Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDSR1X)

• Drug Name: PD-157695 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 3854666
  ChEBI ID: CHEBI:93074
  CAS Number: CAS 182498-32-4
  TTD Drug ID: DMDSR1X

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D3 receptor (D3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cariprazine	DMJYDVK	Bipolar disorder	6A60	Approved	[4]
Pramipexole	DMNMW9R	Parkinson disease	8A00.0	Approved	[5]
Ropinirole	DMA6S1D	Parkinson disease	8A00.0	Approved	[5]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[6]
P2B-001	DM9PVHX	Parkinson disease	8A00.0	Phase 3	[7]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[8]
ONC201	DMM5SCF	Endometrial cancer	2C76	Phase 2	[9]
TAK-906	DMBQD9H	Diabetic gastroparesis	DA41.00	Phase 2	[10]
GSK598809	DMGU05N	Drug abuse	6C4G.1Z	Phase 2	[11]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[11]

Drug(s) Targeting C-X-C chemokine receptor type 2 (CXCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[12]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[13]
Reparixin	DMVBA7I	Pancreatic islet transplantation failure	NE84	Phase 3	[12]
SCH-527123	DMPUAOE	Chronic obstructive pulmonary disease	CA22	Phase 2	[14]
SB-265610	DM8TKG5	Asthma	CA23	Phase 2	[15]
AZD-5069	DM3JSFK	Asthma	CA23	Phase 2	[16]
PS-938285	DMHZIFJ	Chronic obstructive pulmonary disease	CA22	Phase 2	[17]
GSK1325756	DMA6RBF	Chronic obstructive pulmonary disease	CA22	Phase 2	[18]
SB-656933	DMCY785	Chronic obstructive pulmonary disease	CA22	Phase 2	[11]
RIST4721	DMA3DKO	Hidradenitis suppurativa	ED92.0	Phase 2	[19]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[20]
Haloperidol	DM96SE0	Delirium		Approved	[21]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[22]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[23]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[24]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[25]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[26]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[27]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[28]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[29]

Drug(s) Targeting Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[30]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[30]
[Pterin-6-Yl Methanyl]-Phosphonophosphate	DM4ZY79	Discovery agent	N.A.	Investigative	[30]
6-Hydroxymethyl-7,8-Dihydropterin	DMYF60K	Discovery agent	N.A.	Investigative	[30]
6-Hydroxymethylpterin	DM7EWDN	Discovery agent	N.A.	Investigative	[31]
P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate	DMOY627	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK)	TT38ECI	HPPK_ECOLI	Inhibitor	[2]
C-X-C chemokine receptor type 2 (CXCR2)	TT30C9G	CXCR2_HUMAN	Antagonist	[3]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[1]
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Antagonist	[1]

References

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