| DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
| Ivosidenib |
DM8S6T7
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ivosidenib. |
Acute myeloid leukaemia [2A60]
|
[26] |
| Midostaurin |
DMI6E0R
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Midostaurin. |
Acute myeloid leukaemia [2A60]
|
[22] |
| Idarubicin |
DMM0XGL
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Idarubicin. |
Acute myeloid leukaemia [2A60]
|
[22] |
| Daunorubicin |
DMQUSBT
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Daunorubicin. |
Acute myeloid leukaemia [2A60]
|
[22] |
| Oliceridine |
DM6MDCF
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Oliceridine. |
Acute pain [MG31]
|
[27] |
| Scopolamine |
DMOM8AL
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Scopolamine. |
Addictive disorder [6C50-6C5Z]
|
[24] |
| Mitotane |
DMU1GX0
|
Major |
Increased metabolism of Haloperidol caused by Mitotane mediated induction of CYP450 enzyme. |
Adrenal cancer [2D11]
|
[28] |
| Mepyramine |
DMB4SFH
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Mepyramine. |
Allergic/hypersensitivity disorder [4A80-4A8Z]
|
[29] |
| Phenyltoloxamine |
DMKAEQW
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Phenyltoloxamine. |
Allergic/hypersensitivity disorder [4A80-4A8Z]
|
[29] |
| Memantine |
DMD9WSC
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Memantine. |
Alzheimer disease [8A20]
|
[24] |
| Rivastigmine |
DMG629M
|
Moderate |
Antagonize the effect of Haloperidol when combined with Rivastigmine. |
Alzheimer disease [8A20]
|
[30] |
| Donepezil |
DMIYG7Z
|
Moderate |
Antagonize the effect of Haloperidol when combined with Donepezil. |
Alzheimer disease [8A20]
|
[30] |
| Metronidazole |
DMTIVEN
|
Minor |
Increased risk of prolong QT interval by the combination of Haloperidol and Metronidazole. |
Amoebiasis [1A36]
|
[31] |
| Isosorbide dinitrate |
DMBI4JG
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Isosorbide dinitrate. |
Anal fissure/fistula [DB50]
|
[32] |
| Trimethaphan |
DMHF4IQ
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Trimethaphan. |
Aneurysm/dissection [BD50]
|
[33] |
| Ivabradine |
DM0L594
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Ivabradine. |
Angina pectoris [BA40]
|
[25] |
| Dronedarone |
DMA8FS5
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Dronedarone. |
Angina pectoris [BA40]
|
[22] |
| Amyl nitrite |
DMJKO05
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Amyl nitrite. |
Angina pectoris [BA40]
|
[32] |
| Nifedipine |
DMSVOZT
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Nifedipine. |
Angina pectoris [BA40]
|
[32] |
| Bedaquiline |
DM3906J
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Bedaquiline. |
Antimicrobial drug resistance [MG50-MG52]
|
[22] |
| Hydroxyzine |
DMF8Y74
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Hydroxyzine. |
Anxiety disorder [6B00-6B0Z]
|
[22] |
| Cilostazol |
DMZMSCT
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Cilostazol. |
Arterial occlusive disease [BD40]
|
[22] |
| Voriconazole |
DMAOL2S
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Voriconazole. |
Aspergillosis [1F20]
|
[22] |
| Posaconazole |
DMUL5EW
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Posaconazole. |
Aspergillosis [1F20]
|
[22] |
| Levalbuterol |
DM5YBO1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Levalbuterol. |
Asthma [CA23]
|
[34] |
| Terbutaline |
DMD4381
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Terbutaline. |
Asthma [CA23]
|
[35] |
| Pirbuterol |
DMI5678
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Pirbuterol. |
Asthma [CA23]
|
[35] |
| Salbutamol |
DMN9CWF
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Salbutamol. |
Asthma [CA23]
|
[36] |
| Lisdexamfetamine |
DM6W8V5
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lisdexamfetamine. |
Attention deficit hyperactivity disorder [6A05]
|
[22] |
| Desipramine |
DMT2FDC
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Desipramine. |
Attention deficit hyperactivity disorder [6A05]
|
[37] |
| Ofloxacin |
DM0VQN3
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Ciprofloxacin XR |
DM2NLS9
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ciprofloxacin XR. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Clarithromycin |
DM4M1SG
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Clarithromycin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Sulfamethoxazole |
DMB08GE
|
Minor |
Increased risk of prolong QT interval by the combination of Haloperidol and Sulfamethoxazole. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Sparfloxacin |
DMB4HCT
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Sparfloxacin. |
Bacterial infection [1A00-1C4Z]
|
[38] |
| Gemifloxacin |
DMHT34O
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Gemifloxacin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Norfloxacin |
DMIZ6W2
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Norfloxacin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Levofloxacin |
DMS60RB
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Levofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Lomefloxacin |
DMVRH9C
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lomefloxacin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Telithromycin |
DMZ4P3A
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Telithromycin. |
Bacterial infection [1A00-1C4Z]
|
[22] |
| Retigabine |
DMGNYIH
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Retigabine. |
Behcet disease [4A62]
|
[22] |
| Cariprazine |
DMJYDVK
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Cariprazine. |
Bipolar disorder [6A60]
|
[24] |
| Loperamide |
DMOJZQ9
|
Moderate |
Additive antimotility effects by the combination of Haloperidol and Loperamide. |
Bowel habit change [ME05]
|
[39] |
| Eribulin |
DM1DX4Q
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Eribulin. |
Breast cancer [2C60-2C6Y]
|
[22] |
| Lapatinib |
DM3BH1Y
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lapatinib. |
Breast cancer [2C60-2C6Y]
|
[22] |
| Tucatinib |
DMBESUA
|
Moderate |
Decreased metabolism of Haloperidol caused by Tucatinib mediated inhibition of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[40] |
| Toremifene |
DMQYUWG
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Toremifene. |
Breast cancer [2C60-2C6Y]
|
[22] |
| Bosutinib |
DMTI8YE
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Bosutinib. |
