.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
10 Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorg Med Chem. 2010 Jan 1;18(1):267-73.