Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEQSTP)

• Drug Name: Uridine-Diphosphate-N-Acetylglucosamine Drug Info
• Synonyms: UDP-N-acetylglucosamine; UDP-GlcNAc; UDP-N-acetyl-D-glucosamine; URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE; UPPAG; UDP-acetylglucosamine; uridine diphosphate N-acetylglucosamine; UDP-N-acetyl-alpha-D-glucosamine; Uridine diphosphate-N-acetylglucosamine; 528-04-1; UDP-acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; Uridine 5'-diphospho-N-acetylglucosamine; [(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxy

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 445675
  ChEBI ID: CHEBI:16264
  CAS Number: CAS 528-04-1
  TTD Drug ID: DMEQSTP

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosfomycin	DMVGPMX	Bacterial infection	1A00-1C4Z	Approved	[3]
RWJ-3981	DMBVLCQ	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
RWJ-140998	DMP7SI9	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
Aminomethylcyclohexane	DMNX9FC	Discovery agent	N.A.	Investigative	[5]
EUPATORIOPICRIN	DM068CY	Discovery agent	N.A.	Investigative	[6]
CNICIN	DMEVM0J	Discovery agent	N.A.	Investigative	[6]
L-Iso-Aspartate	DM26AB4	Discovery agent	N.A.	Investigative	[5]
Cyclohexylammonium Ion	DMYQH2N	Discovery agent	N.A.	Investigative	[5]
CYNAROPICRIN	DMG0PHU	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[5]
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[7]
UDP-glucose	DMLT4JA	Discovery agent	N.A.	Investigative	[5]
Uridine Diphosphate Galactose	DMPA0BJ	Discovery agent	N.A.	Investigative	[8]
Uridine-Diphosphate-N-Acetylgalactosamine	DMXHO6J	N. A.	N. A.	Investigative	[5]
Tetramethylammonium Ion	DMLEPYN	Discovery agent	N.A.	Investigative	[5]
Uridine-5'-Diphosphate	DMDQKJB	Discovery agent	N.A.	Investigative	[5]
Phenyl-Uridine-5'-Diphosphate	DM7J0YG	Discovery agent	N.A.	Investigative	[5]
Uridine-5'-Diphosphate-Mannose	DMAYCQU	Discovery agent	N.A.	Investigative	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)	TTICX3S	MURA_ECOLI	Inhibitor	[2]
UDP-glucose 4-epimerase (GALE)	TTGRHIB	GALE_HUMAN	Inhibitor	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1779).
• [2] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [3] Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63.
• [4] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [6] Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.
• [7] Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7.
• [8] Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502.