Breast cancer [2C60-2C6Y]
|
[22] |
| Acetylcholine |
DMDF79Z
|
Moderate |
Antagonize the effect of Haloperidol when combined with Acetylcholine. |
Cataract [9B10]
|
[41] |
| PF-04449913 |
DMSB068
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and PF-04449913. |
Chronic myelomonocytic leukaemia [2A40]
|
[22] |
| Umeclidinium |
DM4E8O9
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Umeclidinium. |
Chronic obstructive pulmonary disease [CA22]
|
[42] |
| Olodaterol |
DM62B78
|
Moderate |
Increased risk of prolong QT interval by the combination of Haloperidol and Olodaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[35] |
| Vilanterol |
DMF5EK1
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Vilanterol. |
Chronic obstructive pulmonary disease [CA22]
|
[34] |
| Tiotropium |
DMFDC0Q
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Tiotropium. |
Chronic obstructive pulmonary disease [CA22]
|
[42] |
| Salmeterol |
DMIEU69
|
Moderate |
Increased risk of prolong QT interval by the combination of Haloperidol and Salmeterol. |
Chronic obstructive pulmonary disease [CA22]
|
[35] |
| Revefenacin |
DMMP5SI
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Revefenacin. |
Chronic obstructive pulmonary disease [CA22]
|
[42] |
| Indacaterol |
DMQJHR7
|
Moderate |
Increased risk of prolong QT interval by the combination of Haloperidol and Indacaterol. |
Chronic obstructive pulmonary disease [CA22]
|
[35] |
| Arformoterol |
DMYM974
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Arformoterol. |
Chronic obstructive pulmonary disease [CA22]
|
[35] |
| Dihydrocodeine |
DMB0FWL
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Dihydrocodeine. |
Chronic pain [MG30]
|
[43] |
| Oxaliplatin |
DMQNWRD
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Oxaliplatin. |
Colorectal cancer [2B91]
|
[22] |
| Isoproterenol |
DMK7MEY
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Isoproterenol. |
Conduction disorder [BC63]
|
[35] |
| Olopatadine |
DMKMWQG
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Olopatadine. |
Conjunctiva disorder [9A60]
|
[44] |
| Halothane |
DM80OZ5
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Halothane. |
Corneal disease [9A76-9A78]
|
[22] |
| Propofol |
DMB4OLE
|
Moderate |
Increased risk of prolong QT interval by the combination of Haloperidol and Propofol. |
Corneal disease [9A76-9A78]
|
[45] |
| Sevoflurane |
DMC9O43
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Sevoflurane. |
Corneal disease [9A76-9A78]
|
[22] |
| Alfentanil |
DMVO0UB
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Alfentanil. |
Corneal disease [9A76-9A78]
|
[27] |
| Remifentanil |
DMZTXCH
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Remifentanil. |
Corneal disease [9A76-9A78]
|
[27] |
| Probucol |
DMVZQ2M
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Probucol. |
Coronary atherosclerosis [BA80]
|
[22] |
| Dextromethorphan |
DMUDJZM
|
Moderate |
Decreased metabolism of Haloperidol caused by Dextromethorphan mediated inhibition of CYP450 enzyme. |
Cough [MD12]
|
[31] |
| Clofazimine |
DMEBOFW
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Clofazimine. |
Crohn disease [DD70]
|
[22] |
| Mifepristone |
DMGZQEF
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Mifepristone. |
Cushing syndrome [5A70]
|
[22] |
| Pasireotide |
DMHM7JS
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Pasireotide. |
Cushing syndrome [5A70]
|
[22] |
| Osilodrostat |
DMIJC9X
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Osilodrostat. |
Cushing syndrome [5A70]
|
[22] |
| Lumacaftor |
DMCLWDJ
|
Major |
Increased metabolism of Haloperidol caused by Lumacaftor mediated induction of CYP450 enzyme. |
Cystic fibrosis [CA25]
|
[46] |
| Ivacaftor |
DMZC1HS
|
Moderate |
Decreased clearance of Haloperidol due to the transporter inhibition by Ivacaftor. |
Cystic fibrosis [CA25]
|
[47] |
| Ethanol |
DMDRQZU
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Ethanol. |
Cystitis [GC00]
|
[44] |
| MK-8228 |
DMOB58Q
|
Moderate |
Decreased metabolism of Haloperidol caused by MK-8228 mediated inhibition of CYP450 enzyme. |
Cytomegaloviral disease [1D82]
|
[48] |
| Cyclandelate |
DMO0R76
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Cyclandelate. |
Dementia [6D80-6D8Z]
|
[32] |
| Aprepitant |
DM053KT
|
Moderate |
Decreased metabolism of Haloperidol caused by Aprepitant mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[49] |
| Sertraline |
DM0FB1J
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Sertraline. |
Depression [6A70-6A7Z]
|
[22] |
| Trimipramine |
DM1SC8M
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Trimipramine. |
Depression [6A70-6A7Z]
|
[37] |
| Cyclobenzaprine |
DM1YBRM
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Cyclobenzaprine. |
Depression [6A70-6A7Z]
|
[24] |
| Nortriptyline |
DM4KDYJ
|
Major |
Decreased metabolism of Haloperidol caused by Nortriptyline mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[37] |
| Paroxetine |
DM5PVQE
|
Moderate |
Decreased metabolism of Haloperidol caused by Paroxetine mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[50] |
| Escitalopram |
DMFK9HG
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Escitalopram. |
Depression [6A70-6A7Z]
|
[22] |
| OPC-34712 |
DMHG57U
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and OPC-34712. |
Depression [6A70-6A7Z]
|
[24] |
| Clomipramine |
DMINRKW
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Clomipramine. |
Depression [6A70-6A7Z]
|
[37] |
| Trazodone |
DMK1GBJ
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Trazodone. |
Depression [6A70-6A7Z]
|
[22] |
| Amoxapine |
DMKITQE
|
Major |
Decreased metabolism of Haloperidol caused by Amoxapine mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[37] |
| Doxepin |
DMPI98T
|
Major |
Decreased metabolism of Haloperidol caused by Doxepin mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[37] |
| Maprotiline |
DMPWB7T
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Maprotiline. |
Depression [6A70-6A7Z]
|
[22] |
| Nitroglycerin |
DMQ2491
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Nitroglycerin. |
Diabetic foot ulcer [BD54]
|
[32] |
| Mepenzolate |
DM8YU2F
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Mepenzolate. |
Digestive system disease [DE2Z]
|
[24] |
| Oxybutynine |
DMJPBAX
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Oxybutynine. |
Discovery agent [N.A.]
