Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDVP3B)

• Drug Name: Pregabalin Drug Info
• Synonyms: Pregabalin CR; Pregabalin (controlled-release, oral); Pregabalin (controlled-release, oral), Pfizer

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Approved	[1]
Epilepsy	8A60-8A68	Approved	[2]
Pain	MG30-MG3Z	Approved	[2]
Postherpetic neuralgia	1E91.5	Approved	[2]
Vulvodynia		Approved	[2]
Chronic pain	MG30	Investigative	[2]
Neuralgia		Investigative	[2]

• Cross-matching ID:
  PubChem CID: 5486971
  ChEBI ID: CHEBI:64356
  CAS Number: CAS 148553-50-8
  TTD Drug ID: DMDVP3B
  VARIDT Drug ID: DR01255
  ACDINA Drug ID: D00553

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[5]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[6]
Lercanidipine	DMPWSEM	Hypertension	BA00-BA04	Approved	[7]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[8]
Mirogabalin	DM5GIWZ	Peripheral neuropathy	8C0Z	Registered	[9]
Imagabalin	DMRLVUD	Generalized anxiety disorder	6B00	Phase 3	[10]
NP-118809	DM8A64W	Pain	MG30-MG3Z	Discontinued in Phase 2	[11]
PD-144550	DM03526	Discovery agent	N.A.	Investigative	[12]
3-Aminomethyl-5-methyl-hexanoic acid	DMTYXH1	Discovery agent	N.A.	Investigative	[12]
(S)-2-amino-3-cyclohexylpropanoic acid	DM1GBX8	Discovery agent	N.A.	Investigative	[13]

Drug(s) Transported By L-type amino acid transporter 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[14]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[15]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[16]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
L-type amino acid transporter 1 (SLC7A5)	DT48T0N	LAT1_HUMAN	Substrate	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5484).
• [2] Pregabalin FDA Label
• [3] Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76.
• [4] Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246.
• [5] Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009;24(1-2):17-24.
• [6] Sulfobutyl ether-alkyl ether mixed cyclodextrin derivatives with enhanced inclusion ability. J Pharm Sci. 2009 Dec;98(12):4769-80.
• [7] Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):981-7.
• [8] A first drug combination for the treatment of arterial hypertension with a calcium channel antagonist (amlodipine besylate) and an angiotensin receptor blocker (valsartan): Exforge. Rev Med Liege. 2007 Nov;62(11):688-94.
• [9] Efficacy and safety of mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec;37(12):3253-61.
• [10] Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology. Brain Res. 2011 Jul 15;1401:1-9.
• [11] Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72.
• [12] Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994).
• [13] Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.
• [14] Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34.
• [15] Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. Sci Rep. 2017 Mar 8;7:43580.
• [16] Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol. 2013 Jun 1;85(11):1672-83.