|
[24] |
| Tetrabenazine |
DMYWQ0O
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Tetrabenazine. |
Dissociative neurological symptom disorder [6B60]
|
[51] |
| Meclizine |
DMS7T13
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Meclizine. |
Dizziness and giddiness [MB48]
|
[24] |
| Deutetrabenazine |
DMUPFLI
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Deutetrabenazine. |
Dystonic disorder [8A02]
|
[52] |
| Ingrezza |
DMVPLNC
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ingrezza. |
Dystonic disorder [8A02]
|
[22] |
| Zonisamide |
DM0DTF7
|
Major |
Increased risk of hyperpyrexia by the combination of Haloperidol and Zonisamide. |
Epilepsy/seizure [8A61-8A6Z]
|
[53] |
| Primidone |
DM0WX6I
|
Major |
Increased metabolism of Haloperidol caused by Primidone mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[28] |
| Mephenytoin |
DM5UGDK
|
Moderate |
Antagonize the effect of Haloperidol when combined with Mephenytoin. |
Epilepsy/seizure [8A61-8A6Z]
|
[25] |
| Cenobamate |
DM8KLU9
|
Moderate |
Increased metabolism of Haloperidol caused by Cenobamate mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[54] |
| Fosphenytoin |
DMOX3LB
|
Major |
Increased metabolism of Haloperidol caused by Fosphenytoin mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[28] |
| Rufinamide |
DMWE60C
|
Moderate |
Increased metabolism of Haloperidol caused by Rufinamide mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[25] |
| Ethotoin |
DMXWOCP
|
Moderate |
Antagonize the effect of Haloperidol when combined with Ethotoin. |
Epilepsy/seizure [8A61-8A6Z]
|
[25] |
| Phenobarbital |
DMXZOCG
|
Major |
Increased metabolism of Haloperidol caused by Phenobarbital mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[28] |
| Carbamazepine |
DMZOLBI
|
Major |
Increased metabolism of Haloperidol caused by Carbamazepine mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[28] |
| Diphenhydramine |
DMKQTBA
|
Moderate |
Antagonize the effect of Haloperidol when combined with Diphenhydramine. |
Episodic vestibular syndrome [AB31]
|
[55] |
| Guanabenz |
DM5QWEL
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Guanabenz. |
Essential hypertension [BA00]
|
[32] |
| Ethacrynic acid |
DM60QMR
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Ethacrynic acid. |
Essential hypertension [BA00]
|
[33] |
| Phenoxybenzamine |
DM8KSQH
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Phenoxybenzamine. |
Essential hypertension [BA00]
|
[32] |
| Nicardipine |
DMCDYW7
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Nicardipine. |
Essential hypertension [BA00]
|
[32] |
| Mecamylamine |
DMGQFYB
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Mecamylamine. |
Essential hypertension [BA00]
|
[32] |
| Benzthiazide |
DMQWZ0H
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Benzthiazide. |
Essential hypertension [BA00]
|
[31] |
| Nadolol |
DMW6GVL
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Nadolol. |
Essential hypertension [BA00]
|
[32] |
| Tazemetostat |
DMWP1BH
|
Moderate |
Increased metabolism of Haloperidol caused by Tazemetostat mediated induction of CYP450 enzyme. |
Follicular lymphoma [2A80]
|
[56] |
| Solifenacin |
DMG592Q
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Solifenacin. |
Functional bladder disorder [GC50]
|
[22] |
| Mirabegron |
DMS1GYT
|
Moderate |
Decreased metabolism of Haloperidol caused by Mirabegron mediated inhibition of CYP450 enzyme. |
Functional bladder disorder [GC50]
|
[57] |
| Tolterodine |
DMSHPW8
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Tolterodine. |
Functional bladder disorder [GC50]
|
[24] |
| Itraconazole |
DMCR1MV
|
Moderate |
Decreased metabolism of Haloperidol caused by Itraconazole mediated inhibition of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[58] |
| Pentamidine |
DMHZJCG
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Pentamidine. |
Fungal infection [1F29-1F2F]
|
[22] |
| Terbinafine |
DMI6HUW
|
Moderate |
Decreased metabolism of Haloperidol caused by Terbinafine mediated inhibition of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[59] |
| Ketoconazole |
DMPZI3Q
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ketoconazole. |
Fungal infection [1F29-1F2F]
|
[22] |
| Amphotericin B |
DMTAJQE
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Amphotericin B. |
Fungal infection [1F29-1F2F]
|
[31] |
| Phentolamine |
DMXYJOB
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Phentolamine. |
Gangrene [MC85]
|
[32] |
| Propantheline |
DM2EN6G
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Propantheline. |
Gastric ulcer [DA60]
|
[24] |
| Cisapride |
DMY7PED
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Cisapride. |
Gastro-oesophageal reflux disease [DA22]
|
[22] |
| Sunitinib |
DMCBJSR
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Sunitinib. |
Gastrointestinal stromal tumour [2B5B]
|
[22] |
| Acetazolamide |
DM1AF5U
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Acetazolamide. |
Glaucoma [9C61]
|
[31] |
| Isoflurophate |
DMBSK7X
|
Moderate |
Antagonize the effect of Haloperidol when combined with Isoflurophate. |
Glaucoma [9C61]
|
[41] |
| Carteolol |
DMFMDOB
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Carteolol. |
Glaucoma [9C61]
|
[32] |
| Pilocarpine |
DMV9ADG
|
Moderate |
Antagonize the effect of Haloperidol when combined with Pilocarpine. |
Glaucoma [9C61]
|
[41] |
| Eplerenone |
DMF0NQR
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Eplerenone. |
Heart failure [BD10-BD1Z]
|
[32] |
| Carvedilol |
DMHTEAO
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Carvedilol. |
Heart failure [BD10-BD1Z]
|
[32] |
| Chlorothiazide |
DMLHESP
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Chlorothiazide. |
Heart failure [BD10-BD1Z]
|
[31] |
| Furosemide |
DMMQ8ZG
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Furosemide. |
Heart failure [BD10-BD1Z]
|
[31] |
| Amiloride |
DMRTSGP
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Amiloride. |
Heart failure [BD10-BD1Z]
|
[32] |
| Bumetanide |
DMRV7H0
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Bumetanide. |
Heart failure [BD10-BD1Z]
|
[31] |
| Hydroflumethiazide |
DMVPUQI
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Hydroflumethiazide. |
Heart failure [BD10-BD1Z]
|
[31] |
| Isoniazid |
DM5JVS3
|
Minor |
Decreased metabolism of Haloperidol caused by Isoniazid. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[60] |
| Rifampin |
DMA8J1G
|
Major |
Increased metabolism of Haloperidol caused by Rifampin mediated induction of CYP450 enzyme. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[46] |
| Rifapentine |
DMCHV4I
|
Major |
Increased metabolism of Haloperidol caused by Rifapentine mediated induction of CYP450 enzyme. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[28] |
| Fostemsavir |
DM50ILT
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Fostemsavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[22] |
| Cobicistat |
DM6L4H2
|
Moderate |
Decreased clearance of Haloperidol due to the transporter inhibition by Cobicistat. |
Human immunodeficiency virus disease [1C60-1C62]
|
[61] |
| Efavirenz |
DMC0GSJ
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Efavirenz. |
Human immunodeficiency virus disease [1C60-1C62]
|
[62] |
| Saquinavir |
DMG814N
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Saquinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[63] |
| Etravirine |
DMGV8QU
|
Moderate |
Increased metabolism of Haloperidol caused by Etravirine mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[64] |
| Lopinavir |
DMITQS0
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lopinavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[22] |
| Rilpivirine |
DMJ0QOW
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Rilpivirine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[22] |
| Darunavir |
DMN3GCH
|
Moderate |
Decreased metabolism of Haloperidol caused by Darunavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[65] |
| Ritonavir |
DMU764S
|
Moderate |
Decreased metabolism of Haloperidol caused by Ritonavir mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[66] |
| Isosorbide mononitrate |
DMYLMU0
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Isosorbide mononitrate. |
Hydrocephalus [8D64]
|
[32] |
| Cinacalcet |
DMCX0K3
|
Moderate |
Decreased metabolism of Haloperidol caused by Cinacalcet mediated inhibition of CYP450 enzyme. |
Hyper-parathyroidism [5A51]
|
[31] |
| Eprosartan |
DM07K2I
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Eprosartan. |
Hypertension [BA00-BA04]
|
[32] |
| Acebutolol |
DM0TI4U
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Acebutolol. |
Hypertension [BA00-BA04]
|
[32] |
| Moexipril |
DM26E4B
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Moexipril. |
Hypertension [BA00-BA04]
|
[32] |
| Bisoprolol |
DM3UZ95
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Bisoprolol. |
Hypertension [BA00-BA04]
|
[32] |
| Captopril |
DM458UM
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Captopril. |
Hypertension [BA00-BA04]
|
[32] |
| Penbutolol |
DM4ES8F
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Penbutolol. |
Hypertension [BA00-BA04]
|
[32] |
| Clonidine |
DM6RZ9Q
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Clonidine. |
Hypertension [BA00-BA04]
|
[32] |
| Losartan |
DM72JXH
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Losartan. |
Hypertension [BA00-BA04]
|
[32] |
| Nebivolol |
DM7F1PA
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Nebivolol. |
Hypertension [BA00-BA04]
|
[32] |
| Verapamil |
DMA7PEW
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Verapamil. |
Hypertension [BA00-BA04]
|
[32] |
| Pindolol |
DMD2NV7
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Pindolol. |
Hypertension [BA00-BA04]
|
[32] |
| Fenoldopam |
DMFAOKP
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Fenoldopam. |
Hypertension [BA00-BA04]
|
[32] |
| Indapamide |
DMGN1PW
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Indapamide. |
Hypertension [BA00-BA04]
|
[31] |
| Benazepril |
DMH1M9B
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Benazepril. |
Hypertension [BA00-BA04]
|
[32] |
| Trichlormethiazide |
DMHAQCO
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Trichlormethiazide. |
Hypertension [BA00-BA04]
|
[32] |
| Labetalol |
DMK8U72
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Labetalol. |
Hypertension [BA00-BA04]
|
[32] |
| Diazoxide |
DML1538
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Diazoxide. |
Hypertension [BA00-BA04]
|
[32] |
| Enalapril |
DMNFUZR
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Enalapril. |
Hypertension [BA00-BA04]
|
[32] |
| Perindopril |
DMOPZDT
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Perindopril. |
Hypertension [BA00-BA04]
|
[32] |
| Quinapril |
DMR8H31
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Quinapril. |
Hypertension [BA00-BA04]
|
[32] |
| Deserpidine |
DMRH7CV
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Deserpidine. |
Hypertension [BA00-BA04]
|
[32] |
| Telmisartan |
DMS3GX2
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Telmisartan. |
Hypertension [BA00-BA04]
|
[32] |
| Irbesartan |
DMTP1DC
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Irbesartan. |
Hypertension [BA00-BA04]
|
[32] |
| Hydralazine |
DMU8JGH
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Hydralazine. |
Hypertension [BA00-BA04]
|
[32] |
| Lisinopril |
DMUOK4C
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Lisinopril. |
Hypertension [BA00-BA04]
|
[32] |
| Hydrochlorothiazide |
DMUSZHD
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Hydrochlorothiazide. |
Hypertension [BA00-BA04]
|
[31] |
| Clevidipine butyrate |
DMW4M97
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Clevidipine butyrate. |
Hypertension [BA00-BA04]
|
[32] |
| Conivaptan |
DM1V329
|
Moderate |
Decreased metabolism of Haloperidol caused by Conivaptan mediated inhibition of CYP450 enzyme. |
Hypo-osmolality/hyponatraemia [5C72]
|
[67] |
| Givosiran |
DM5PFIJ
|
Moderate |
Decreased metabolism of Haloperidol caused by Givosiran mediated inhibition of CYP450 enzyme. |
Inborn porphyrin/heme metabolism error [5C58]
|
[68] |
| Belladonna |
DM2RBWK
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Belladonna. |
Infectious gastroenteritis/colitis [1A40]
|
[24] |
| Amantadine |
DMS3YE9
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Amantadine. |
Influenza [1E30-1E32]
|
[69] |
| Berotralstat |
DMWA2DZ
|
Moderate |
Decreased metabolism of Haloperidol caused by Berotralstat mediated inhibition of CYP450 enzyme. |
Innate/adaptive immunodeficiency [4A00]
|
[70] |
| Propiomazine |
DMKY8V1
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Propiomazine. |
Insomnia [7A00-7A0Z]
|
[24] |
| ITI-007 |
DMUQ1DO
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and ITI-007. |
Insomnia [7A00-7A0Z]
|
[24] |
| Polyethylene glycol |
DM4I1JP
|
Moderate |
Increased risk of lowers seizure threshold by the combination of Haloperidol and Polyethylene glycol. |
Irritable bowel syndrome [DD91]
|
[22] |
| Phenolphthalein |
DM5SICT
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Phenolphthalein. |
Irritable bowel syndrome [DD91]
|
[22] |
| Clidinium |
DMUMQZ0
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Clidinium. |
Irritable bowel syndrome [DD91]
|
[24] |
| Dicyclomine |
DMZSDGX
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Dicyclomine. |
Irritable bowel syndrome [DD91]
|
[24] |
| Physostigmine |
DM2N0TO
|
Moderate |
Antagonize the effect of Haloperidol when combined with Physostigmine. |
Lips/oral mucosa miscellaneous disorder [DA02]
|
[30] |
| Crizotinib |
DM4F29C
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Crizotinib. |
Lung cancer [2C25]
|
[22] |
| Brigatinib |
DM7W94S
|
Moderate |
Increased metabolism of Haloperidol caused by Brigatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[71] |
| Porfimer Sodium |
DM7ZWNY
|
Moderate |
Increased risk of photosensitivity reactions by the combination of Haloperidol and Porfimer Sodium. |
Lung cancer [2C25]
|
[72] |
| Ceritinib |
DMB920Z
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ceritinib. |
Lung cancer [2C25]
|
[22] |
| PF-06463922 |
DMKM7EW
|
Moderate |
Increased metabolism of Haloperidol caused by PF-06463922 mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[73] |
| Dacomitinib |
DMOH8VY
|
Moderate |
Decreased metabolism of Haloperidol caused by Dacomitinib mediated inhibition of CYP450 enzyme. |
Lung cancer [2C25]
|
[74] |
| Osimertinib |
DMRJLAT
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Osimertinib. |
Lung cancer [2C25]
|
[22] |
| Selpercatinib |
DMZR15V
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Selpercatinib. |
Lung cancer [2C25]
|
[22] |
| Lumefantrine |
DM29GAD
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lumefantrine. |
Malaria [1F40-1F45]
|
[31] |
| Halofantrine |
DMOMK1V
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Halofantrine. |
Malaria [1F40-1F45]
|
[75] |
| Chloroquine |
DMSI5CB
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Chloroquine. |
Malaria [1F40-1F45]
|
[22] |
| Hydroxychloroquine |
DMSIVND
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Hydroxychloroquine. |
Malaria [1F40-1F45]
|
[22] |
| Primaquine |
DMWQ16I
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Primaquine. |
Malaria [1F40-1F45]
|
[22] |
| Inotuzumab ozogamicin |
DMAC130
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Inotuzumab ozogamicin. |
Malignant haematopoietic neoplasm [2B33]
|
[22] |
| Idelalisib |
DM602WT
|
Moderate |
Decreased metabolism of Haloperidol caused by Idelalisib mediated inhibition of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[76] |
| IPI-145 |
DMWA24P
|
Moderate |
Decreased metabolism of Haloperidol caused by IPI-145 mediated inhibition of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[77] |
| Arsenic trioxide |
DM61TA4
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Arsenic trioxide. |
Mature B-cell lymphoma [2A85]
|
[78] |
| Vemurafenib |
DM62UG5
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Vemurafenib. |
Melanoma [2C30]
|
[22] |
| LGX818 |
DMNQXV8
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and LGX818. |
Melanoma [2C30]
|
[22] |
| Dabrafenib |
DMX6OE3
|
Moderate |
Increased metabolism of Haloperidol caused by Dabrafenib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[25] |
| Allopregnanolone |
DMNLHAC
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Allopregnanolone. |
Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]
|
[79] |
| Lasmiditan |
DMXLVDT
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Lasmiditan. |
Migraine [8A80]
|
[80] |
| Exjade |
DMHPRWG
|
Moderate |
Decreased metabolism of Haloperidol caused by Exjade mediated inhibition of CYP450 enzyme. |
Mineral absorption/transport disorder [5C64]
|
[81] |
| Flibanserin |
DM70DTN
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Flibanserin. |
Mood disorder [6A60-6E23]
|
[82] |
| Panobinostat |
DM58WKG
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Panobinostat. |
Multiple myeloma [2A83]
|
[83] |
| Thalidomide |
DM70BU5
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Thalidomide. |
Multiple myeloma [2A83]
|
[84] |
| Siponimod |
DM2R86O
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Siponimod. |
Multiple sclerosis [8A40]
|
[31] |
| Fingolimod |
DM5JVAN
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Fingolimod. |
Multiple sclerosis [8A40]
|
[22] |
| Ozanimod |
DMT6AM2
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Ozanimod. |
Multiple sclerosis [8A40]
|
[85] |
| Rifabutin |
DM1YBHK
|
Major |
Increased metabolism of Haloperidol caused by Rifabutin mediated induction of CYP450 enzyme. |
Mycobacterium infection [1B10-1B21]
|
[28] |
| Romidepsin |
DMT5GNL
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Romidepsin. |
Mycosis fungoides [2B01]
|
[22] |
| Fedratinib |
DM4ZBK6
|
Moderate |
Decreased metabolism of Haloperidol caused by Fedratinib mediated inhibition of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[25] |
| Nilotinib |
DM7HXWT
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Nilotinib. |
Myeloproliferative neoplasm [2A20]
|
[22] |
| Imatinib |
DM7RJXL
|
Moderate |
Decreased metabolism of Haloperidol caused by Imatinib mediated inhibition of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[86] |
| Dasatinib |
DMJV2EK
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Dasatinib. |
Myeloproliferative neoplasm [2A20]
|
[22] |
| Dextroamphetamine |
DMMIHVP
|
Moderate |
Antagonize the effect of Haloperidol when combined with Dextroamphetamine. |
Narcolepsy [7A20]
|
[87] |
| Modafinil |
DMYILBE
|
Minor |
Increased metabolism of Haloperidol caused by Modafinil mediated induction of CYP450 enzyme. |
Narcolepsy [7A20]
|
[88] |
| Phenindamine |
DMDTC7R
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Phenindamine. |
Nasopharyngitis [CA00]
|
[24] |
| Dimenhydrinate |
DM264B3
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Dimenhydrinate. |
Nausea/vomiting [MD90]
|
[24] |
| Promethazine |
DM6I5GR
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Promethazine. |
Nausea/vomiting [MD90]
|
[22] |
| Rolapitant |
DM8XP26
|
Moderate |
Decreased metabolism of Haloperidol caused by Rolapitant mediated inhibition of CYP450 enzyme. |
Nausea/vomiting [MD90]
|
[89] |
| Cyclizine |
DM9G7BS
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Cyclizine. |
Nausea/vomiting [MD90]
|
[24] |
| Metoclopramide |
DMFA5MY
|
Major |
Additive antidopaminergic effects by the combination of Haloperidol and Metoclopramide. |
Nausea/vomiting [MD90]
|
[90] |
| Granisetron |
DMIUW25
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Granisetron. |
Nausea/vomiting [MD90]
|
[22] |
| Dolasetron |
DMMG26Z
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Dolasetron. |
Nausea/vomiting [MD90]
|
[22] |
| Ondansetron |
DMOTQ1I
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Ondansetron. |
Nausea/vomiting [MD90]
|
[22] |
| Bupropion |
DM5PCS7
|
Major |
Decreased metabolism of Haloperidol caused by Bupropion mediated inhibition of CYP450 enzyme. |
Nicotine use disorder [6C4A]
|
[22] |
| Entrectinib |
DMMPTLH
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[22] |
| Phendimetrazine |
DM6TS1N
|
Moderate |
Antagonize the effect of Haloperidol when combined with Phendimetrazine. |
Obesity [5B80-5B81]
|
[87] |
| Amfepramone |
DM9YSNQ
|
Moderate |
Antagonize the effect of Haloperidol when combined with Amfepramone. |
Obesity [5B80-5B81]
|
[87] |
| Lorcaserin |
DMG6OYJ
|
Moderate |
Decreased metabolism of Haloperidol caused by Lorcaserin mediated inhibition of CYP450 enzyme. |
Obesity [5B80-5B81]
|
[91] |
| Benzphetamine |
DMIJATC
|
Moderate |
Antagonize the effect of Haloperidol when combined with Benzphetamine. |
Obesity [5B80-5B81]
|
[87] |
| Mazindol |
DMZ36RN
|
Moderate |
Antagonize the effect of Haloperidol when combined with Mazindol. |
Obesity [5B80-5B81]
|
[87] |
| Metolazone |
DMB39LO
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Metolazone. |
Oedema [MG29]
|
[31] |
| Polythiazide |
DMCH80F
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Polythiazide. |
Oedema [MG29]
|
[31] |
| Levomethadyl Acetate |
DM06HG5
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[25] |
| Lofexidine |
DM1WXA6
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lofexidine. |
Opioid use disorder [6C43]
|
[22] |
| Apraclonidine |
DMO4PVE
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Apraclonidine. |
Optic nerve disorder [9C40]
|
[92] |
| Rucaparib |
DM9PVX8
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Rucaparib. |
Ovarian cancer [2C73]
|
[22] |
| Pentazocine |
DM1XBHS
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Pentazocine. |
Pain [MG30-MG3Z]
|
[27] |
| Dextropropoxyphene |
DM23HCX
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Dextropropoxyphene. |
Pain [MG30-MG3Z]
|
[93] |
| Butorphanol |
DM5KYPJ
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Butorphanol. |
Pain [MG30-MG3Z]
|
[27] |
| Oxymorphone |
DM65AGJ
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Oxymorphone. |
Pain [MG30-MG3Z]
|
[27] |
| Levorphanol |
DMGS80V
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Levorphanol. |
Pain [MG30-MG3Z]
|
[27] |
| Dezocine |
DMJDB0Y
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Dezocine. |
Pain [MG30-MG3Z]
|
[27] |
| Flavoxate |
DMKV4NL
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Flavoxate. |
Pain [MG30-MG3Z]
|
[24] |
| Nalbuphine |
DMOSQGU
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Nalbuphine. |
Pain [MG30-MG3Z]
|
[27] |
| Methamphetamine |
DMPM4SK
|
Moderate |
Antagonize the effect of Haloperidol when combined with Methamphetamine. |
Pain [MG30-MG3Z]
|
[94] |
| Buprenorphine |
DMPRI8G
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Buprenorphine. |
Pain [MG30-MG3Z]
|
[22] |
| Hydrocodone |
DMQ2JO5
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Hydrocodone. |
Pain [MG30-MG3Z]
|
[27] |
| Triclabendazole |
DMPWGBR
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Triclabendazole. |
Parasitic worm infestation [1F90]
|
[22] |
| Pergolide |
DM14MAE
|
Moderate |
Antagonize the effect of Haloperidol when combined with Pergolide. |
Parkinsonism [8A00]
|
[95] |
| Opicapone |
DM1BKA6
|
Moderate |
Antagonize the effect of Haloperidol when combined with Opicapone. |
Parkinsonism [8A00]
|
[95] |
| Biperiden |
DME78OA
|
Moderate |
Antagonize the effect of Haloperidol when combined with Biperiden. |
Parkinsonism [8A00]
|
[55] |
| Levodopa |
DMN3E57
|
Moderate |
Antagonize the effect of Haloperidol when combined with Levodopa. |
Parkinsonism [8A00]
|
[95] |
| Pimavanserin |
DMR7IVC
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Pimavanserin. |
Parkinsonism [8A00]
|
[22] |
| Bromocriptine |
DMVE3TK
|
Moderate |
Antagonize the effect of Haloperidol when combined with Bromocriptine. |
Parkinsonism [8A00]
|
[95] |
| Orphenadrine |
DMW542E
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Orphenadrine. |
Parkinsonism [8A00]
|
[24] |
| Apomorphine |
DMX38HQ
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Apomorphine. |
Parkinsonism [8A00]
|
[22] |
| Abametapir |
DM2RX0I
|
Moderate |
Decreased metabolism of Haloperidol caused by Abametapir mediated inhibition of CYP450 enzyme. |
Pediculosis [1G00]
|
[96] |
| Methylscopolamine |
DM5VWOB
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Methylscopolamine. |
Peptic ulcer [DA61]
|
[24] |
| Famotidine |
DMRL3AB
|
Moderate |
Increased risk of prolong QT interval by the combination of Haloperidol and Famotidine. |
Peptic ulcer [DA61]
|
[31] |
| Macimorelin |
DMQYJIR
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Macimorelin. |
Pituitary gland disorder [5A60-5A61]
|
[97] |
| Lefamulin |
DME6G97
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lefamulin. |
Pneumonia [CA40]
|
[98] |
| Hydrocortisone |
DMGEMB7
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Hydrocortisone. |
Postoperative inflammation [1A00-CA43]
|
[31] |
| Lonafarnib |
DMGM2Z6
|
Moderate |
Decreased metabolism of Haloperidol caused by Lonafarnib mediated inhibition of CYP450 enzyme. |
Premature ageing appearance [LD2B]
|
[99] |
| Ritodrine |
DM4V6RL
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Ritodrine. |
Preterm labour/delivery [JB00]
|
[35] |
| Degarelix |
DM3O8QY
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Degarelix. |
Prostate cancer [2C82]
|
[22] |
| ABIRATERONE |
DM8V75C
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and ABIRATERONE. |
Prostate cancer [2C82]
|
[22] |
| Nilutamide |
DMFN07X
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Nilutamide. |
Prostate cancer [2C82]
|
[22] |
| Enzalutamide |
DMGL19D
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Enzalutamide. |
Prostate cancer [2C82]
|
[22] |
| Relugolix |
DMK7IWL
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Relugolix. |
Prostate cancer [2C82]
|
[22] |
| Bicalutamide |
DMZMSPF
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Bicalutamide. |
Prostate cancer [2C82]
|
[22] |
| Terazosin |
DM3JCVS
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Terazosin. |
Prostate hyperplasia [GA90]
|
[32] |
| Tamsulosin |
DM5QF9V
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Tamsulosin. |
Prostate hyperplasia [GA90]
|
[32] |
| Silodosin |
DMJSBT6
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Silodosin. |
Prostate hyperplasia [GA90]
|
[32] |
| Levomepromazine |
DMIKFEL
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Levomepromazine. |
Psychotic disorder [6A20-6A25]
|
[22] |
| Fluphenazine |
DMIT8LX
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Fluphenazine. |
Psychotic disorder [6A20-6A25]
|
[22] |
| Triflupromazine |
DMKFQJP
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Triflupromazine. |
Psychotic disorder [6A20-6A25]
|
[22] |
| Tolazoline |
DMI40NL
|
Moderate |
Additive hypotensive effects by the combination of Haloperidol and Tolazoline. |
Pulmonary hypertension [BB01]
|
[32] |
| Temsirolimus |
DMS104F
|
Moderate |
Increased plasma concentrations of Haloperidol and Temsirolimus due to competitive inhibition of the same metabolic pathway. |
Renal cell carcinoma [2C90]
|
[100] |
| Gatifloxacin |
DMSL679
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Gatifloxacin. |
Respiratory infection [CA07-CA4Z]
|
[22] |
| Neupro |
DMHEAB1
|
Moderate |
Additive CNS depression effects by the combination of Haloperidol and Neupro. |
Restless legs syndrome [7A80]
|
[95] |
| Fentanyl |
DM8WAHT
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Fentanyl. |
Sensation disturbance [MB40]
|
[27] |
| Sufentanil |
DMU7YEL
|
Major |
Additive CNS depression effects by the combination of Haloperidol and Sufentanil. |
Sensation disturbance [MB40]
|
[27] |
| Vardenafil |
DMTBGW8
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Vardenafil. |
Sexual dysfunction [HA00-HA01]
|
[22] |
| Voxelotor |
DMCS6M5
|
Moderate |
Decreased metabolism of Haloperidol caused by Voxelotor mediated inhibition of CYP450 enzyme. |
Sickle-cell disorder [3A51]
|
[101] |
| Telotristat ethyl |
DMDIYFZ
|
Moderate |
Increased metabolism of Haloperidol caused by Telotristat ethyl mediated induction of CYP450 enzyme. |
Small intestine developmental anomaly [DA90]
|
[25] |
| Larotrectinib |
DM26CQR
|
Moderate |
Decreased metabolism of Haloperidol caused by Larotrectinib mediated inhibition of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[31] |
| Armodafinil |
DMGB035
|
Minor |
Increased metabolism of Haloperidol caused by Armodafinil mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[88] |
| LEE011 |
DMMX75K
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[22] |
| Cisplatin |
DMRHGI9
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Cisplatin. |
Solid tumour/cancer [2A00-2F9Z]
|
[31] |
| Vandetanib |
DMRICNP
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Vandetanib. |
Solid tumour/cancer [2A00-2F9Z]
|
[22] |
| Triptorelin |
DMTK4LS
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Triptorelin. |
Solid tumour/cancer [2A00-2F9Z]
|
[22] |
| Doxorubicin |
DMVP5YE
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Doxorubicin. |
Solid tumour/cancer [2A00-2F9Z]
|
[22] |
| Pitolisant |
DM8RFNJ
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Pitolisant. |
Somnolence [MG42]
|
[22] |
| Telavancin |
DM58VQX
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Telavancin. |
Staphylococcal/streptococcal disease [1B5Y]
|
[22] |
| Adenosine |
DMM2NSK
|
Major |
Increased risk of ventricular arrhythmias by the combination of Haloperidol and Adenosine. |
Supraventricular tachyarrhythmia [BC81]
|
[102] |
| Fostamatinib |
DM6AUHV
|
Moderate |
Decreased clearance of Haloperidol due to the transporter inhibition by Fostamatinib. |
Thrombocytopenia [3B64]
|
[103] |
| Lenvatinib |
DMB1IU4
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Lenvatinib. |
Thyroid cancer [2D10]
|
[22] |
| Cabozantinib |
DMIYDT4
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Cabozantinib. |
Thyroid cancer [2D10]
|
[22] |
| Papaverine |
DMCA9QP
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Papaverine. |
Tonus and reflex abnormality [MB47]
|
[104] |
| Tizanidine |
DMR2IQ4
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Tizanidine. |
Tonus and reflex abnormality [MB47]
|
[22] |
| Sirolimus |
DMGW1ID
|
Moderate |
Increased plasma concentrations of Haloperidol and Sirolimus due to competitive inhibition of the same metabolic pathway. |
Transplant rejection [NE84]
|
[100] |
| Tacrolimus |
DMZ7XNQ
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Tacrolimus. |
Transplant rejection [NE84]
|
[22] |
| Atropine |
DMEN6X7
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Atropine. |
Unspecific substance harmful effect [NE6Z]
|
[24] |
| Astemizole |
DM2HN6Q
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Astemizole. |
Vasomotor/allergic rhinitis [CA08]
|
[22] |
| Methdilazine |
DMAUHQX
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Methdilazine. |
Vasomotor/allergic rhinitis [CA08]
|
[24] |
| Carbinoxamine |
DMCT31R
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Carbinoxamine. |
Vasomotor/allergic rhinitis [CA08]
|
[24] |
| Trimeprazine |
DMEMV9D
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Trimeprazine. |
Vasomotor/allergic rhinitis [CA08]
|
[22] |
| Brompheniramine |
DMFOVSD
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Brompheniramine. |
Vasomotor/allergic rhinitis [CA08]
|
[24] |
| Acrivastine |
DMTIGA0
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Acrivastine. |
Vasomotor/allergic rhinitis [CA08]
|
[24] |
| Azatadine |
DMZ80SB
|
Moderate |
Additive anticholinergic effects by the combination of Haloperidol and Azatadine. |
Vasomotor/allergic rhinitis [CA08]
|
[24] |
| Procainamide |
DMNMXR8
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Procainamide. |
Ventricular tachyarrhythmia [BC71]
|
[22] |
| Propafenone |
DMPIBJK
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Propafenone. |
Ventricular tachyarrhythmia [BC71]
|
[22] |
| Flecainide |
DMSQDLE
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Flecainide. |
Ventricular tachyarrhythmia [BC71]
|
[22] |
| Amiodarone |
DMUTEX3
|
Major |
Increased risk of prolong QT interval by the combination of Haloperidol and Amiodarone. |
Ventricular tachyarrhythmia [BC71]
|
[22] |
| ----------- |
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